Department：Neurology
Medical School：Taiwan Chiao Tung University, China
Academic Rank：Professor
Brain Machine Interface (BMI): Neural coding in integration of somatosensory and motor systems for adaptive BMI.
Neuromodulation: Development of neuromodulation therapies for neurological diseases, such as Parkinson’s disease, stroke, autism, and depression.
BioMEMS sensor: Development of multi-functional neuroprobe-microchips based on BioMEMS technology.
Distinguished Young Investigator of China Frontiers of Engineering, Chinese Academy of Engineering, 2019
Associate Editor, ACS Chemical Neuroscience, 2020–present
Editor Member, Frontiers in Neuroscience, 2020–present
Committee Member, Neuroimage Professional Committee, Zhejiang Society for Neuroscience, 2019-present
Committee Member, Neuropsychology Professional Committee, Chinese Society of Cognitive Science, 2019-present
Vice Chair, Neurology Precise Medicine Branch, Zhejiang Society for Mathematical Medicine, 2018-present
Committee Member, Basic and Clinical Neurology Branch, Chinese Neuroscience Society, 2016-present
Associate Editor, J Neuroscience & Neuroengineering, 2011–present
Developing and applying cutting-edge neuroengineering approaches to investigate brain function and to treat neurological diseases. Using Bio-Micro-Electro-Mechanical Systems (BioMEMS) and nano materials to develop several types of multichannel flexible neuroprobe for chronic recording and deep brain stimulation (DBS).
Developing a novel means for electrophysiological recording inside the MRI using multichannel flexible neuroprobe and applied simultaneous DBS-fMRI to explore the functional connectivity enhanced by DBS in the monkey model.
Development of a noninvasive neuromodulation technology, focused ultrasound (FUS) neuromodulation. FUS neuromodulation is an innovative technology that was used safely and effectively to produce excitatory and inhibitory neuromodulation with high spatial resolution, adjustable focus and capable of targeting deep brain areas. Currently, the field of neuromodulation using FUS is growing due to its potential clinical applications; however, the effects of FUS-evoked circuit modulation and long-term side effects need further investigation. A combination of FUS stimulation and imaging-guided method can improve the spatial accuracy and simultaneously characterize FUS effects on a whole-brain scale. Dr. Lai has designed, simulated and made a MR-compatible FUS transducer and build a MRI-guided targeted FUS technology in 7T MRI. They are using structural MRI to monitor the brain tissue damage for evaluating safety and functional MRI to map changes in the regional brain activity for evaluating the functional effects pre, during and post FUS. A challenging but unsolved problem in system neuroscience is the mechanisms underlying the emergence of receptive field (RF) properties in the primate primary somatosensory cortex (S1). The spatiotemporal RF of S1 has been characterized, but thalamocortical and intracortical circuits that underlie this processing is still unclear. With the lab-designed novel multi-digit tactile simulator and the novel MR-compatible flexible neuroprobe, our group is investigating the neural mechanisms of tactile motion integration in somatosensory cortex involved the direction, speed, multi-digit integration. Understanding the mechanisms of tactile senses would be indispensable to further apply in restore the senses of touch by electrically stimulating S1 for the adaptive brain-machine interface.
In summary, using bioMEMS sensor, ultra-high field MRI, electrophysiology and DBS- or FUS- neuromodulation technologies as major research tools, the goals of her lab are: 1) Brain-Machine Interface: Neural coding in integration of somatosensory and motor systems for adaptive BMI; 2) Neuromodulation: Development of neuromodulation (DBS and FUS) therapies for neurological diseases, such as Parkinson’s disease, stroke, epilepsy and autism; 3) BioMEMS sensor: Development of multi-functional neuroprobe-microchips based on BioMEMS technology.
Chen BW#, Yang SH#, Lo YC, Wang CF, Wang HL, Hsu CY, Kuo YT, Chen JC, Lin SH, Pan HC, Lee QW, Yu Xiao, Qu Boyi, Kuo CH, Chen YY*, Lai HY*. Enhancement of hippocampal spatial decoding using a dynamic q-learning method with a relative reward using theta phase precession, Int J Neural Syst, 2020, 30(9):2050048.
Yang SH, Chou C, Lo YC, Lai HY, et al. Inhibition of long-term variability in decoding forelimb trajectory using evolutionary neural networks with error-correction learning, Front Comput Neurosci, 2020, 14:22.
Li SJ, Lo YC, Lai HY, et al. Uncovering the modulatory interactions of brain networks in cognition with central thalamic deep brain stimulation using functional magnetic resonance imaging, Neurosci, 2020, 440:65-84.
Yue YM, Jiang YS, Shen T, Pu JL, Lai HY*, Zhang BR*. ALFF and ReHo mapping reveals different functional patterns in early-and late-onset Parkinson's disease, Front Neurosci, 2020, 14:141.
Shen T, Hu J, Jiang YS, Zhao S, Lin CX, Yin XZ, Yan YP, Pu JL, Lai HY*, Zhang BR*. Early-onset Parkinson’s disease caused by PLA2G6 compound heterozygous mutation, a case report and literature review, Front Neurol, 2019, 10:915.
Shen T, Pu JL, Lai HY, et al. Genetic analysis of ATP13A2, PLA2G6 and FBXO7 in a cohort of Chinese patients with early-onset Parkinson's disease, Sci Report, 2018, 19;8 (1):14028.
Shen T, Zhao S, Jiang YS, Pu JL, Lai HY, et al. Haplotype analysis on relationship of DNAJC6 gene with early-onset Parkinson’s disease risk in Chinese population. J Parkinson Dis, 2018, 9(1):1-12.
Chai WY, Chu PC, Tsai CH, Lin CY, Yang HW, Lai HY*, Liu HL*. Image-guided focused-ultrasound CNS molecular delivery: An implementation via dynamic contrast-enhanced magnetic-resonance imaging, Sci Report, 2018, 7;8(1):4151.
Lin SH, Lai HY, Yu-Chun Lo YC, et al. Decreased Power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson’s patients under controlled desflurane inhalation anaesthesia, Front Neurosci11, 2017.
Wang CF, Yang SH*, Lin SH*, Chen PC, Lo YC, Pan HC, Lai HY, et al. A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning, Brain Stimul, 2017, 10 (2017) 672-683.
Huang WC, Lo YC, Chu CY, Lai HY, Chen YY, Chen SY. Conductive nanogel-interfaced neural microelectrode arrays with electrically controlled in-situ delivery of manganese ions enabling high-resolution MEMRI for synchronous neural tracing with deep brain stimulation, Biomaterials, 2017, 122: 141-153.
Bandla A, Liao LD*, Chan SJ, Ling JM, Liu YH, Shih YY, Wong TH, Peter TH, Lai HY, King N, Chen YY, Ng WH, Thakor NV. Simultaneous functional photoacoustic microscopy and electrocorticography reveal the impact of rtPA on dynamic neurovascular functions after cerebral ischemia, J Cereb Blood F Met, 2017.
Yang SH, Chen YY, Lin SH, Liao LD, Lu HH, Wang CF, Chen PC, Lo YC, Phan TD, Chao HY, Lin HC, Lai HY*, Huang WC. A sliced inverse regression (SIR) Decoding the forelimb movement from neuronal spikes in the rat motor cortex, Front Neurosci, 2016, 9:556.
Lin HJ, Pan HC, Lin SH Lin, Lo YC, Shen E, Liao LD, Liao PH, Chen YW, Jaw FS, Chu KW, Lai HY*, Chen YY*. Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior,Front Neural Circuit, 2016, 9(87).
Liu TC, Chuang MC, Chu CY, Huang WC, Lai HY, et al. Implantable Graphene-based neural electrode interfaces for electrophysiology & neurochemistry in in-vivo Hyperacute Stroke Model, ACS Appl Mater Inter, 2015, 8(1):187-96.
Liu YH, Liao LD*, Tan SSH, Kwon KY, Ling JM, Bandla A, Tan ETW, Shih YY, Li W, Ng W, Lai HY, Chen YY, Thakor NV. Assessment of neurovascular dynamics during transient ischemic attack by the novel integration of micro-electrocorticography electrode array with functional photoacoustic microscopy, Neurobiol Dis, 2015, 82:455-465.
Lin SH, Chen SW, Lo YC, Lai HY, et al. Quantitative measurement of Parkinsonian gait from walking in monocular image sequences using a centroid tracking algorithm, Med Biol Eng Comput, 2015, 54:485-496.
Huang WC, Lai HY, Kuo LW, et al. Multifunctional 3D patternable drug-embedded nanocarrier-based interfaces to enhance signal recording and reduce neuron degeneration in chronic neural implantation, Adv Mater, 2015, 27(28): 4186-93.
Gong CS Alex, Lai HY*, Huang SH, Lo YC, Chen PY, Tu PH, Tang CY, Lin CC, Chen YY*. A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo, Sensors, 2015, 15(6): 12700-12719.
Chu PC, Liu HL, Lai HY, Lin, CY, Tsai HC*, Pei YC*. Neuromodulation accompanying focused ultrasound induced blood brain barrier opening, Sci Report, 2015, 5:15477.
Liao LD*, Liu YH, Lai HY, et al. Rescue of cortical neurovascular functions during the hyperacute phase of ischemia by peripheral sensory stimulation, Neurobiol Dis, 2015,75:53-63.
Lai HY, Albaugh DL, Kao YC, Younce JR, Shih YY*. Robust deep brain stimulation functional MRI procedures in rats and mice using an MR-compatible tungsten microwire electrode, Magn Reson Med, 2015, 73(3):1246-51.
Kao YC, Li WJ, Lai HY, Lin W, Shih YY*. Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia. Neurobiol Dis, 2014,71:131-139.
Lai HY, Younce JR, Albaugh DL, et al. Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus. NeuroImage, 2014, 84:11-18.
Shih YY*, Huang S, Chen YY, Lai HY, et al. Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation. J Cereb Blood F Met, 2014, 34:1483–1492.
Liao LD, Bandla A, Ling JM, Liu YH, Chen YY, King NK, Lai HY, Ng WH, Thakor NV* . Special section on the brain initiative: Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model. Neurophotonics, 2014, 1:011007.
Chuang MC, Lai HY, Ho JA, Chen YY*. Multifunctional microelectrode array (mMEA) chip for neural-electrical and neural-chemical interfaces: characterization of comb interdigitated electrode towards dopamine detection. Biosens Bioelectron, 2013, 41:602-607.
Huang HY, Hu SH, Hung SY, Chiang CS, Liu HL, Chiou TL, Lai HY, Chen YY*, Chen SY* . SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. J Control Release, 2013, 172:118-127.
Pei YC*, Chang TY, Lee TC, Saha S, Lai HY, Gomez-Ramirez M, Chou SW and Wong MK. Cross-modal sensory integration of visual-tactile motion information: instrument design and human psychophysics. Sensors, 2013, 13:7212-7223.
Liao LD, Tsytsarev V, Delgado-Martinez I, Li ML, Erzurumlu R, Lin YR, Vipin A, Lai HY, Chen YY, Thakor NV*. Neurovascular coupling: in vivo optical techniques for functional brain imaging. BioMed Eng OnLine, 2013, 12:38.
Shih YY*, Chen YY, Lai HY, Kao YC, Shyu BC, Duong TQ*. Ultra-high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex. NeuroImage, 2013, 73:113-120.
Lai HY, Liao LD, Lin CT, Shih YY, Chen YY*, Tsang S, Chang JY. Design, simulation and experimental validations of a novel flexible neural probe for deep brain stimulation and multichannel recording. J Neural Eng, 2012, 9:036001.
Shu TY, Lai HY, Chang YC,et al. The role of the sub-thalamic nucleus in volitional movement termination in Parkinson's disease. Exp Neurol, 2012, 233:253-263.
Liao LD, Lin CT, Shih YY, Lai HY, et al. Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy. J Biomed Opt, 2012, 17:061210.
Liao LD, Lin CT, Shih YY, Duong TQ, Lai HY, et al. Transcranial imaging of functional cerebral hemodynamic changes in single vessels using in vivo photoacoustic microscopy. J Cereb Blood F Met, 2012, 32:938-951.
Huang HY, Hu SH, Chiang CS, Chen SY*, Lai HY, Chen YY*. Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo. J Mater Chem, 2012, 22:8566-8573.
Chen YY*, Cho CW, Lin SH, Lai HY, et al. A vision-based regression model to evaluate parkinsonian gait from monocular image sequences. Expert Syst Appl, 2012, 39:520-526.
Chao WH, Lai HY, Shih YY, et al. Correction of inhomogeneous magnetic resonance images using multiscale retinex for segmentation accuracy improvement. Biomed Signal Proces, 2012, 7:129-140.
Liao LD, Chang YJ, Lai HY, et al. A novel light-addressable multi-electrode array chip for neural signal recording based on VCSEL diode arrays. J NeuroSci NeuroEng, 2012, 1:.4-12.
Chang YJ, Liao LD, Lin CT, Lai HY, et al. A low-cost multielectrode array system for simultaneous acquisition of electrophysiological signal and cellular morphology. J NeuroSci NeuroEng, 2012, 1:131-142.
Lai HY, Chen YY*, Lin SH, et al. Automatic spike sorting for extracellular electrophysiological recording using unsupervised single linkage clustering based on grey relational analysis. J Neural Eng, 2011, 8:036003.
Lee SY*, Su YC, Liang MC, Hong JH, Yang CM, Hsieh CH, Huang MY, Cheng CJ, Chen YY, Lai HY, Lin JW and Fang JQ. A programmable implantable micro-stimulator soc with wireless telemetry: application in close-loop endocardial stimulation for cardiac pacemaker. IEEE T Biomed Circ S, 2011, 5:511-512.
Chen SW, Lin SH, Liao LD, Lai HY, et al. Quantification and recognition of parkinsonian gait from monocular video images using kernel-based principal component analysis. BioMed Eng OnLine, 2011, 10:99.
Liao LD, Li ML, Lai HY, et al. Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy. NeuroImage, 2010, 52:562-570.
Chen YY*, Lai HY, Lin SH, et al. Design and fabrication of a polyimide-based microelectrode array: application in neural recording and repeatable electrolytic lesion in rat brain. J Neurosci Meth, 2009, 182:6-16.
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