Medical School：Shandong University, School of Medicine, China
Academic Rank：Associate Chief Physician
Comprehensive treatment and minimally invasive surgery of colorectal cancer.
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for peritoneal metastasis of colorectal cancer.
Treatment of benign anal disease，including hemorrhoid，anal fissure and anal fistula.
Member, Young Experts Committee, Chinese Society of Clinical Oncology (CSCO)
Single-cell analysis and clonal evolution of CRC.
Screening potential biomarkers for neo-adjuvant chemoradiotherapy by proteomic analysis.
The function of integrin αvβ6 in IBD pathogenesis.
Internalization and recycling of integrin αvβ6 in CRC.
Sahengbieke S#, Wang J#, Li X, Wang Y, Lai M, Wu J*. Circulating cell-free high mobility group AT-hook 2 mRNA as a detection marker in the serum of colorectal cancer patients. J Clin Lab Anal. 2018 May;32(4):e22332.
Wang J#, Sahengbieke S, Xu X, Zhang L, Xu X, Sun L, Deng Q, Wang D, Chen D, Pan Y, Liu Z, Yu S*. Gene expression analyses identify a relationship between Stanniocalcin 2 and the malignant behavior of colorectal cancer. Onco Targets Ther. 2018 Oct 18;11:7155-7168.
Wang Y#, Hu L#, Wang J, Li X, Sahengbieke S, Wu J*, Lai M*. HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. J Pathol. 2018 Dec;246(4):508-518.
Zhao Y#, Ge X#, He J, Cheng Y, Wang Z, Wang J*, Sun L*. The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis. World J Surg Oncol. 2019 May 22;17(1):85.
Zhou P#, Xiao N#, Wang J, Wang Z, Zheng S, Shan S, Wang J, Du J, Wang J*. SMC1A recruits tumor-associated-fibroblasts (TAFs) and promotes colorectal cancer metastasis. Cancer Lett. 2017 Jan 28;385:39-45.
Zhang S#, Lei R#, Wu J#, Shan J, Hu Z, Chen L, Ren X, Yao L, Wang J*, Wang X*. Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncol Lett. 2017 Nov;14(5):5719-5726.
Yu S#, Xie H, Zhang J, Wang D, Song Y, Zhang S, Zheng S, Wang J*. MicroRNA-663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1. Mol Med Rep. 2017 Dec;16(6):9707-9714.
Wu J#, Zhang S#, Shan J, Hu Z, Liu X, Chen L, Ren X, Yao L, Sheng H, Li L, Ann D, Yen Y*, Wang J*, Wang X*. Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer. Cancer Lett. 2016 Jul 1;376(2):284-92.
Wu J#, Lai M, Shao C, Wang J*, Wei JJ*. STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer. Oncol Rep. 2015 Sep;34(3):1494-502.
Wang J#, Wu J, Hong J, Chen R, Xu K, Niu W, Peng C, Liu E, Wang J, Liu S, Agrez M, Niu J*. PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin αvβ6. Cancer Lett. 2011 Dec 1;311(1):38-47.
Hong J#, Wang J#, Keleman AM, Imagawa DK, Xu K, Wang W, Liu E, Niu W, Wang J, Sun Q, Wang J, Peng C, Zhao W, Niu J*. Endoscopic Versus Surgical Treatment of Downstream Pancreatic Duct Stones in Chronic Pancreatitis. American Surgeon, 2011 Nov, 77(11): 1531-8.
Study on the molecular mechanism of colon cancer metastasis promoted by exosomes carrying integrin αvβ6. Funding Source: National Natural Science Foundation of China.
Study on the molecular mechanism of PKC and Rab proteins on regulating integrin αvβ6 trafficking. Funding Source: National Natural Science Foundation of China.
The study on the function and molecular mechanism of integrin αvβ6 in maintaining high responsiveness of colon to inflammation. Funding Source: Zhejiang Natural Science Foundation.
The study on the function and molecular mechanism of integrin αvβ6 in promoting onset and progression of colorectal diseases. Funding Source: Fundamental Research Funds for the Central Universities.