Cai Jiachang, Ph.D.

Department:Clinical Laboratory Medicine

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Technician

Clinical / Research Interests

Isolation, identification, and antimicrobial susceptibility testing of clinical pathogens.

Providing assistant diagnosis for infectious diseases.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Antimicrobial resistance mechanisms, including resistance of carbapenem, β-lactamase inhibitors, and colistin in enterobacteriaceae, and linezolid resistance in enterococci and staphylococci;

Molecular mechanisms of dissemination of two resistance genes, blaCTX-M-199 and optrA.


Cai Jiachang, Stefan Schwarz, Chi Dan, et al. Faecal carriage of optrA-positive enterococci in asymptomatic healthy humans in Hangzhou, China. Clinical Microbiology and Infection. 2019; 25(5): 630.e1-630.e6.

Cai Jiachang, Cheng Qipeng, Shen Yingbo, et al. Genetic and functional characterization of blaCTX-M-199, a novel tazobactam and sulbactam resistance-encoding gene located in a conjugative mcr-1-bearing IncI2 plasmid. Antimicrobial Agents and Chemotherapy. 2017; 61(7), e00562-17.

Cai Jiachang, Wang Yang, Stefan Schwarz, et al. High detection rate of the oxazolidinone resistance gene optrA in Enterococcus faecalis isolated from a Chinese anorectal surgery ward. International Journal of Antimicrobial Agents. 2016; 48(6): 757-759.

Cai Jiachang, Wang Yang, Stefan Schwarz, et al. Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010-2014. Clinical Microbiology and Infection. 2015; 21(12): 1095.e1-e4.

Cai Jiachang, Hu Yanyan, Zhou Hongwei, et al. Dissemination of the same cfr-carrying plasmid among methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci isolates in China. Antimicrobial Agents and Chemotherapy. 2015; 59(6): 3669-3671.

Current Program

Mechanisms of interspecific and intergeneric transmission of the KLDP variant of linezolid resistance gene optrA . Funding Source: National Natural Science Foundation of China (81971988), 2020-2023. 

Epidemiological characteristics and transmission mechanism of a novel extended-spectrum β-lactamases gene blaCTX-M-199 mediating resistance to sulbactam and tazobactam in Enterobacteriaceae. Funding Source: Natural Science Foundation of Zhejiang (LY18H200001), 2018-2020.

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