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Xu Jia, M.D., Ph. D.

Department：Ophthalmology

Medical School：Zhejiang University School of Medicine, China

Academic Rank：Associate Chief Physician


Appointment

Clinical / Research Interests

Congenital cataract related genes and their pathogenesis; folding and misfolding of crystallin.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Publications

Xu J, Zhao WJ, Chen XJ, Yao K, Yan YB. Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes βB2-crystallin and promotes aggregation. Biochem Biophys Res Commun. 2018 Oct 12;504(4):851-856. 

Zhao WJ, Xu J, Chen XJ, Liu HH, Yao K, Yan YB. Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding. Int J Biol Macromol. 2017 Oct;103:764-770.

Zheng XY, Xu J, Li W, Li SS, Shi CP, Zhao ZY, Mao JH, Chen X. Frosted Branch Angiitis in Pediatric Dyskeratosis Congenita: A Case Report. Medicine (Baltimore). 2016 Mar;95(12):e3106.

Chen PQ, Han XM, Zhu YN, Xu J. Comparison of the anti-inflammatory effects of  fluorometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery. Int J Ophthalmol. 2016 Nov 18;9(11):1619-1623.

Xu J, Wang S, Zhao WJ, Xi YB, Yan YB, Yao K. The congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin. PLoS One. 2012;7(12):e51200.

Current Program

The importance of conserved tryptophans at βB2-crystallin stability and their photoprotective mechanism. Funding Source: National Natural Science Foundation of China.

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