Medical School：Institute of Neuroscience, Chinese Academy of Sciences, China
Establishment of non-human primate models of autism spectral disorders and mood disorders such as major depress disorders and bipolar disorders, brain mechanisms underlying ASD and mood disorders, noninvasive blood vessel imaging and functional studies.
W. Barry Wood, Jr. Research Award, Johns Hopkins University School of Medicine
Committee Member, Chinese Biophysical Society
Dr. Gao focused on brain mechanisms underlying sound processing, vocal communications as well as related human mental diseases.
Her studies are carried out in awake marmoset monkeys, a social non-human primate model with a stronger homology to the human brain than rodents. She mainly performs intracellular recording, single or multi-electrode extracellular recordings from the auditory cortex and subcortical regions in awake head-fixed marmosets.
She is also working on establishing marmoset models of ASD, MDD/BD. By using various behavioral test paradigms related to ASD, MMD/BD, she can evaluate the clinical changes of the gene-mutation marmosets.
Moreover, she can further examine the neural circuit mechanisms underlying ASD, MDD/BD and find some promising biomarkers.
Lixia Gao* and Xiaoqin Wang, Intracellular neuronal recording in awake nonhuman primates. Nature Protocol, 2020 Oct.15:3615–3631.
Lixia Gao*, Yuanqing Zhang, Xinjian Li, Jufang He, Enhancement of Neuronal Activity in the Auditory Thalamus after Simulated Slow-Wave Oscillation, Neuroscience Bulletin, 2020 Jul; 36(7):806-810.
Lixia Gao* and Xiaoqin Wang, Subthreshold Activity Underlying the Diversity and Selectivity of the Primary Auditory Cortex Studied by Intracellular Recordings in Awake Marmosets, Cerebral Cortex, 2019 Mar 1; 29(3):994-1005, *First and corresponding authors
Lixia Gao*, Xinjian Li, Wenwei Yang, Xinde Sun, Modulation of the azimuth tuning plasticity in rat primary auditory cortex by medial prefrontal cortex, Neuroscience, 2017 Apr 7;347:36-47, *First and corresponding authors
Lixia Gao, Kevin Kostlan, Yunyan Wang and Xiaoqin Wang , Distinct Subthreshold Mechanisms Underlying Rate-Coding Principles in Primate Auditory Cortex. Neuron, 91 (4): 905-919, 2016, Cover paper.
Lixia Gao, Xiankai Meng, Yang Dan, Muming Poo, Jufang He, Xiaohui Zhang, Entrainment of slow oscillations of auditory thalamic neurons by repetitive sound stimuli J. Neurosci. 29(18): 6023-6031, 2009.
Lixia Gao, Fei Gao, Xinde Sun, Effects of lead on learning and memory. Biology Teaching, 2004 (6), 2004.
Wenwei Yang, Lixia Gao, Xinde Sun, Receptive field plasticity of neurons in rat auditory cortex. Chinese Science Bulletin 49 (13): 1364-1369, 2004.
Modulation of thalamic neural responses to time-vary stimuli by the auditory cortex of awake marmosets. Funding Source: National Natural Science Foundation of China.
The establishment of viral-based gene edited non-human primate models for autism spectrum disorders and neural circuity study. Funding Source: National Natural Science Foundation of China.
Population coding underlying periodic sound processing in auditory cortical of awake marmoset. Funding Source: National Natural Science Foundation of China.
Epigenetic perspectives of safety in assisted reproductive technologies. Funding Source: National Key Research and Development Program of China.
The establishment of viral-based gene edited non-human primate models for major depressive disorders and neural circuity study. Funding Source: Zhejiang University Special Fund for Basic Scientific Research.