Bai Ge, Ph.D.


Medical School:Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China

Academic Rank:Professor

Clinical / Research Interests

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Research Summary

Normal behavioral functions rely on precise and complex neural circuits linking large ensembles of neurons. Abnormal circuit development, neurodegenerative diseases and neural injury are detrimental to the performance of the nervous system. However, the regenerative capacity of mature mammalian central nervous system (CNS) is extremely limited, creating a major clinical challenge. 

The long-term objectives : 

(1) To study the molecular mechanisms controlling the assembly of motor circuits; 

(2) To understand how neural miswiring and degenerative disorders affect motor circuit function and behavior; 

(3) To develop new therapeutic strategies for effective maintenance and repair of motor circuits in pathologic conditions.


Hai-Lin Dong, Hao-Ling Cheng, Ge Bai, Ying Shen, Zhi-Ying Wu*. Novel GDAP2 pathogenic variants cause autosomal recessive spinocerebellar ataxia-27 (SCAR27) in a Chinese family. Brain 2020 Jun 1;143(6):e50. doi: 10.1093/brain/awaa121.

Hai-Lin Dong, Qiao Wei, Jia-Qi Li, Hong-Fu Li, Ge Bai, Huan Ma, Zhi-Ying Wu*. Genetic spectrum of MCM3AP and its relationship with phenotype of Charcot-Marie-Tooth disease. J Peripher Nerv Syst. 2020 Jun;25(2):107-111. doi: 10.1111/jns.12377. 

Juan-Juan Xie, Wang Ni, Qiao Wei, Huan Ma, Ge Bai, Ying Shen, Zhi-Ying Wu*. New clinical characteristics and novel pathogenic variants of patients with hereditary leukodystrophies. CNS Neuroscience & Therapeutics. 2019 Dec 29. doi: 10.1111/cns.13284.

Cong-Xin Chen, Hai-Lin Dong, Qiao Wei, Li-Xi Li, Hao Yu, Jia-Qi Li, Gong-Lu Liu, Hong-Fu Li, Ge Bai, Huan Ma, Zhi-Ying Wu*. Genetic spectrum and clinical profiles in a southeast Chinese cohort of Charcot-Marie-Tooth disease. Clinical Genetics. 2019 96(5):439-448.

Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Na Wei, Xu-Qiao Chen, Ze Liu, Chengbiao Wu, Robert W. Burgess, Samuel L. Pfaff, Ge Bai, Xiang-Lei Yang*. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nature communications. 2018 9(1):1007. doi: 10.1038/s41467-018-03461-z.

David Blocquel, Sheng Li, Na Wei, Herwin Daub, Mathew Sajish, Maria-Luise Erfurth, Grace Kooi, Jiadong Zhou, Ge Bai, Paul Schimmel, Albena Jordanova and Xiang-Lei Yang*. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Nucleic Acids Research. 2017 45(13): 8091–8104.

Neal Amin, Ge Bai, Jason Klug, Dario Bonanomi, Mathew Pankratz, Wesley D. Gifford, Christopher A. Hinckley, Shawn P. Driscoll, Bertha Dominguez, Kuo-Fen Lee, Xin Jin, and Samuel L. Pfaff*. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science.2015 350(6267):1525-9.

Weiwei He#, Ge Bai#, Huihao Zhou, Nicholas M. White, Jeni Lauer, Huaqing Liu, Yi Shi, Calin Dan Dumitru, Karen Lettieri, Veronica Shubayev, Patrick Griffin, Robert W. Burgess, Samuel L. Pfaff* and Xiang-Lei Yang*. CMT2D Neuropathy is Linked to the Neomorphic Binding Activity of Glycyl-tRNA Synthetase. Nature.2015 526:710-714. (# Co-first author) 

Dario Bonanomi, Onanong Chivatakarn, Ge Bai, Karen Lettieri, Houari Abdesselem, Till Marquardt, Brian A. Pierchala and Samuel L. Pfaff. Ret is a Multifunctional Co-receptor that Integrates Diffusible- and Contact-axon Guidance Signals. Cell. 2012 148(3): 568-582.

Ge Bai, Samuel L. Pfaff. Protease Regulation: The Yin and Yang of Neural Development and Disease. Neuron.2011 72(1): 9-21.(Featured Article)

Ge Bai, Onanong Chivatakarn, Dario Bonanomi, Karen Lettieri, Laura Franco, Caihong Xia, Elke Stein, Le Ma, Joseph W. Lewcock, Samuel L. Pfaff.. Presenilin-dependent Receptor Processing is Required for Axon Guidance. Cell. 2011 144(1): 106-118. (Cover Article)

Zhihui Xie, Yongfeng Chen, Zhenfei Li, Ge Bai, Yue Zhu, Ye-Guang Chen, Francois Guillemot, Lin Li and Naihe Jing. Smad6 Inhibits Wnt/-catenin Pathway by Recruiting CtBP to Promote Neuronal Differentiation. The Proceedings of the National Academy of Sciences.2011 108(29): 12119-12124.

Nengyin Sheng, Zhihui Xie, Chen Wang, Ge Bai, Kejing Zhang, Qingqing Zhu, Francois Guillemot, Ye-Guang Chen, Anning Lin, and Naihe Jing. RA Represses BMP Signaling through Promoting Degradation of Phosphorylated Smad1. The Proceedings of the National Academy of Sciences.2010 107(44): 18886-18891.

Ge Bai, Nengyin Sheng, Zhihui Xie, Wei Bian, Yoshifumi Yokota, Robert Benezra Ryoichiro Kageyama, Francois Guillemot and Naihe Jing. Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1. Developmental Cell.2007 13: 283-297. (Highlighted by Nature China)

Ge Bai, Ke Tang and Naihe Jing. Cross-talk between Wnts and Other Signaling Networks in Vertebrate Development. Chemistry of Life.2002 22(4): 304–307. (in Chinese)

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