Research Summary

Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. A thorough comparative analysis of 282 cancer samples with 47 normal samples from GEO datasets resulted in the observation that that the level of ACADS was significantly downregulated in HCC. It was noted that ACADS was involved in the proliferation and metastasis of HCC. The TCGA database was then employed to identify tumor tissue samples which showed higher methylation levels at cg01535453, cg08618068, and cg10174836 (which are the target sites of the ACADS CpG islands) as compared with normal liver tissue samples. All these findings indicated that ACADS might be a novel methylation biomarker associated with HCC. 2010-2020

TLR plays an important role in innate immunity and its role in chronic hepatitis has received increased attention. To explore the relationship between the TLR and chronic HBV infection, we investigated the expression of TLR and related genes in hepatocytes and the interface of virus proteins of HBV such HBcAg, HBsAg in TLR signaling. The project "Regulation of IFN-beta expression of hepatocytes induced by virus PAMPs and its mechanism (Y207534)" was funded by natural science foundation of Zhejiang province.  2003.10-2010  

As a Post. D, Dr. Chen did research in IFN signaling and its function in tumor. His team found that IFN play an important role in anti-tumor by increasing the expression of p53 protein to inhibit the growth of tumour cells. 2001.10-2003.09