Zheng Chao, M.D.

Position:Chair of Endocrinology

Department:Endocrinology

Medical School:Central South University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Mechanism and novel intervention targets of diabetic microvascular disease.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Publications

Hang Zhang, Jing-Jing Zuo, Si-Si Dong, Yuan Lan, Chen-Wei Wu, Guang-Yun Mao, Chao Zheng. Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study [J]. J Diabetes Res. 2020 Mar 2;2020:3049098. doi: 10.1155/2020/3049098.

Tan Y#, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020 Feb 20;. doi: 10.1038/s41569-020-0339-2.

Chao zheng, Wu Luo, Lan Huang, Weihui Yu, Xueting Hu, Xinfu Guan, Yan Cai, Chunpeng Zou, Haimin Yin, Zheng Xu, Chao Zheng, and Guang Liang, Yi Wang. Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice. Cell Death Dis. 2019 Nov 7;10(11):848.

Hou X, Wang D, Zuo J, Li J, Wang T, Guo C, Peng F, Su D, Zhao L, Ye Z, ZhangH, Zheng C, Mao G*. Development and validation of a prognostic nomogram for HIV/AIDS patients who underwent antiretroviral therapy: Data from a China population-based cohort. EBioMedicine. 2019 Oct 5. pii: S2352-3964(19)30658-9. 

Luo W, Huang L, Wang J, Zhuang F, Xu Z, Yin H, Qian Y, Liang G, Zheng C, Wang Y*. Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes. J Endocrinol. 2019 Sep 1;242(3):199-210. 

Su X, Xu J, Zheng C. The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocr Disord. 2019 Jul 17;19(1):76.

Tu Y, Wang L, Wei L, Xu Y, Han X, Han J, Yu H, Zheng C, Bao Y, Jia W*.Cost-Utility of Laparoscopic Roux-en-Y Gastric Bypass in Chinese Patients with Type 2 Diabetes and Obesity with a BMI ≥ 27.5 kg/m2: a Multi-Center Study with a 4-Year Follow-Up of Surgical Cohort. Obes Surg. 2019 Jul 23. 

Wang D, Jin M, Zhao X, Zhao T, Lin W, He Z, Fan M, Jin W, Zhou J, Jin L, Zheng C*, Jin H, Zhao Y, Li X, Ying L, Wang Y, Zhu G, Huang Z. FGF1(ΔHBS) ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation. Cell Death Dis. 2019 Jun 12;10(6):464. 

Qian J, Chen X, Chen X, Sun C, Jiang Y, Qian Y, Zhang Y, Khan Z, Zhou J, Liang G, Zheng C. Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-κB and inflammatory responses in acute lung injury in mice. Toxicol Lett. 2019 May 15;306:53-60.

Xu J, Zhou X, Zheng C. The geriatric nutritional risk index independently predicts adverse outcomes in patients with pyogenic liver abscess. BMC Geriatr. 2019 Jan 16;19(1):14. 

Zheng C, Liu Z. Vascular function, insulin action, and exercise: an intricate interplay. Trends Endocrinol Metab. 2015 Jun;26(6):297-304. 

Li CY, Wang LX, Dong SS, Hong Y, Zhou XH, Zheng WW, Zheng C. Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of  Nitric Oxide (NO). Med Sci Monit Basic Res. 2018 Jan 8;24:1-9. 

Peng K, Pan Y, Li J, Khan Z, Fan M, Yin H, Tong C, Zhao Y, Liang G, Zheng C. 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes. Sci Rep. 2016 Nov 14;6:37160. 

Fan M, Li W, Wang L, Gu S, Dong S, Chen M, Yin H, Zheng J, Wu X, Jin J, Jiang X, Cai J, Liu P, Zheng C. Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis. Endocrine. 2016 Aug;53(2):381-94.

Chen MD, Dong SS, Cai NY, Fan MD, Gu SP, Zheng JJ, Yin HM, Zhou XH, Wang LX, Li CY, Zheng C. Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2016 Jan 29;16:28. 

Fang Q, Wang J, Wang L, Zhang Y, Yin H, Li Y, Tong C, Liang G, Zheng C. Attenuation of inflammatory response by a novel chalcone protects kidney and heart from hyperglycemia-induced injuries in type 1 diabetic mice. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):179-91.

Zheng C, Dalla Man C, Cobelli C, Groop L, Zhao H, Bale AE, Shaw M, Duran E,Pierpont B, Caprio S, Santoro N. A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity. Obesity (Silver Spring). 2015 May;23(5):1022-9. 


Current Program

Coupling of the vasodilation and insulin sensitization actions of glucagon-like peptide 1 receptor agonist: A mechanistic study. Funding Source: National Natural Science Funding of China.

New Effect and Potential Mechanism of 1,25(OH)2D3 in Improving Skeletal Insulin Resistance. Funding Source: National Natural Science Funding of China.

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