Chen Xuequn, Ph.D.


Medical School:College of Life Sciences, Zhejiang University, China

Academic Rank:Professor

Clinical / Research Interests


Physiology and neuroendocrinology;

Molecular mechanism of neuro-endocrine-immune network;

CRF and its receptors family under hypoxia stress;

Molecular development and evolution of neuroendocrinological axis.

Professional Highlights

Nature and Science Award, Ministry of Education of China, Second Prize, 2006

Professional Appointments

Chair, Endocrine and Metabolism Professional Committee, Chinese Association for Physiological Sciences

Vice Chair, Comparative Physiology Professional Committee, Chinese Association for Physiological Sciences 

Member, Applied Physiology Committee of Chinese Association for Physiological Sciences 

Member, Respiration and Hypoxia in Chinese Association of Pathophysiology

Member, Comparative Endocrine Committee, China Zoological Society 

Representative Person, International Neuroendocrine Federation

Editorial Board Member, Journal of Neuroendocrinology

Education Experience

Research Summary

Dr. Chen focuses on the mechanism of neurobiology, physiology and neuroendocrinology under stress, currently investigates the molecular mechanism of neuro-endocrine-immune network, especially CRF and its receptors family under hypoxia stress, and molecular development and evolution of neuroendocrinological axis, and understands the response and adaptation mechanism of the high altitude hypoxia environment.  


Khan S, Lu X, Huang Q, Tang J, Weng J, Yang Z, Lv M, Xu X, Xia F, Zhang M, Li Y, Liu S, Leng G, Spitzer N, Du J, Chen X*. IGFBP2 plays an essential role in cognitive development during early life. Adv Sci (Weinh). 2019,14;6(23):1901152.

Li Y, Zhang MC, Xu XK, Zhao Y, Chatoo M, Zhu T, Deng H, Nevo E, Du J, Chen X*. Functional diversity of p53 in human and wild animals. Front Endocrinol (Lausanne). 2019; 10:152.

Chatoo M, Li Y, Ma Z, Coote J, Du J*, Chen X*. Involvement of corticotropin-releasing factor and receptors in immune cells in irritable bowel syndrome. Front Endocrinol (Lausanne). 2018; 9:21.

Shi YJ, Ma ZQ, Tang JW, Zhao Y, Wang X, Liu Q, Wang PP, John C, Chen XQ, Du JZ. The integration of multiple signaling pathways provides for bidirectional control of CRHR1 gene transcription in rat pituitary cell during hypoxia. Mol Cell Endocrinol 454:12-22. 

Song TT, Bi YH, Gao YQ, Huang R, Hao K, Xu G, Tang JW, Ma ZQ, Kong FP, Coote JH, Chen XQ. Du JZ Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia. J Neuroinflammation 13:63. 

Zhao Y, Tang JW, Yang Z, Cao YB, Ren JL, Ben-Abu Y, Li K, Chen XQ*, Du JZ*, Nevo E*. Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax. Proc Natl Acad Sci U S A 2016;113(8):2146-51.

Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM, Lightman SL, Chen XQ, Du JZ. Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia. Diabetes 64:785-795. 

Chen SJ, Yang JF, Kong FP, Ren JL, Hao K, Li M, Yuan Y, Chen XC, Yu RS, Li JF, Leng G, Chen XQ, Du JZ. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema. Proc Natl Acad Sci USA 111:13199-13204. 

Zhao Y, Ren JL, Wang MY, Zhang ST, Liu Y, Li M, Cao YB, Zu HY, Chen XC, Wu CI, Nevo E*, Chen XQ*, Du JZ*. Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau. Proc Natl Acad Sci U S A 2013;110(51):20639-44.

Zhang ST, Zhao Y, Hu XF, Chen XQ*, Du JZ*. Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau's root vole Microtus oeconomus. Molecular and Cellular Endocrinology 2013;376: 33-42.

Zhao Y, Wang MY, Hao K, Chen XQ*, Du JZ*. CRHR1 mediates p53 transcription induced by high altitude hypoxia through ERK 1/2 signaling in rat hepatic cells. Peptides 2013;44:8-14.

Xi Wang, Fan-Sen Meng, Zong-Yun Liu, Jun-Ming Fan, Ke Hao, Xue-Qun Chen* and Ji-Zeng Du*. Gestational Hypoxia Induces Sex-differential Methylation of Crhr1 linked to Anxiety-like Behavior. Molecular Neurobiology 2013; 48:544-555. 

Current Program

Mechanism of CRF and CRFR response and adaptation in HPA axis function under high altitude hypoxia. Funding Source: General Program, National Natural Science Foundation of China.

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