Wang Jian, M.D., Ph.D.

Department:Colorectal Surgery

Medical School:Shandong University, School of Medicine, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Comprehensive treatment and minimally invasive surgery of colorectal cancer.

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for peritoneal metastasis of colorectal cancer.

Treatment of benign anal disease,including hemorrhoid,anal fissure and anal fistula.

Professional Highlights

Professional Appointments

Member, Young Experts Committee, Chinese Society of Clinical Oncology (CSCO)

Education Experience

Research Summary

Single-cell analysis and clonal evolution of CRC.

Screening potential biomarkers for neo-adjuvant chemoradiotherapy by proteomic analysis.

The function of integrin αvβ6 in IBD pathogenesis.

Internalization and recycling of integrin αvβ6 in CRC.


Sahengbieke S#, Wang J#, Li X, Wang Y, Lai M, Wu J*. Circulating cell-free high mobility group AT-hook 2 mRNA as a detection marker in the serum of colorectal cancer patients. J Clin Lab Anal. 2018 May;32(4):e22332.

Wang J#, Sahengbieke S, Xu X, Zhang L, Xu X, Sun L, Deng Q, Wang D, Chen D, Pan Y, Liu Z, Yu S*. Gene expression analyses identify a relationship between Stanniocalcin 2 and the malignant behavior of colorectal cancer. Onco Targets Ther. 2018 Oct 18;11:7155-7168.

Wang Y#, Hu L#, Wang J, Li X, Sahengbieke S, Wu J*, Lai M*. HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. J Pathol. 2018 Dec;246(4):508-518.

Zhao Y#, Ge X#, He J, Cheng Y, Wang Z, Wang J*, Sun L*. The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis. World J Surg Oncol. 2019 May 22;17(1):85.

Zhou P#, Xiao N#, Wang J, Wang Z, Zheng S, Shan S, Wang J, Du J, Wang J*. SMC1A recruits tumor-associated-fibroblasts (TAFs) and promotes colorectal cancer metastasis. Cancer Lett. 2017 Jan 28;385:39-45.

Zhang S#, Lei R#, Wu J#, Shan J, Hu Z, Chen L, Ren X, Yao L, Wang J*, Wang X*. Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer. Oncol Lett. 2017 Nov;14(5):5719-5726.

Yu S#, Xie H, Zhang J, Wang D, Song Y, Zhang S, Zheng S, Wang J*. MicroRNA-663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1. Mol Med Rep. 2017 Dec;16(6):9707-9714.

Wu J#, Zhang S#, Shan J, Hu Z, Liu X, Chen L, Ren X, Yao L, Sheng H, Li L, Ann D, Yen Y*, Wang J*, Wang X*. Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer. Cancer Lett. 2016 Jul 1;376(2):284-92.

Wu J#, Lai M, Shao C, Wang J*, Wei JJ*. STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer. Oncol Rep. 2015 Sep;34(3):1494-502.

Wang J#, Wu J, Hong J, Chen R, Xu K, Niu W, Peng C, Liu E, Wang J, Liu S, Agrez M, Niu J*. PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin αvβ6. Cancer Lett. 2011 Dec 1;311(1):38-47.

Hong J#, Wang J#, Keleman AM, Imagawa DK, Xu K, Wang W, Liu E, Niu W, Wang J, Sun Q, Wang J, Peng C, Zhao W, Niu J*. Endoscopic Versus Surgical Treatment of Downstream Pancreatic Duct Stones in Chronic Pancreatitis. American Surgeon, 2011 Nov, 77(11): 1531-8.

Current Program

Study on the molecular mechanism of colon cancer metastasis promoted by exosomes carrying integrin αvβ6. Funding Source: National Natural Science Foundation of China.

Study on the molecular mechanism of PKC and Rab proteins on regulating integrin αvβ6 trafficking. Funding Source: National Natural Science Foundation of China.

The study on the function and molecular mechanism of integrin αvβ6 in maintaining high responsiveness of colon to inflammation. Funding Source: Zhejiang Natural Science Foundation.

The study on the function and molecular mechanism of integrin αvβ6 in promoting onset and progression of colorectal diseases. Funding Source: Fundamental Research Funds for the Central Universities.

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