Xiao Qian, M.D., Ph.D.

Department:Colorectal Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician



Clinical / Research Interests

Minimally invasive surgery for colorectal disease; individualized comprehensive treatment for colorectal tumors; cancer genetics; surgery for perianal diseases.

Professional Highlights

Young Investigator Award of Chinese Society of Clinical Oncology, 2017

Professional Appointments

Education Experience

Research Summary

Biology of tumor microenvironment of colorectal cancer;

Translational research of small molecular inhibitors in K-Ras mutant colorectal cancer;

Early diagnosis of colorectal neoplasms.


Tan Y, Hu Y, Xiao Q, et al. Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway. Int J Biol Sci. 2020, 16(2): 228-238. (co-first author)

Chen L, Jiang K, Chen H, Tang Y, Zhou X, Tan Y, Yuan Y, Xiao Q, Ding K. Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway. Cancer Manag Res.2019,11:95-105. (co-corresopnding author)

Chen H, Xiao Q, Hu Y, Chen L, Jiang K, et al. ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138. J Exp Clin Cancer Res 2017, 36: 78. (co-first author)

Rucki AA, Xiao Q, Muth S, Chen J, Che X, et al. Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment. Mol Cancer Ther 2017, 16: 2399-2409. (co-first author)

Xiao Q, Zhou D, Rucki AA, Williams J, Zhou J, et al. Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation. Cancer Res 2016, 76: 5395-5404.

Hu Y, Xiao Q, Chen H, He J, Tan Y, et al. BEX2 promotes tumor proliferation in colorectal cancer. Int J Biol Sci 2017,13: 286-294. (co-first author)

Xiao Q, Hu Y, Liu Y, Wang Z, Geng H, et al. BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. PLOS ONE 2014, 9: e91782.

Current Program

Screening and identification of membrane receptors that mediates pancreatic cancer cell induced genomic methylation of cancer associated fibroblasts by direct contact. Funding Source: National Natural Science Foundation of China.

Exploration of the therapeutic value of calcification of cancer cell surface induced by targeting cea in colorectal cancer. Funding Source: Zhejiang Provincial Natural Science Foundation.

National colorectal cancer cohort study. Funding Source: National Key R&D Program of China. 

Biomarker map based colorectal cancer precision medicine. Funding Source: Key R&D Program of Zhejiang Province.

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