Feng Youjun, Ph.D.

Department:General ICU

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor

Clinical / Research Interests

Medical microbiology

Emerging and re-emerging infectious diseases

Professional Highlights

National Science and Technology Award, Second Prize

Professional Appointments

Associate Editor, Virulence, 2014-present 

Education Experience

Research Summary

Dr. Feng's laboratory focuses on fatty acid metabolism and its contribution to antibiotic resistance in bacterial pathogens.

Dr. Feng defined that structural remodeling of the FAS II-derived lipid A acts as biochemical basis for colistin resistance by plasmid-borne MCR-like genes. 


Ullah S#, Ji K#, Li J, Xu Y, Jiang C, Zhang H, Huang M, Feng Y*, Characterization of NMCR-2, a new non-mobile colistin resistance enzyme: Implications for an MCR-8 ancestor. Environ Microbiol, 2020, July 20. doi: 10.1111/1462-2920.15171. 

Zhang H, Srinivas S, Xu Y, Wei W, Feng Y*, Genetic and biochemical mechanisms for bacterial lipid A modifiers associated with polymyxin resistance. Trends Biochem Sci, 2019 Nov; 44(11):973-988. 

Gao R, Wei W, Hassan BH, Li J, Deng J, Feng Y*, A single regulator NrtR maintains bacterial NAD+ homeostasis via its acetylation. eLife, 2019 Oct 9; 8: e51603. 

Wei W#, Guan H#, Zhu T#, Zhang S#, Fan C, Ouyang S*, Feng Y*, Molecular basis of BioJ, a unique gatekeeper in bacterial biotin synthesis. iScience, 2019 Aug 22; 19: 796-808.

Xu Y, Liu L, Sun J, Feng Y*, Limited distribution and mechanism for the TetX4 tigecycline resistance enzyme. Sci Bull, 2019, 64(20): 1478-1481. 

Zhang H#, Wei W#, Huang M, Umar Z, Feng Y*, Definition of a family of nonmobile colistin resistance (NMCR-1) determinants suggests aquatic reservoirs for MCR-4. Adv Sci, 2019, 6(11): 201900038. 

Zhang H#, Zong Z#*, Lei S#, Srinivas S, Sun J, Feng Y, Huang M, Feng Y*, A genomic, evolutionary, and mechanistic study of MCR-5 action suggests functional unification across the MCR family of colistin resistance. Adv Sci, 2019, 6(11): 201900034. 

Wang Q, Hassan BH, Lou N, Merritt J, Feng Y*, Functional definition of NrtR, a remnant regulator of NAD+ homeostasis in the zoonotic pathogen, Streptococcus suis. FASEB J. 2019 May; 33(5): 6055-6068. 

Zhang H#, Hou M#, Xu Y#, Srinivas S, Huang M, Liu L, Feng Y*, Action and mechanism of the colistin resistance enzyme MCR-4. Commun Biol. 2019 Jan 25; 2: 36. 

Xu Y#, Zhong L#, Srinivas S#, Sun J#, Paterson DL, Lei S, Lin J, Xin Li, Tang Z, Feng S, Shen C, Tian GB*, Feng Y*, Spread of MCR-3 colistin resistance in China: An epidemiological, genomic and mechanistic study. EBioMedicine, 2018, 34: 139-157. 

Wei W#, Zhang Y#, Gao R#, Li J, Xu Y, Wang S, Ji Q*, Feng Y*, Crystal structure and acetylation of BioQ suggests a novel regulatory switch for biotin biosynthesis in Mycobacterium smegmatis. Mol Microbiol, 2018 Sep; 109(5): 642-662.

Wei W#, Srinivas S#, Lin J#, Tang Z#, Wang SH, Ullah S, Kota VG, Feng Y*, Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis. PLoS Genet, 2018, May 14;14(5): e1007389. 

Xu Y#, Wei W#, Lei S#, Lin J, Srinivas S, Feng Y*, An evolutionarily-conserved mechanism for intrinsic and transferable polymyxin resistance. mBio, 2018 Apr 10; 9 (2): e02317-17. 

Sun J#, Zhang H#, Liu YH*, Feng Y*, Towards understanding MCR-like colistin resistance. Trends Microbiol, 2018 Sep; 26(9): 794-808.

Xu Y#, Lin J#, Cui T#, Srinivas S, Feng Y*, Mechanistic insights into transferable polymyxin resistance among gut bacteria. J Biol Chem, 2018 Mar 23; 293 (12): 4350-4365.

Wang Q#, Sun J#, Li J#, Ding Y, Li XP, Lin J, Hassan B, Feng Y*. Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs. Microbiome. 2017, Jul 6; 5(1):70. 

Sun J#, Xu Y#, Gao R#, Lin J, Wei W, Srinivas S, Li D, Yang RS, Li XP, Liao XP, Liu YH*, Feng Y*. Deciphering MCR-2 colistin resistance. mBio. 2017 May 9; 8(3): e00625-17.

Wang Q, Sun J, Ding Y, Li XP, Liu YH, Feng Y*. Genomic insights into mcr-1-positive plasmids carried by the colistin-resistant Escherichia coli from the inpatients. AAC. 2017 Jun 27; 61(7): e00361-17. 

Gao R#, Hu Y#, Li Z#, Sun J#, Wang Q, Lin J, Ye H, Liu F, Srinivas S, Li D, Zhu B, Liu Y, Tian GB, Feng Y*. Dissemination and mechanism for the MCR-1 colistin resistance. PLoS Pathog, 2016, 12 (11): e1005957.

Shi X#, Ye H#, Wang J, Li Z, Wang J, Chen B, Wen R, Hu Q, Feng Y*, Loss of 89K pathogenicity island in epidemic Streptococcus suis, China. Emerg Infect Dis 2016 Jun; 22(6):1126-1127.

Ye H#, Li Y#, Li Z, Gao R, Zhang H, Wen R, Gao GF, Hu Q, Feng Y*, Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota. mBio, 2016 Apr 5; 7(2): e00177-16.  

Zhang H, Seward C, Wu Z, Ye H, Feng Y*, Genomic insights into the ESBL and MCR-1-producing ST648 Escherichia coli with multi-drug resistance. Sci Bull 2016, 61: 875-878.

Gao R#, Lin J#, Zhang H, Feng Y*, Transcriptional repression of the VC2105 by the Vibrio FadR suggests a new auxilliary member of fad regulon. Appl Environ Microbiol. 2016 Mar 4. 82(9): 2819-2832. 

Zhang H, Zheng B, Gao R, Feng Y*, Binding of Shewanella FadR to the fabA fatty acid biosynthetic gene: Implications for contraction of the fad regulon. Protein & Cell, 2015, 6(9): 667-679.

Tang Q, Li X, Zou T, Zhang H, Wang Y, Gao R, Li Z, He J*, Feng Y*. Mycobacterium smegmatis BioQ defines a new regulatory network for biotin metabolism. Mol Microbiol, 2014, 94(5): 1006-1020. 

Zhang Y, Gao R, Ye H, Wang Q, Feng Y*, A new glimpse of FadR-DNA crosstalk revealed by deep dissection of the E. coli FadR regulatory protein. Protein & Cell, 2014, 5(12): 928-39. 

Current Program

The MCR Family: New Mechanism for Colistin Resistance. Funding Source: Key Program, National Natural Science Foundation of China.

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