Gao Zhihua, Ph.D


Medical School:University of Alberta, Canada

Academic Rank:Professor

Clinical / Research Interests

The role of neuroimmune and neuroendocrine regulation in brain development and brain pathology

Professional Highlights

Professional Appointments

Education Experience

Research Summary


Zhang B, Qiu L, Xiao W, Ni H, Chen L, Wang F, Mai W, Wu J, Bao A, Hu H, Gong H, Duan S, Li A*, Gao Z*. Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain. Neuron, 2020 Nov 18; doi: 10.1016/j.neuron.2020.10.032. 

Hu Y, Mai W, Chen L, Cao K, Zhang B, Zhang Z, Liu Y, Lou H, Duan S*, Gao Z*. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia. 2020 May; 68(5):1031-1045.

Li X, Qin L, Li Y, Yu H, Zhang Z, Tao C, Liu Y, Xue Y, Zhang X, Xu Z, Wang Y, Lou H, Tan Z, Saftig P, Chen Z, Xu T, Bi G, Duan S*, Gao Z*. Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Cell Rep. 2019 Jul 23; 28(4):1015-1028.e5. 

Meng F, Guo Z, Hu Y, Mai W, Zhang Z, Zhang B, Ge Q, Lou H, Chen JF, Duan S*, Gao Z*. CD73-derived adenosine controls microglia-mediated inflammation by modulating dopamine signaling. Brain. 2019 Mar 1;142 (3):700-718. 

Yang G,Chen L, Gao Z*,Wang Y*. Implication of microglia activation and CSF-1/CSF1-R pathway in lumbar disc degeneration-related back pain. Mol Pain. 2018 Jan-Dec;14:1744806918811238. doi:10.1177/1744806918811238. 

Zhang B, Wang W, Zhang Z, Hu Y, Meng F, Wang F, Lou H, Zhu L, Godbout R, Duan S, Gao Z*. Alternative splicing of Disabled-1 controls multipolar-to-bipolar transition of migrating neurons in the neocortex. Cereb Cortex, 2018, 28 (10): 3457-3467. 

Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z*, Duan SM*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. J Neurosci. 2015, 35 (6):2674-88.

Current Program

The role of Disabled-1 Alternative splicing in Reelin signaling and neuronal migration. Funding Source: Natural Science Foundation of China.

Molecular characterization of the chemotactic switch of activated microglia in response to ATP. Funding Source: Natural Science Foundation of China.

The role and regulatory mechanisms of glucose metabolic reprogramming in sustained microglial activation. Funding Source: Natural Science Foundation of China.

The function of vesicle protein machinery in neural development. Funding Source: National Key Research and Development Program.

Regulator mechanisms and replacement roles of human oligodendrocyte precursors transplantation in treating prenatal white matter injury. Funding Source: National Key Research and Development Program.

The role of hexokinase 2-mediated glucose metabolism in microglia development and functional plasticity. Funding Source: Natural Science Foundation of China.

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