Deng Boya, M.D., Ph.D.

Department:Gynecology

Medical School:China Medical University, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Dr. Deng devoted herself to the clinical diagnosis and treatment of the gynecology oncology (including ovarian tumor, endometrial cancer, cervical cancer), and its surgery, chemotherapy and precision medicine, especially microinvasive laparoscopic surgery.


Professional Highlights

Oral presentation on the basic research (Glycosylation of the ER-α), AACR meeting, Chicago, USA, 2018.

Oral presentation on oncoimmunology research, JCA meeting, Osaka, Japan, 2018.

Professional Appointments

Education Experience

Research Summary

To understand the molecular mechanisms in response to immune check point inhibitor therapy(anti-PD-1/anti-PD-L1) in bladder cancer patients through analyzing the T-cell receptor diversity together with whole exon sequencing in cancer tissue.

To get the onco-gene by whole exon sequencing of the head and neck cancers and predict the onco-protein to make peptides, and pulse with the APC cells to get specific CD8+ T cell clusters, by analyzing the TCR, design and make the engineer T cells to specifically kill the tumor cells with the oncoprotein. 

For the first time prescribed the mechanism of GALNT6 glycosylates Estrogen receptor-α, through which promoting breast cancer cell proliferation and cancer progression.

By using HIPEC treatment together with PARP inhibitor and immune therapy, to improve the prognosis of recurrent ovarian cancer patients and to invest the molecular mechanism.

Publications

Boya Deng, Tarhan YE, Ueda K, Ren L, Katagiri T, Park JH, Yusuke Nakamura*. Critical Role of Estrogen Receptor Alpha O-Glycosylation by N-Acetylgalactosaminyltransferase 6 (GALNT6) in Its Nuclear Localization in Breast Cancer Cells. Neoplasia. 2018;20(10):1038-44.

Boya Deng, Jae-Hyun Park, Lili Ren, Poh Yin Yew, Kazuma Kiyotani, Tatjana Antic, Kelly O’Connor, Peter H. O'Donnell, Yusuke Nakamura*. CD8 lymphocytes in tumors and non-synonymous mutational load correlate with prognosis of bladder cancer patients treated with immune check point inhibitors. (Cancer reports)

Boya Deng, Jae-Hyun Park, Daigo Yataro, Yusuke Nakamura*.Knockdown of TTK in ovarian cancer cells causes dysfunction of cell division, multinuclear cell formation and cell death. Cancer science. Jan 2018 109,1006.

Boya Deng*, Siyang Zhang,Yi Zhang, Yuan Miao,Xiangkai,Meng, Guo Kejun. Knockdown of Tripartite Motif Containing 28 suppresses the migration, invasion and epithelial–mesenchymal transition in ovarian carcinoma cells through down-regulation of Wnt/β-catenin signaling pathway. Neoplasma, 2017;64(6):893-900.

Boya Deng*, Yi Zhang, Siyang Zhang, Fang Wen, Yuan Miao, Guo Kejun. MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7. Tumor Biology. 2015, 36(10).

Boya Deng*, Siyang Zhang, Yuan Miao,Yi Zhang, Fang Wen, Guo Kejun. Down-regulation of Frizzled-7 expression inhibits migration,invasion,and epithelial mesenchymal transition of cervical cancer cell lines. Medical Oncology. 2015, 32(4). 

Boya Deng, Yang Zhao, Wenfeng Gou, Shuo Chen Xiaoyun Mao, Yasuo Takano, Huachuan Zheng*. Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma. Tumor Biology. 2013, 34(5), 2617-2624. 

Boya Deng, Siyang Zhang, Yuan Miao, Zhuang Han, Xiaoli Zhang, Fang Wen* and Yi Zhang*. Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrinα5β1 and phosphorylating FAK and paxillin. Journal of Experimental & Clinical Cancer Research. 2012, 31(19).


Current Program

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