Wang Changjun, M.D.,Ph.D.

DepartmentOphthalmology

Medical SchoolZhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

General Ophthalmology, especially ocular surface disease, thyroid associated ophthalmopathy, eyelid disease and lacrimal duct disease.

Professional Highlights

Zhejiang Science and Technology Award, Second Prize

Professional Appointments

Member, Chinese Society of Ophthalmology, Chinese Medical Association

Education Experience

Research Summary

To clarify the pathogenesis and to provide new treatments for thyroid associated ophthalmopathy and dry eye diesease.

Publications

Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019,60(13):4224-4233.

Ning Q, Cao J, Xie J, Gao Q, Wang C, Ye J. Unilateral Levator Aponeurosis Excision for Marcus Gunn Syndrome and Risk Factors of Residual Jaw Winking. J Ophthalmol. 2019,2058047.

Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, Wang C, de Souza RG, Lu F, Pflugfelder SC, Li DQ. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019,12(5):1141-1149.

Wang C, Jin K, He J, Wang J, Yang X, Yao C, Dai X, Gao C, Gou Z, Ye J. Synergistic Effect of Copper-Containing Mesoporous Bioactive Glass Coating on Stimulating Vascularization of Porous Hydroxyapatite Orbital Implants in Rabbits. J Biomed Nanotechnol. 2018,14(4):688-697.

Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sj?gren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018,19(2). pii: E565.

Wang C, Ning Q, Jin K, Xie J, Ye J. Does rituximab improve clinical outcomes of patients with thyroid-associated ophthalmopathy? A systematic review and meta-analysis. BMC Ophthalmol. 2018,18(1):46.

Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS. Protective role of commensal bacteria in Sj?gren Syndrome. J Autoimmun. 2018,93:45-56. 

Xie J, Wang C, Ning Q, Gao Q, Gao C, Gou Z, Ye J. A new strategy to sustained release of ocular drugs by one-step drug-loaded microcapsule manufacturing in hydrogel punctal plugs. Graefes Arch Clin Exp Ophthalmol. 2017,255(11):2173-2184.

Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016,231(11):2506-16.

Bian F, Shin CS, Wang C, Pflugfelder SC, Acharya G, De Paiva CS. Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016,57(7):3222-30.

Current Program

Smad1 regulates the differentiation of Th9 cells and its mechanism of immune inflammation modulation on ocular surface in dry eye. Funding Source: Natural Science Foundation of Zhejiang.

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