Medical School：Zhejiang University School of Medicine, China
The role of histamine receptors in brain disorders and drug targets studies; and the modulation of synapses by microglia.
Natural Science Award of Ministry of Education, China, First Prize, 2018
Natural Science Award of Zhejiang Province, First Prize, 2015
Committee Member, Neuropsychopharmacology Group, Chinese Pharmacological Society
Committee Nember, Biochemistry and Molecular Pharmacology Group, Chinese Pharmacological Society
Vice Chair, Zhejiang Pharmacology Society
Editorial Committee Member, Neuroscience Bulletin
Dr. Hu focused on the study of the role of histamine receptors in brain disorders by employing Cre-Loxp system and found that histamine receptors regulated the autophagy in neurons and glutamate metabolism in astrocytes at the early phase of ischemic brain injury; while regulated neurogenesis and remyelination at the late phase of brain injury. Besides, histamine receptors in different types of neuron play distinctive actions in the pathogenesis of schizophrenia.
Dr. Hu also found that microglia displaced synapses to modulate neurotransmission.
Lei Jiang#, Li Cheng#, Han Chen, Haibin Dai, Dadao An, Qianyi Ma, Yanrong Zheng, Xiangnan Zhang, Weiwei Hu*, Zhong Chen, Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury, J Exp Med. 2021 Jan 4;218(1):e20191365.
Yushan Wan#, Bo Feng#, Yi You#, Jie Yu, Cenglin Xu, Haibin Dai, Bruce D. Trapp, Peng Shi, Zhong Chen*, Weiwei Hu*, Microglial displacement of GABAergic synapses is a protective event during complex febrile seizure. Cell Rep. 2020 Nov 3;33(5):108346.
Mahmoud I Youssef, Yiting Zhou, Ibrahim H Eissa, Yanhui Wang, Jing Zhang, Lei Jiang, Weiwei Hu*, Jianhua Qi, Zhong Chen*. Tetradecyl 2,3-dihydroxybenzoate alleviates oligodendrocyte damage following chronic cerebral hypoperfusion through IGF-1 receptor. Neurochem Int. 2020 May 7;138:104749.
Liao, Ru-jia; Chen, Youchao; Cheng, Li; Fan, Lishi; Chen, Han; Wan, Yushan; You, Yi; Zheng, Yanrong; Jiang, Lei; Chen, Zhong; Zhang, Xiangnan*; Hu, Weiwei*, Histamine H1 receptors in neural stem cells are required for the promotion of neurogenesis conferred by H3 receptor antagonism following traumatic brain injury, Stem Cell Rep.2017,12(3): 532–544.
Shen Z#, Zheng Y#, Wu J#, Chen Y, Wu X, Zhou Y, Yuan Y, Lu S, Jiang L, Qin Z, Chen Z, Hu Weiwei*, Zhang X*. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy. 2017 Mar 4;13(3):473-485.
Bin Chen, Bo Feng, Yangshun Tang, Yi You, Yi Wang, Weiwei Hou, Weiwei Hu*, Zhong Chen*. Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window. Exp Neurol, 2016, 283:29-38.
Zhao YY, Yuan Y, Chen Y, Jiang L, Liao RJ, Wang L, Zhang XN, Ohtsu H, Hu WW*, Chen Z*. Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation. CNS Neurosci Ther. 2015 May;21(5):454-62.
Yan HJ#, Zhang XN#, Hu WW#(co-first), Ma J, Hou WW, Zhang XZ, Wang XF, Gao JQ, Shen Y, LV JX, Ohtsu H, Han F, Wang GH, Chen Z*. Histamine H3 receptors aggravate cerebral ischemic injury by histamine-independent mechanisms, Nat Commun, 2014 Feb 25;5:3334.
Hu WW#, Wang Z#, Zhang SS, Jiang L, Zhang J, Zhang X, Lei QF, Park HJ, Fang WJ, Chen Z*. Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces. Biomaterials. 2014 Aug;35(26):7386-97.
The role of histamine H2 receptors in glutamatergic neurons in schizophrenia and the underlying mechanism. Funding Source: National Natural Science Foundation of China.
The role of H2 receptor in white matter repair in neonatal hypoxic-ischemic encephalopathy. Funding Source: National Natural Science Foundation of China.
The effect of precision modulation of cortical glutamatergic neurons on the promotion of whiter matter repair following chronic cerebral ischemia. Funding Source: Natural Science Fund for Distinguished Young Scholars of Zhejiang Province.