Department:Clinical Laboratory Medicine
Medical School:Zhejiang University School of Medicine, China
Academic Rank:Associate Chief Technician
Isolation, identification, and antimicrobial susceptibility testing of clinical pathogens.
Providing assistant diagnosis for infectious diseases.
Antimicrobial resistance mechanisms, including resistance of carbapenem, β-lactamase inhibitors, and colistin in enterobacteriaceae, and linezolid resistance in enterococci and staphylococci;
Molecular mechanisms of dissemination of two resistance genes, blaCTX-M-199 and optrA.
Cai Jiachang, Stefan Schwarz, Chi Dan, et al. Faecal carriage of optrA-positive enterococci in asymptomatic healthy humans in Hangzhou, China. Clinical Microbiology and Infection. 2019; 25(5): 630.e1-630.e6.
Cai Jiachang, Cheng Qipeng, Shen Yingbo, et al. Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid. Antimicrobial Agents and Chemotherapy. 2017; 61(7), e00562-17.
Cai Jiachang, Wang Yang, Stefan Schwarz, et al. High detection rate of the oxazolidinone resistance gene optrA in Enterococcus faecalis isolated from a Chinese anorectal surgery ward. International Journal of Antimicrobial Agents. 2016; 48(6): 757-759.
Cai Jiachang, Wang Yang, Stefan Schwarz, et al. Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010-2014. Clinical Microbiology and Infection. 2015; 21(12): 1095.e1-e4.
Cai Jiachang, Hu Yanyan, Zhou Hongwei, et al. Dissemination of the same cfr-carrying plasmid among methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci isolates in China. Antimicrobial Agents and Chemotherapy. 2015; 59(6): 3669-3671.
Mechanisms of interspecific and intergeneric transmission of the KLDP variant of linezolid resistance gene optrA . Funding Source: National Natural Science Foundation of China (81971988), 2020-2023.
Epidemiological characteristics and transmission mechanism of a novel extended-spectrum β-lactamases gene blaCTX-M-199 mediating resistance to sulbactam and tazobactam in Enterobacteriaceae. Funding Source: Natural Science Foundation of Zhejiang (LY18H200001), 2018-2020.