Chen Xiao, M.D., Ph.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor

Clinical / Research Interests

Tendon and ligament differentiation and regeneration biology;

Musculoskeletal tissue engineering;

Mesenchymal stem cells aging, differentiation and regeneration biology.

Professional Highlights

Zhejiang Provincial Natural Science Academic Award, First Prize, 2019

Science and Technology Award of Biomaterials Society, Second Prize, 2019

Excellence in Cartilage Research, 15th International Cartilage Regeneration & Joint Preservation Society (ICRS) World Congress, 2019

National Natural Science Awards, Ministry of Education of China, Second Prize, 2014

Science and Technology Progress Awards, Ministry of Education of China, First Prize, 2012

Savio L-Y Woo Young Researcher Award, 10th International Symposium on Ligaments and Tendons (ISL&T-X), 2010

Young Investigator Award in the 13 the International Conference on Biomedical Engineering, Singapore, 2008

Professional Appointments

Chair, the 1st Symposium on Tendon/Ligament Regenerative Medicine, 2020

Standing Committee, the 2rd Committee of Basic Research Professional Committee of China, Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT), 2019-Present

Committee Member, Sports Medicine Professional Committee, Chinese Research Hospital Association, 2019-Present

General Secretary, Youth Work group of Tissue Engineering and Regenerative Medicine Sub-Association, Chinese Society of Biomedical Engineering, 2019-Present

Vice Chair, Program Committee, the 17th International Symposium on Ligaments & Tendons Conference, 2018

Deputy Group Leader, Youth Committee of Transformation and Innovation Group, the 11th Committee of Chinese Society of Orthopedics, 2017-Present

Deputy Group Leader, Basics Group, 11th Youth Committee of Chinese Society of Orthopedics, 2018-Present

Youth Committee Member, International Chinese Musculoskeletal Research Society, 2017-Present

Youth Committee Member, Tissue Engineering and Regenerative Medicine Sub-Associations Council, Chinese Society of Biomedical Engineering, 2014-Present

Member, Stem Cells and Organ Transplantation Professional Committee, Chinese Society of Organ Transplantation Surgeons, Chinese Medical Doctor Association, 2017-Present

Editorial Board, the Annals of Translational Medicine, 2014-2017 

Education Experience

Research Summary

1. Found a new tendon differentiation model and recovered new mechanism of tendon differentiation: Prof. Chen's team was the first to report to induce the pluripotent stem cells into tenocytes, proved that embryonic cells are more suitable for tendon tissue engineering, established in vitro scaffold-free tendon tissue engineering model, and found that transcription factor and mechanical stress have synergetic function on tendon differentiation.

2. Fabricated functional tendon scaffold: Prof. Chens' team used knitted silk scaffold with proper mechanical strength and internal spaces for tissue growth. For this innovation, Prof. Chen was awarded the second prize of the Natural Science Award by the Ministry of Education of China.

3. Found a new NES+ tendon stem cells subpopulation.


Qin T (#), Fan CM (#), Wang TZ (#), Sun H, Zhao YY, Yan RJ, Yang L, Shen WL, Lin JX, Bunpetch V, Cucchiarini M, Clement ND, Mason CE, Nakamura N, Bhonde R, Yin Z (*), Chen X (*). Single-Cell RNA-Seq Reveals Novel Mitochondria-related Musculoskeletal Cell Populations during Adult Axolotl Limb Regeneration Process. Cell Death and Differentiation, 2020, in press. 

Yin Z (#), Lin JX (#), Yan RJ (#), Liu RC, Liu MF, Zhou B, Zhou WY, An CR, Chen YW, Hu YJ, Fan CM, Zhao K, Wu BB, Zou XH, Zhang J, El-Hashash AH, Chen X (*), Ouyang HW (*). Atlas of Musculoskeletal Stem Cells with The Soft and Hard Tissue Differentiation Architecture, Advanced Science, 2020, in press. 

Chen YW (#), Shen WL (#), Tang CQ, Huang JY, Fan CM, Yin Z, Hu YJ, Chen WS, Ouyang HW, Zhou YT (*), Mao ZW (*), Chen X (*). Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification. Science Advances, 2020.6(18): eaay9526.

Zhang H (#), Liu MF, Liu RC, Shen WL, Yin Z, Chen X (*). Physical microenvironment-based inducible scaffold for stem cell tenogenesis and tendon regeneration. Tissue Engineering Part B Reviews, 2018: ten.TEB.2018.0018. 

Zhang C (#), Zhang E, Yang L, Tu W, Lin J, Yuan C, Bunpetch V, Chen X (*), Ouyang HW (*). Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair. Biomaterials. 2018. 172: 66-82. 

Zhang YJ (#), Chen X (#), Li G, Chan KM, Heng BC, Yin Z (*), Ouyang HW (*). Concise review: stem cell fate guided by bioactive molecules for tendon regeneration. Stem Cells Translation Medicine, 2018, 7(5): 404-414.

Cong XX (#), Rao XS (#), Lin JX (#), Liu XC, Zhang GA, Gao XK, He MY, Shen WL, Fan W, Pioletti D, Zheng LL, Liu HH, Yin Z, Low BC, Schweitzer R, Ouyang H, Chen X (*), Zhou YT (*). Activation of AKT-mTOR signaling directs tenogenesis of mesenchymal stem cells. Stem Cells. 2018. 36(4): 527-539.

Zhang C (#), Wang XL (#), Zhang E, Yang L, Yuan HH, Tu WJ, Zhang HL, Yin Z, Shen WL, Chen X (*), Zhang YZ (*) and Ouyang HW (*). An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. Acta Biomaterialia, 2018, 66: 141-156.

Chen J (#), Zhang E (#), Zhang W, Liu Z, Lu P, Zhu T, Yin Z, Backman LJ, Liu H, Chen X (*), Ouyang HW (*). Fos promotes early stage teno-lineage differentiation of tendon stem/progenitor cells in tendon. Stem Cells Translational Medicine. 2017. 6(11): 2009-2019. 

Liu HH (#), Yang L (#), Zhang E, Zhang R, Cai DD, Zhu SA, Ran JS, Bunpetch V, Cai YZ, Heng BC, Hu YJ, Dai XS, Chen X (*), Ouyang HW (*). Biomimetic tendon extracellular matrix composite gradient scaffold enhances ligament-to-bone junction reconstruction. Acta Biomaterialia. 2017. 56: 129-140. 

Yin Z (#), Hu JJ (#), Yang L, Zheng ZF, An CR, Wu BB, Zhang C, Shen WL, Liu HH, Chen JL, Heng BC, Guo GJ, Chen X (*), Ouyang HW (*). Single-cell analysis reveals a nestin+tendon stem/progenitor cell population with strong tenogenic potentiality. Science Advances, 2016, 2(11): e1600874-e1600874. 

Hu JJ (#), Yin Z (#), Shen WL, Xie YB, Zhu T, Lu P, Cai YZ, Kong MJ, Heng BC, Zhou YT, Chen WS, Chen X (*), Ouyang HW. Manipulating stem cells to treat calcification pharmacological regulation of in-situ tissue stem cells differentiation for soft tissue calcification treatment. Stem Cells 2016,34: 1083–1096.

Chen X (#), Gu S (#), Chen BF, Shen WL, Yin Z, Xu GW, Hu JJ, Zhu T, Li G, Wan C, Ouyang HW, Lee TL (*), Chan WY (*). Nanoparticle delivery of stable miR-199a-5p agomir improve the osteogenesis of Human Mesenchymal stem cells via the HIF1a pathway. Biomaterials, 2015, 53:239-250. 

Yin Z (#), Chen X (#), Song HX, Hu JJ, Tang QM, Zhu T, Shen WL, Chen JL, Liu HH, Heng BC, Ouyang Hongwei (*). Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation. Biomaterials, 2015, 44: 173-185. 

Liu HH (#), Zhang Ca, Zhu SA, Lu P, Zhu T, Gong XN, Hu JJ, Yin Z, Chen X (*), Ouyang HW (*). Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway. Stem Cells, 2015,33(2):443-55. 

Chen X (#), Yin Z (#), Chen JL, Liu HH, Shen WL, Fang Z, Zhu T, Ji JF, Ouyang HW, Zou XH (*). Scleraxis-overexpressed human embryonic stem cell-derived mesenchymal stem cells for tendon tissue engineering with knitted silk-collagen scaffold. Tissue Engineering Part A, 2014, 20(11-12):1583-92. 

Fang Z (#), Zhu T, Shen WL, Tang QM, Chen JL, Yin Z, Ji JF, Heng BC, Ouyang HW (*), Chen X (*). Transplantation of fetal instead of adult fibroblasts reduces the probability of ectopic ossification during tendon repair. Tissue engineering. Part A, 2014, 20(13-14):1815-26.

Tang QM (#), Chen JL, Shen WL, Yin Z, Liu HH, Fang Z, Heng BC, Ouyang HW (*), Chen X (*). Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration. Sci Rep, 2014,4:5515.

Chen X (#), Yin Z (#), Chen JL, Shen WL, Liu HH, Tang QM, Fang Z, Lu LR, Ji J (*), Ouyang HW (*). Mechanical force and scleraxis synergistically promote the commitment of human embryonic stem cells to tenocytes for functional tendon regeneration. Sci Rep, 2012, 2, 977. 

Chen X (#), Song XH, Yin Z, Zou XH, Wang LL, Hu H, Cao T, Zheng M, and Ouyang HW (*), Stepwise Differentiation of Human Embryonic Stem Cells Promotes Tendon Regeneration by Secreting Fetal Tendon Matrix and Differentiation Factors. Stem Cells, 2009. 27(6): 1276-1287. 

Chen X (#), Qi YY, Wang LL, Yin Z, Yin GL, Zou XH, and Ouyang HW (*), Ligament regeneration using a knitted silk scaffold combined with collagen matrix. Biomaterials, 2008. 29(27): 3683-3692. 

Liu HH (#),Zhu SA (#),Zhang C, Lu P, Hu JJ, Yin Z, Ma Y, Chen X (*), Ouyang HW (*), Crucial transcription factors in tendon development and differentiation: their potential for tendon regeneration. Cell and Tissue Research, 2014, 356(2):287-298. 

Shen WL (#), Chen X (#), Hu YJ, Yin Z, Zhu T, Hu JJ, Chen JL, Zheng ZF, Zhang W, Ran JS, Heng BC, Ji JF, Chen WS (*), Ouyang HW (*). Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention. Biomaterials, 2014,35(28): 8154-63. 

Yin Z (#), Chen X (#), Zhu T, Hu JJ, Song HX, Jiang LY, Heng BC, Ji JF, Ouyang HW (*), The effect of decellularized matrices on human tendon stem/progenitor cells differentiation and tendon repair. Acta Biomaterialia, 2013. 2013 Dec; 9(12): 9317-29. 

Yin Z (#), Chen X (#), Chen JL, Shen WL, Nguyen MH, Gao L, Ouyang HW (*), The regulation of tendon stem cell differentiation by the alignment of nanofibers.              Biomaterials, 2010. 31(8): 2163-2175.

Yin Z (#), Chen X (#), Chen JL, and Ouyang HW (*), Stem cells for tendon tissue engineering and regeneration. Expert Opinion on Biological Therapy, 2010. 10(5): 689-700.

Chen X (#), Zou XH, Guo LY, Ouyang HW, Tendon tissue engineering with mesenchymal stem cells and biografts: An option for large tendon defects? Frontiers in Bioscience, 2009. S1(1): 23-32. 

Current Program

Targeting delivery of rapamycin to injured collagen prevents the heterotopic ossification of tendon. Funding Source: National Natural Science Foundation of China.

Basic research based on the biological effect bionic assembly composite tissue of new nanoclusters. Funding Source: Ministry of Science and Technology of the People's Republic of China.

Three-dimensional microenvironment maintains TSPCs phenotype and tenogenesis through epigenetic regulation. Funding Source: National Natural Science Foundation of China.

In vitro automated, large-scale stem cell cultivation and expansion system. Funding Source: National Natural Science Foundation of China.

Find People

Search by Family Name

Find A Department

Search by Departments