Chen Zhigang, M.D., Ph.D.

DepartmentBreast Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Clinical / Research Interests

Individualized treatment of breast cancer; minimally invasive surgery of breast caner.

Professional Highlights

Professional Award for Medicine and Health Science and Technology Innovation of Zhejiang Province, First Prize

Professional Appointments

Member, Zhejiang Institute of Stem Cell and Regenerative Medicine, 2015-present

Member, Zhejiang Institute of clinical immunity, 2014-present

Education Experience

Research Summary

1. Molecular mechanisms of cancer stem cells maintaining self-renewal

2. use cutting-edge genetic technologies to study the gene regulation in cancer stem cell

3. The role and mechanisms of Fas/FasL in cancer


Huang Qi, Chen Zhigang, Cheng Pu, Huang Yucheng, Wang Zhen, Jiang Zhou,Yang Chenghui, Pan Jun, Qiu Fuming, Huang Jian, 2019, LYRM2 directly Regulates Complex IActivity to Support Tumor Growth in Colorectal Cancer by Oxidative Phosphorylation, Cancer Lett. 455:36-47. 

Zhigang Chen, Wenlu, Li, Fuming Qiu, Qi Huang, Pu Cheng, Cho Low, Yikun Guo, Xinchi Yi,Wenteng Chen, Yongpin Yu, Dong Kong, and Jian Huang, 2018, Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer, Theranostics, 8(16):4447-4461.

Li Wenlu, Chen Zhigang, Yuan Jing, Yu Zhanyang, Cheng Chongjie, Zhao Qiucheng, Huang Lena, Hajjar KA, Chen Zhong, Lo EngHua, Dai Haibin, Wang Xiaoying, 2018, Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability. J Cereb Blood Flow Metab. Epub ahead of print. 

Ye, Jun, Wu, Dang, Wu, Pin, Chen, Zhigang(*), Huang, Jian(*), 2014, The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment. TUMOR BIOLOGY, 35(5):3945-3951. 

Wu, Pin, Wu, Dang, Ni, Chao, Ye, Jun, Chen, Wuzhen, Hu, Guoming, Wang, Zhen,Wang,Changrong, Zhang, Zhigang, Xia, Wenjie, Chen, Zhigang, Wang, Ke, Zhang, Tao, Xu,Jinghong, Han, Yuehua, Zhang, Ting, Wu, Xianguo, Wang, Jianwei, Gong, Weihua, Zheng, Shu,Qiu, Fuming, Yan,Jun, Huang, Jian, 2014,γδ T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity, 40(5):785-800.

Current Program

Identification of the key target proteins interacting with Aspirin in inhibiting colon cancer stem cells selectively by using chemical modified Aspirin and CRISPR technology (PI). Funding Source: Natural Science Foundation of Zhejiang (Y16H160065), 2016-2019.

The role and mechanisms of Fas controlled by the acetylation of histone in maintaining the properties of colorectal cancer stem cells based on optogenetics and CRISPR technology (PI). Funding Source: National Natural Science Foundation of China (81502564), 2015-2018.

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