Wang Xingang, M.D.

Position: Vice Chair of Burns

Department:Burns

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Thermal burn

Chemical burn

Nutrition support

Wound repair and reconstruction

Chronic ulcers

Venous ulcers

Arterial ulcers

Diabetes foot ulcers

Laser therapy

Scar treatment

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Second Prize, 2018

Zhejiang Medicine and Health Award, Second Prize, 2018

Zhejiang Medicine and Health Award, First Prize, 2016

Zhejiang Medicine and Health Award, Third Prize, 2016

Zhejiang Medicine and Health Award, Third Prize, 2015

Professional Appointments

Youth Committee Member, Chinese Society of Burn Surgery, Chinese Medical Association

Youth Committee Member, Trauma Surgeons Branch, Chinese Medical Doctor Association

Member and Secretary, Trauma Surgeons Branch, Zhejiang Medical Doctor Association

Communications Editor, Chinese Journal of Burn


Education Experience

Research Summary

Repairing the severe skin defects by developing novel biomaterial scaffolds.

Trying to modify the scaffolds by chemical loading, gene modification and some other methods for the delivery of bioactive factors to promote the angiogenesis of scaffold.

Improving the recovery efficiency of chemical burns, especially for hydrofluoric (HF) burns, including cardiac toxicology of fluoride ions, CRRT for chemical burns, intravenous or intra-arterial infusion of gluconate calcium for patients with HF burns.


Publications

Wang Xingang, Hu Xinlei, Sun Huafeng, et al. Applications of Knitted Mesh Fabrication Techniques to Scaffolds for Tissue Engineering and Regenerative Medicine. Journal of the mechanical behavior of biomedical materials, 2011,4(7):922-932.

Xinlei Hu, Huafeng Sun, Chunmao Han, Xingang Wang, Weijie Yu. Topically applied rhGM-CSF for the wound healing: A systematic review. Burns, 2011,37(5):729-741. 

Wang Xingang, Li Qiyin, Hu Xinlei, et al. Fabrication and characterization of poly(L-lactide-co-glycolide) knitted mesh-reinforced collagen-chitosan hybrid scaffolds for dermal tissue engineering. Journal of mechanical behavior of biomedical materials, 2012,8:204-215. 

Li Qiyin, Wang Xingang, Hu Xinlei, et al. A survey of diabetic foot patients with hospitalized amputations performed in a medical center over five years: limitations and lessons learnt. The International Journal of Lower Extremity Wounds, 2012, 11(3):194-200. 

Huafeng Sun, Xingang Wang, Xinlei Hu, et al. Promotion of Angiogenesis by Sustained Release of rhGM-CSF from heparinized Collagen/Chitosan Scaffolds. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2012, 100(3): 788-798. 

Xinlei Hu, Weijie Yu, Huafeng Sun, Xingang Wang, Chunmao Han. Epidermal cells delivered for cutaneous wound healing. Journal of Dermatological Treatment, 2012;23(3):224-237. 

You Chuangang, Han Chunmao, Wang Xingang, et al. The Progress of Silver Nanoparticles in the Antibacterial Mechanism, Clinical Application and Cytotoxicity. Molecular Biology Reports, 2012, 39(9):9193-9201. 

Yurong Zheng, Zhanzeng Feng, Chuangang You, Yunyun Jin, Xinlei Hu, Xingang Wang, Chunmao Han. In vitro evaluation of Panax notoginseng Rg1 released from collagen/chitosan-gelatin microsphere scaffolds for angiogenesis. Biomedical Engineering Online, 2013, 12:134. 

Wang Xingang, You Chuangang, Hu Xinlei, et al. The roles of knitted mesh-reinforced collagen-chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats. Acta Biomaterialia, 2013, 9(8): 7822-7832. 

Wang Xingang, Han Chunmao. The roles of topical negative pressure in deep burn wounds treated by dermal substitution. Wound Repair and Regeneration. 2013, 21(6): 904.

Chuangang You, Xingang Wang, Yurong Zheng, Chunmao Han. Three types of dermal grafts in rats: The importance of mechanical strength and structural design. Biomedical Engineering Online, 2013, 12:125. (Co-first author) 

Zhang Yuanhai, Ni Liangfang, Wang Xingang, et al. Clinical arterial infusion of calcium gluconate: the preferred method for treating hydrofluoric acid burns of the distal human limbs. International Journal of Occupational Medicine and Environmental Health. 2014, 27(1): 104-113. (Corresponding author)

Wang Xingang, Hu Xinlei, You Chuangang, Han Chunmao. Delivery of epithelial autografts and cutaneous wound healing in burn patients. Burns, 2014, 40(1): 166-168. 

Wang Xingang, Zhang Yuanhai, Han Chunmao. Topical negative pressure improves the autograft take by altering the nutrient diffusion: A hypothesis. Medical Science Monitor, 2014, 20: 61-63. (Corresponding author) 

Wang Xingang, Han Chunmao. Re-emphasizing the role of copious water irrigation in the first aid treatment of chemical burns. Burns, 2014, 40(4): 779-780. 

Xingang Wang, Yuanhai Zhang, Chunmao Han. Angiogenin, an angiogenic factor with potential for tissue engineering applications. Wound Repair and Regeneration. 2014, 22(2): 288-289. 

Wang Xingang, Fang Quan, You Chuangang, Han Chunmao. Construction of skin substitutes using minced split-thickness autografts and biodegradable synthetic scaffolds. Burns, 2014, 40(6): 1232-1233.

Wang Xingang, Zhang Yuanhai, Ni Liangfang, You Chuangang. Ye Chunjiang, Han Chunmao. A review of treatment strategies of hydrofluoric acid burns: current status and further prospect. Burns. 2014, 40(8):1447-1457. 

Zhang Yuanhai, Wang Xingang, Liu Liping, et al. Management of a patient with faciocervical burns and inhalational injury due to hydrofluoric acid exposure. The International Journal of Lower Extremity Wounds, 2014, 13(2):155-159. (Corresponding author) 

Zhang Yuanhai, Wang Xingang, Ni Liangfang, et al. Management of a patient with thermal burns and para-nitrochlorobenzene poisoning. International Journal of Occupational Medicine and Environmental Health. 2014, 27(5):882-887. (Corresponding author)

Zhang Yuanhai, Wang Xingang, Ye Chunjiang,et al. The clinical effectiveness of the intravenous infusion of calcium gluconate for treatment of hydrofluoric acid burn of distal limbs. Burns, 2014, 40(4): e26-e30. 

Yurong Zheng, Xingang Wang, Liping Zhang, et al. Successful treatment of a patient with complicated diabetic foot wound: A case report. The International Journal of Lower Extremity Wounds, 2014, 13(2): 140-146. 

Weibin Ma, Xianyan Yang, Liang Ma, Xingang Wang,et al. Fabrication of bioactive glasses-introduced nanofibrous membranes with multifunctions potentially for wound dressing. RSC Advances, 2014, 4, 60114–60122. 

Shi Haifei, Wang Xingang, Wu Shoucheng, et al. The effect of collagen-chitosan porous scaffold thickness on dermal regeneration in a one-stage grafting procedure. Journal of mechanical behavior of biomedical materials, 2014, 29: 114-125. 

Zhang Yuanhai, Wang Xingang, Liu Liping, et al. Hypercalcemic crisis in a young man with extensive burns caused by heated CaCl2 solution: A case report. Burns, 2014, 40(3): e12-e14. 

Zhang Yuanhai, Wang Xingang, Komal Sharma, et al. Injuries following a serious hydrofluoric acid leak: first aid and lessons. Burns, 2015, 41(7): 1593-1598. 

Zhang Yuanhai, Wang Xingang, Ni Liangfang, et al. A rare case of chemical burns caused by a mixture of sulphuric acid and hydrofluoric acid. Clinical Toxicology. 2015, 53(7): 785. (Corresponding author) 

Zhanzeng Feng, Yurong Zheng, Chuangang You, Yunyun Jin, Xingang Wang,et al. Basic investigation into the present burn care system in China: burn units, doctors, nurses, beds and special treatment equipment. Burns, 2015, 41(2):279-288.

Hu hang, Jiang Hongfei, Ren Haitao, Hu Xinlei, Wang Xingang, Han Chunmao. AGEs and chronic subclinical inflammation in diabetes: disorders of immune system. Diabetes Metabolism Research and Reviews, 2015, 31(2): 127-137. 

Shao Huawei, Luo Ru, Wang Xingang, Pan Xuanliang, Chen Guoxian. Management of a patient with minor burns and severe sepsis. Journal of Wound Care, 2015, 24(2):73-4, 77-78. 

Songxue Guo, Hanlei Zhou, Chunln Huang, Chuangang You, Quan Fang, Pan Wu, Xingang Wang, Chunmao Han. Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis. Marine Drugs. 2015, 13: 2105-2123. 

Songxue Guo, Yunyun Jin, Quan Fang, Chuangang You, Xingang Wang, Chunmao Han. Benefit effect of Hydrogen Rich Saline on Early Burn Wound Progression in Rats. Plos One. 2015, 10 (4): e0124897. 

Songxue Guo, Quan Fang, Chuangang You, Yunyun Jin, Xingang Wang, Xinlei Hu, Chunmao Han. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. Journal of Translational Medicine. 2015, 13:183. 

Yuanhai Zhang, Xingang Wang, Liangfang Ni, et al. Early and Thorough Wound Debridement Is Crucial for Treatment of Patients With Thermal Burns and para-Chloronitrobenzene Poisoning. The International Journal of Lower Extremity Wounds. 2016, 15(3): 255-259.

Xingang Wang, Pan Wu, Xiuyuan Hu,et al. Polyurethane membrane/knitted mesh-reinforced collagen-chitosan bilayer dermal substitute for repairing the full-thickness skin defects in the two-step procedure. Journal of the Mechanical Behavior of Biomedical Materials. 2016, 56: 120-133. 

Yunanhai Zhang, Xingang Wang, Liangfang Ni, Chunmao Han. Subcutaneous injection of epidermal growth factor for skin hydrofluoric acid burns. International Wound Journal, 2016,13(5):1023. (Corresponding author)

Zhao Ruiyi, Chen Chunfang, Jin Jingfen, Komal Sharma, Jiang Nan, Shentu Yingqin, Wang Xingang. Clinical evaluation of the use of an intracardiac electrocardiogram to guide the tip positioning of peripherally inserted central catheters. International Journal of Nursing Practice, 2016, 22(3): 217-223. 

Chunjiang Ye, Xingang Wang, Yuanhai Zhang,et al. Ten-year epidemiology of chemical burns in Western Zhejiang Province of China. Burns, 2016. 42(3):668-674. 

Yuanhai Zhang, Jianfen Zhang, Xingang Wang. Treatment of hydrofluoric acid burns in fingers. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2016. 69(3):436-437. 

Yuanhai Zhang, Chunmao Han, Xuguang Qiu, Liangfang ni, Xinxing Mao, Xingang Wang. Response to "Chemical injuries caused by the hydrofluoric acid leak". Burns, 2016, 42(3):706-708. 

Yuanhai Zhang, Jianfen Zhang, Xinhua Jiang, Liangfang Ni, Chunjiang Ye, Chunmao Han, Komal Sharma, Xingang Wang. Hydrofluoric acid burns in the western Zhejiang Province of China: A 10-year epidemiological study. Journal of Occupational Medicine and Toxicology. 2016, 11:55. 

Hanlei Zhou, Chuangang You, Xingang Wang, et al. The progress and challenges for dermal regeneration in tissue engineering. Journal of Biomedical Materials Research Part A, 2017, 105(4):1208-1218. 

Chuangang You, Qiong Li, Xingang Wang, et al. Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation. Scientific Reports, 2017, 7(1):10489.

Yuanhai Zhang, Xingang Wang, Yuezhen Liu, et al. Management of a rare case with severe hydrofluoric acid burns: The important roles of neutralizers and continuous renal replacement therapy (CRRT). The International Journal of Lower Extremity Wounds. 2017, 16 (4): 289-295. 

Yong Liu, Pan Wu, Jon Kee Ho, Haiping Hua, Haojiao Chen, Ying Cen, Songxue Guo, Chunmao Han, Xingang Wang. Epidemiology of bus fires in mainland China from 2006 to 2015. Burns, 2018, 44(4):995-999. 

Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang*, Chunmao Han*. Non-viral gene delivery systems for tissue repair and regeneration. The Jounal of Translatonal Medcine. 2018, 16:29. (The first corresponding author). 

Haifei Shi, Tingting Weng, Chunmao Han, Xingang Wang. Improved dermal regeneration using a combination of dermal substitutes and dermal fibroblast optimisation: A hypothesis. Medical Science Monitor. 2018, 24: 5457-5461 (Corresponding author)

Pan Wu, Xingang Wang, Ronghua Jin, et al. A 27-year follow up for a patient with 100% total body surface area burn. Journal of Burn Care and Research. 2018, 39(2):302-307. 

Ronghua Jin#, Pan Wu, Jon Kee Ho, Xingang Wang, Chunmao Han*. Five-year epidemiology of liquefied petroleum gas-related burns. Burns, 2018, 44(1):210-217. 

Hanlei Zhou, Huawei Shao, Jon Kee Ho, Xingang Wang, Chunmao Han, Guoxian Chen. Rare Skin Fistulas Relating to Ascending Colonic Carcinoma: An Unusual Mode of Revelation. The International Journal of Lower Extremity Wounds. 2018, 17(1): 48-53.


Current Program

Double Gene-activated dermal scaffolds sequentially mediate the process of angiogenesis by regullating the co-expression of VEGF and angiopoietin-1. Funding Source: National Natural Science Foundation of China.

Gene-activated dermal substitutes mediate early-satge angiogenesis by regulating the local expression of angiogenin. Funding Source: National Natural Science Foundation of China.

Construction and translation of Knitted mesh reinforced dermal substitutes. Funding Source: National Key Reserach and Development Project of China.

Construction and characterization of Knitted mesh reinforced dermal scaffolds. Funding Source: Natural Science Foundation of Zhejiang.

Gene-activated dermal substitutes mediate early-satge angiogenesis by regulating the local expression of GM-CSF. Funding Source: Zhejiang Medical and Health Science and Technology Project.


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