Position: Vice Chair of Plastic Surgery
Medical School：Ludwig-Maximilians-Universität München (LMU, Munich University), Germany
Academic Rank：Associate Chief Physician
Anti-aging medicine, age-related diseases, skin and soft tissue tumor, breast reconstruction, trauma repair and reconstruction, facial rejuvenation, scar and keloid comprehensive therapy.
Die Sektion Chirurgische Forschung e.V. der Deutschen Gesellschaft fuer Chirurgie, Poster Preis, 2011
The 5th "Song Ruyao" Plastic Young Surgeon Forum Award, Third Prize
Council Member, Anti-aging Group, Chinese Society of Plastics and Aesthetics, 2014-present
Secretary, The 7th Editor Committee on Anti-aging Medicine of Chinese Journal of Aesthetic Medicine, 2018-present
Member, Youth Committee, Society of Hospital Management, Cross-Strait Health Exchange and Cooperation Association, 2019-present
Vica Chair, Youth Committee, Society of Medical Aesthetics and Cosmetics, Zhejiang Medical Association, 2018-present
Member, Youth Committee, Society of Plastic Surgery, Zhejiang Medical Association, 2018-present
Aging is one of the major problems of the society, and skin aging is the key scientific issue in plastic surgery research area, but it lacks strategies. According to our previous studies, Long-noncoding RNA-MALTA1 was related to skin aging, and its aging-regulation mechanism was mediated by TIMP and other cell-membrane connected proteins. However, the regulation effects of TIMPs showed multi-directional as inhibit or promote aging. As has been demonstrated by us, when TIMP1 combined with GPI, which is a cell-membrane anchor protein, they can inhibit cell proliferation, and promote apoptosis. Therefore, we hypothesize that MALTA1 regulates aging through TIMP1, which can be changed by TIMP1-GPI, and then influence the effects of anti-aging. So we plan to design the cell experiment, animal experiment, apply the trans-gene technology, gene-sequencing technology, try to figure out the mechanism of MALTA1 regulating skin aging through TIMP1-GPI, TIMP1 and other cell-membrane connected protein attending skin aging, and provide the new method for clinical anti-aging practice.
Bao Q, Pan J, Qi H, Wang L, Qian H, Jiang F, Shao Z, Xu F, Tao Z, Ma Q, Nelson P, Hu X. Aging and age-related diseases - From endocrine therapy to target therapy. Mol Cell Endocrinol. 2014; 394(1-2):115-118.
Bao Q, Niess H, Djafarzadeh R, Zhao Y, Schwarz B, Angele MK, Jauch KW, Nelson PJ, Bruns CJ. Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin. Target Oncol. 2014;9(3):251-61.
Q Bao, Y. Zhao, H. Niess, C. Conrad, B. Schwarz, K.-W. Jauch, P. J. Nelson, C. J. Bruns. Mesenchymal stem cell-based tumor-targeted therapy in gastrointestinal cancer. Stem Cells Dev. 2012; 21(13):2355-63.
Bao Q, Chen L. Thrombotic mesenteric ischemia due to aortic dissection. J Vasc Surg. 2010; 52(6):1674.
The mechanic research of Long-noncoding RNA-MALTA1 regulating the aging of skin fibroblast through TIMP1-GPI. Founding Source: National Natural Science Foundation of China.
The mechanic research on regulation of skin fibroblast aging by LncRNA-NR002819/Pygo2. Founding Source: National Natural Science Foundation of China.
Selective Targeting of Genetically Engineered Mesenchymal Stem Cells to Tumor Stroma Microenvironments Using CCL5-promoter-controlled Gene Expression Suppresses Growth of Colorectal Liver Metastasis. Founding Source: National Natural Science Foundation of Zhejiang.
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