Chen Yanxing, M.D., Ph.D.


Medical School:Tongji Medical College, Huazhong University of Science and Technology, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Cognitive impairments and aphasia, including Alzheimer's disease, frontotemporal dementia, and corticobasal syndromes.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

The role of brain insulin resistence in the development of AD.


Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse). Mol Neurobiol 2013 Apr; 47: 711-25.

Chen Y, Run X, Liang Z, Zhao Y, Dai CL, Iqbal K, Liu F, Gong CX. Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Front Aging Neurosci May 30;2014; 6: 100. 

Chen Y, Zhao Y, Dai CL, Liang Z, Run X, Iqbal K, Liu F, Gong CX. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Abeta level and microglia activation in the brains of 3xTg-AD mice. Exp Neurol 2014 Nov; 261C: 610-619. 

Chen Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Mol Neurobiol 2014 Feb; 49: 547-62.  

Chen Y, Deng Y, Zhang B, Gong CX. Deregulation of brain insulin signaling in Alzheimer's disease. Neurosci Bull 2014 Apr; 30: 282-94.  

Chen Y, Zhang J, Zhang B, Gong CX: Targeting Insulin Signaling for the Treatment of Alzheimer's Disease. Curr Top Med Chem. 2016;16(5):485-92. 

Mao YF, Guo Z, Zheng T, Jiang Y, Yan Y, Yin X, Chen Y#, Zhang B#. Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice. Aging Cell. 2016 Oct;15(5):893-902. 

Guo Z*, Chen Y*, Mao YF, Zheng T, Jiang Y, Yan Y, Yin X, Zhang B. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Sci Rep. 2017 May;7:45971. 

Chen Y, Dai CL, Wu Z, Iqbal K, Liu F, Zhang B and Gong C-X. Intranasal insulin prevents anesthesia-induced cognitive impairment and chronic neurobehavioral changes. Front Aging Neurosci. 2017, May 10; 9:136. 

Chen Y, Guo Z, Mao YF, Zheng T, Zhang B. Intranasal insulin ameliorates cerebral hypometabolism, neuronal loss, and astrogliosis in streptozotocin-induced Alzheimer’s rat model. Neurotox Res. 2018 May;33(4):716-724.

Chen Y, Zhang J, Wang J, Wang K. A Novel Variant in ABCD1 Gene Presenting as Adolescent-Onset Atypical Adrenomyeloneuropathy With Spastic Ataxia. Front Neurol. 2018. 9:271. Apri 23, doi: 10.3389/fneur.2018.00271. 

Chen Y, Yu Q, Gong CX. Molecular Connection Between Diabetes and Dementia. Adv Exp Med Biol. 2019;1128:103-131. doi: 10.1007/978-981-13-3540-2_6.

Lin C, Zhao S, Zhu Y, Fan Z, Wang J, Zhang B, Chen Y. Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease. Computational and Structural Biotechnology Journal 17 (2019) 1309–1317.

Chen Y, Lin C, Guo Z, Zhao S, Zhu Y, Huang F, Shui G, Lam SM, Pu J, Yan Y, Liu Z, Zhang B. Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer's Disease and Amnestic Mild Cognitive Impairment Patients. J Alzheimers Dis. 2020 73 (2), 811-818.

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