Chen Sheng, M.D.

Department:Neurosurgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Professor, Associate Chief Physician


Appointment

Clinical / Research Interests

Cerebrovascular diseases, brain tumors (glioma, pituitary tumor, meningioma, schwannoma, et al), traumatic brain injury.

Professional Highlights

Professional Award for Science and Technology Innovation of Zhejiang Province, First Prize

Professional Appointments

Adjunct Associate Professor, Loma Linda University, USA, 2019-present

Editor Board of Peer-Review, Translational Stroke Research, Neuroscience Bulletin

Education Experience

Research Summary

Cerebrovascular diseases (intracranial aneurysms and vascular malformation, et al) and surgery, especially aneurysmal subarchnoid hemorrhage.

Microscopic and neuroendoscopic operation for brain tumor (glioma, meningoma, pituitary tumor and acoustic sehwmanoma).

Comprehensive therapy for brain trauma.

Publications

Fang YJ, Mei SH, Lu JN, Chen YK, Chai ZH, Dong X, Araujo C, Reis C, Zhang JM, Chen S*. New risk score of the early period after spontaneous subarachnoid hemorrhage: For the prediction of delayed cerebral ischemia. CNS Neurosci Ther. 2019;25(10):1173-1181. 

Luo Y#, Lu J, Ruan W, Guo X, Chen S*. MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats. Brain Res Bull. 2019 Feb 1;146:320-326. 

Fang Y, Shao Y, Lu J, Dong X, Zhao X, Zhang J, Chen S*. The effectiveness of lumbar cerebrospinal fluid drainage in aneurysmal subarachnoid hemorrhage with different bleeding amounts. Neurosurg Rev. 2019 Jun 3. 

Shi L#, Al-Baadani A#, Zhou K, Shao A, Xu S, Chen S*, Zhang J*. PCMT1 Ameliorates Neuronal Apoptosis by Inhibiting the Activation of MST1 after Subarachnoid Hemorrhage in Rats. Transl Stroke Res. 2018; 8(5): 474–483.    Chen S#, Mei S#, Luo Y, Wu H, Zhang J, Zhu J*. Gasdermin Family: a Promising Therapeutic Target for Stroke. Transl Stroke Res. 2018 Dec;9(6):555-563. 

Zhou K#, Shi L, Wang Z, Zhou J, Manaenko A, Reis C, Chen S*, Zhang J*. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017;295:116-124.

Chen S*, Feng H#, Sherchan P, Klebe D, Zhao G, Sun X, Zhang J, Tang J, Zhang JH. Controversies and Evolving New Mechanisms in Subarachnoid Hemorrhage. Prog Neurobiol. 2014;115:64-91. 

Ma Q*, Chen S*, Hu Q, Feng H, Zhang JH, Tang J. NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol. 2014;75:209-19.6. 

Chen S*, Ma Q, Krafft PR, Tang JP, Zhang JM, Zhang JH*. P2X7 Receptor Antagonism Inhibits p38 Mitogen-Activated Protein Kinase Activation and Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. Crit Care Med.2013;41(12):e466-74. 

Chen S*, Ma Q, Krafft PR, Hu Q, Rolland W, Sherchan P, Zhang JM*, Tang J*, Zhang J. P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis. 2013;58C:296-307. 

Current Program

The role of NLRP3-mediated pyrotosis in microglia in subarachnoid hemorrhage and LncRNA H19 related regulatory mechanism. Funding Source: National Natural Science Foundation of China

The mechanism and treatment in hemorrhagic stroke. Funding Source: Zhejiang university School of Medicine.

The study of RIP1/RIP3/Drp1 pathway regulate NLRP3 inflammasome activation following subarachnoid hemorrhage. Funding Source: National Natural Science Foundation of China.

The study of PCMT1/MST1pathway in the regulation of neuron apoptosis following subarachnoid hemorrhage.Funding Source: National Natural Science Foundation of China.

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