Department：Pharmacy
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Pharmacist
Respiratory pharmacology, anti-inflammatory immunopharmacology, and hospital pharmacy.
Dr. Yao has been engaged in the pathophysiology and experimental treatment of respiratory diseases such as asthma, COPD, acute lung injury, lung cancer, etc., especially the role and its mechanism of Rho small G protein Rac and its subtypes, which may be involved in neutrophils in lung injury or regulation of endothelial permeability on tumor cell metastasis in lung tumors. At present, the focus is on the role of the small G protein RhoA in allergic diseases such as eosinophil chemotaxis.
Endothelial Rac1 is essential for hematogenous metastasis to the lung. Oncotarget. 2015;6(19):17501-17513.
Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice. Biochim Biophys Acta. 2011; 1810(7):666-74.
Cyptoporus polysaccharide prevents lipopolysaccharide-induced acute lung injury associated with down-regulating Toll-like receptor 2 expression. J Ethnopharmacol. 2011; 137(3):1267-74.
The regulation of Rac subtype on the role and mechanism of lung injury in asthma. Funding Source: National Natural Science Foundation of China.
The study of Rac1 on the molecular mechanism and significance by regulating Sonic Hedgehog signal. Funding Source: National Natural Science Foundation of China.
The study of CYP450 epioxidase pathway as a new target on the treatment of airway remodeling in asthma. Funding Source: National Natural Science Foundation of China.
The regulation of Rac1 signal on the molecular mechanism of cigarette-induced airway epithelial-mesenchymal cell transformation. Funding Source: National Natural Science Foundation of China.
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Zhejiang University School of Medicine
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iao_sahzu@zju.edu.cn
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