Position：Vice Chair of Clinical Research Center
Department：Clinical Research Center
Medical School：Shanghai Jiaotong University, School of Medicine, China
Academic Rank：Researcher, Associate Professor
Member, International Society of Heart Research
Dr. Zhu's research is mainly focused on how mitochondria integrity (morphological structure and function) is adaptive to the various stress condition and plays its role in cell biology, especially how it is involved in heart failure.
Dr. Zhu's team has demonstrated that mild ROS generation signal can serve as preconditioned signal which in turn activate a series of protective signal pathways against following severe ischemic attack.
They have also shown that mitochondria dynamics are indeed closely involved in the protection for the cardiomyocytes by maintaining the integrity of the mitochondria for their better performance in stressed conditions.
Yi Yang, Zhenhai Fu, Wei Zhu, Huizhu Hu, Jian'an Wang. Application of optical tweezers in cardiovascular research: More than just a measuring tool. Front Bioeng Biotechnol. 2022 Sep 6;10:947918. doi: 10.3389/fbioe.2022.947918. eCollection 2022.
Xin P, Zhu W, Li J, et al. Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning [published correction appears in Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H957]. Am J Physiol Heart Circ Physiol. 2010;298(6):H1819-H1831. doi:10.1152/ajpheart.01102.2009.
Tao J, Zhu W, Li Y, et al. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion. Am J Physiol Heart Circ Physiol. 2011;301(4):H1471-H1486. doi:10.1152/ajpheart.00097.2011.
Wei M, Xin P, Li S, et al. Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circ Res. 2011;108(10):1220-1225. doi:10.1161/CIRCRESAHA.110.236190.
Hu X, Chen P, Wu Y, et al. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34(7):1846-1858. doi:10.1002/stem.2391.
Li YG, Han BB, Li F, et al. High Glucose Induces Down-Regulated GRIM-19 Expression to Activate STAT3 Signaling and Promote Cell Proliferation in Cell Culture. PLoS One. 2016;11(4):e0153659. Published 2016 Apr 21. doi:10.1371/journal.pone.0153659.
Hu H, Nan J, Sun Y, et al. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A. 2017;114(45):11908-11913. doi:10.1073/pnas.1704723114.
Nan J, Hu H, Sun Y, et al. TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res. 2017;121(4):392-410. doi:10.1161/CIRCRESAHA.117.311143.
Dr. Zhu's lab is supported by National Natural Science Foundation and is mainly focused on the phenomenon of mitochondrial UPR that carries the signal from the nucleus, as well as the interactions between mitochondria and other organelles, trying to discover novel signaling molecules that can serve as potential therapeutic targets for treating patients with cardiovascular diseases.
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iao_sahzu@zju.edu.cn
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