Department：Breast Surgery
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Physician
Diagnosis and treatment of benign and malignant breast diseases, especially the comprehensive treatment of breast cancer.
Youth Committee Member, Oncology Committee, Zhejiang Medical Association
Multidrug resistance is a serious problem in the treatment of breast cancer. Dr. He's previous study shows that miR-944 regulates the cisplatin resistance in breast cancer. AS miRNAs regulate genes expression through modulation of post-transcriptional activity, by binding to the 3’-untranslated region (UTR) of multiple target mRNAs in a sequence-specific manner, Dr. He speculates that miR-944 is associated with multidrug resistance by targeting multiple genes besides BNIP3. He plans to continue the investigation by using a variety of cellular and molecular biological technology, detecting the expression of the target genes, trying to reveal the pathway modulated by miR-944 involved in multi-chemoresistance, and provide a theoretical basis for the research of new target in prediction and reverse of multidrug resistance of breast cancer.
Haifei He, Ju Yao, Yingxin Zhang, Yidan Chen, Kaifeng Wang, Robert J. Lee,Bo Yu, Xiaomin Zhang. Solid lipid nanoparticles as a drug delivery system to across the blood-brain barrier. Biochemical and Biophysical Research Communications. 2019:385-390.
He, Haifei; Tian, Wei; Chen, Hailong; Jiang, Kai. MiR-944 functions as a novel oncogene and regulates the chemoresistance in breast cancer. Tumour Biol. 2016 Feb;37(2):1599-1607.
He, Haifei; Tian, Wei; Chen, Hailong; Deng, Yongchuan. MicroRNA-101 sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis via targeting Mcl-1. Mol Med Rep. 2016 Feb;13(2):1923-1929.
The role of everolimus reverse endocrine resistance of breast cancer mediated by ER-α36. Funding Source: Medical and Health Project of Zhejiang Province.
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