Li Jicheng, M.D.

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor


Clinical / Research Interests

Disease biomarker

Tumor morlecular cell biology


Professional Highlights

Zhejiang Scientific and Technical Development Award, Third Prize, 1993

Zhejiang Scientific and Technical Development Award, Second Prize, 1998

Zhejiang Scientific and Technical Development Award, Second Prize, 2000

Chinese Colleges and Universities for Natural Science Award, First Prize, 2001

Zhejiang Scientific and Technical Development Award, Second Prize, 2002

Zhejiang Scientific and Technical Development Award, Second Prize, 2004

Zhejiang Scientific and Technical Development Award, Third Prize, 2006


Professional Appointments

Editorial Board, Bulletin of Science and Technology, 1999-present

Editorial Board, Acta Biologiae Experimentalis Sinica, 2001-present

Editorial Board, Acta Anatomy Sinica, 2006- present

Editorial Board, Neuroembryology and Aging, 2006-present

Editorial Board, Acta Zhejiang University, 2006-present

Editorial Board, Journal of Basic Medicine and Clinic, 2006-present

Editorial Board, Journal of Cell Biology, 2007-presnt

Associate Editor, Anatomical Record, 2007-presnt


Education Experience

Research Summary

Publications

Chen J, Jiang TT, Yi WJ, Jiao JL, Liu CM, Tu HH, Hu YT, Shi LY, Huang H, Li ZB, Gan L, Li ZJ, Li JC*. A group of serum proteins as potential diagnostic biomarkers for Yin-deficiency-heat syndrome. Anat Rec (Hoboken). 2020 Aug;303(8):2086-2094. 

Gan L, Jiang TT, Yi WJ, Lu R, Xu FY, Liu CM, Li ZB, Han YS, Hu YT, Chen J, Tu HH, Huang H, Li JC*. Study on potential biomarkers of energy metabolism-related to early-stage Yin-deficiency-heat syndrome based on metabolomics and transcriptomics. Anat Rec (Hoboken). 2020 Aug;303(8):2109-2120. 

Hu YT, Yi WJ, Jiang TT, Tu HH, Wei LL, Shi LY, Liu CM, Chen J, Han YS, Gan L, Li ZB, Huang H, Li JC*. Serum proteins TGFBI, PCSK9, and CCL14 are potential biomarkers for different traditional Chinese medicine syndromes of multidrug-resistant tuberculosis. Anat Rec (Hoboken). 2020 Aug;303(8):2131-2143.

Yi WJ, Chen J, Li ZB, Jiang TT, Bi DQ, Liu CM, Yang S, Hu YT, Gan L, Tu HH, Huang H, Li JC*. Screening of potential biomarkers for Yin-deficiency-heat syndrome based on UHPLC-MS method and the mechanism of Zhibai Dihuang granule therapeutic effect. Anat Rec (Hoboken). 2020 Aug;303(8):2095-2108.

Li ZB, Han YS, Wei LL, Shi LY, Yi WJ, Chen J, Huang H, Jiang TT, Li JC*. Screening and identification of plasma lncRNAs uc.48+ and NR 105053 as potential novel biomarkers for cured pulmonary tuberculosis. Int J Infect Dis. 2020;92:141-150.

Jiang TT, Li JC*. Review on the systems biology research of Yin-deficiency-heat syndrome in traditional Chinese medicine. Anat Rec (Hoboken). 2020 Jan 7. doi: 10.1002/ar.24354. Online ahead of print.

Huang Huai, Han Yu-Shuai, Chen Jing, Shi Li-Ying, Wei Li-Liang, Jiang Ting-Ting, Yi Wen-Jing, Yu Yi, Li Zhi-Bin, Li Ji-Cheng*. The novel potential biomarkers for multidrug-resistance tuberculosis using UPLC-Q-TOF-MS. Exp Biol Med, 245(6):501-511.

Shen J, Xu J, Chen B, Ma D, Chen Z, Li JC*, Zhu C. Elevated integrin α6 expression is involved in the occurrence and development of lung adenocarcinoma, and predicts a poor prognosis: a study based on immunohistochemical analysis and bioinformatics. J Cancer Res Clin Oncol. 2019 Jul;145(7):1681-1693.

Huang H, Shi LY, Wei LL, Han YS, Yi WJ, Pan ZW, Jiang TT, Chen J, Tu HH, Li ZB, Hu YT, Li JC*. Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis. Clin Chim Acta. Clin Chim Acta. 2019;498:135-142. 

Tu H, Yang S, Jiang T, Wei L, Shi L, Liu C, Wang C, Huang H, Hu Y, Chen Z, Chen J, Li Z, Li J*. Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion. Emerg Microbes Infect. 2019;8(1):448-460. 

Yi WJ, Han YS, Wei LL, Shi LY, Huang H, Jiang TT, Li ZB, Chen J, Hu YT, Tu HH, Li JC*. l-Histidine, arachidonic acid, biliverdin, and l-cysteine-glutathione disulfide as potential biomarkers for cured pulmonary tuberculosis. Biomed Pharmacother. 2019;116: 108980.

Ting-Ting Jiang, Li-Ying Shi, Jing Chen, Li-Liang Wei, Meng Li, Yu-Ting Hu, Lin Gan, Chang-Ming Liu, Zhong-Liang Chen, Su Yang, Hui-Hui Tu, Zhi-Bin Li, Wen-Jing Yi, Zhong-Jie Li, Ji-Cheng Li*. Screening and identification of potential protein biomarkers for evaluating the efficacy of intensive therapy in pulmonary tuberculosis. Biochem Biophys Res Commun. 2018;503(4):2263-2270.

Yuanfeng Zhou, Kuifeng Wang, Ni Zhou, Tingting Huang, Jiansheng Zhu, Ji-Cheng Li*. Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination. Onco Targets Ther. 2018; 11:2007-2015. 

Chang‑Ming Liu, Jing Chen, Su Yang, Ting‑Ting Jiang, Zhong‑Liang Chen, Hui‑Hui Tu, Lian‑Gen Mao, Yu‑Ting Hu, Lin Gan, Zhong‑Jie Li and Ji‑Cheng Li*. iTRAQ‑based proteomic analysis to identify the molecular mechanism of Zhibai Dihuang Granule in the Yin‑deficiency‑heat syndrome rats. Chinese Medicine. 2018, 13:2.

Chang-Ming Liu, Jing Chen, Su Yang, Lian-Gen Mao, Ting-Ting Jiang, Hui-Hui Tu, Zhong-Liang Chen, Yu-Ting Hu, Lin Gan, Zhong-Jie Li, Ji-Cheng Li*. The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses. J Ethnopharmacol. 2018; 225:271-278.

Chong Wang, Su Yang, Chang-Ming Liu, Ting-Ting Jiang, Zhong-Liang Chen, Hui-Hui Tu, Lian-Gen Mao, Zhong-Jie Li, Ji-Cheng Li*. Screening and identification of four serum miRNAs as novel potential biomarkers for cured pulmonary tuberculosis. Tuberculosis. 2018; 108:26-34.

Chen ZL, Wei LL, Shi LY, Li M, Jiang TT, Chen J, Liu CM, Yang S, Tu HH, Hu YT, Gan L, Mao LG, Wang C, Li JC*. Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis. Sci Rep. 2017;7(1):16751. 

Jiang TT, Shi LY, Wei LL, Li X, Yang S, Wang C, Liu CM, Chen ZL, Tu HH, Li ZJ, Ji-Cheng Li*. Serum amyloid A, protein Z, and C4b-binding protein β chain as new potential biomarkers for pulmonary tuberculosis. PLoS One. 2017;12(3): e0173304.

Chang-Ming Liu, Liangen Mao, Ze-Peng Ping, Tingting Jiang, Chong Wang, Zhongliang Chen, Zhong-Jie Li, and Ji-Cheng Li*. Serum protein KNG1, APOC3, and PON1 as potential biomarkers for Yin-deficiency-heat syndrome. Evid Based Complement Alternat Med. 2016; 2016:5176731.

Ting-Ting Jiang, Li-Liang Wei, Li-Ying Shi, Zhong-Liang Chen, Chong Wang, Chang-Ming Liu, Zhong-Jie Li, and Ji-Cheng Li*. Microarray expression profile analysis of mRNAs and long non-coding RNAs in pulmonary tuberculosis with different Traditional Chinese Medicine syndromes. BMC Complement Altern Med, 2016;16(1):472.

Chong Wang, Chang-Ming Liu, Li-Liang Wei, Li-Ying Shi, Zhi-Fen Pan, Lian-Gen Mao, Xiao-Chen Wan, Ze-Peng Ping, Ting-Ting Jiang, Zhong-Liang Chen, Zhong-Jie Li, Ji-Cheng Li*. A group of novel serum diagnostic biomarkers for multidrug-resistant tuberculosis by iTRAQ-2DLC-MS/MS and Solexa sequencing. Int J Biol Sci. 2016;12(2):246-56. 

Zepeng Ping, Tingting Jiang, Chong Wang, Zhongyi Chen, Zhongliang Chen, Jiaxiong Wang, Li Wang, Beibei Wang, Dandan Xu, Changming Liu, Zhongjie Li and Ji-Cheng Li*. The discovery of the synovial lymphatic stomata and lymphatic reabsorption in knee effusion. MICROSC RES TECHNIQ. 2015; 78(6):479-84. 

Ting-Ting Jiang, Chong Wang, Li-Liang Wei, Xiao-Mei Yu, Li-Ying Shi, Dan-Dan Xu, Zhong-Liang Chen, Ze-Peng Ping and Ji-Cheng Li*.  Serum Protein Gamma-Glutamyl Hydrolase, Ig Gamma-3 Chain C Region, and Haptoglobin are Associated with the Syndromes of Pulmonary Tuberculosis in Traditional Chinese Medicine. BMC COMPLEM ALTERN M. 2015; 15:243. 

Chong Wang, Li-Liang Wei, Li-Ying Shi, Zhi-Fen Pan, Xiao-Mei Yu, Tian-Yu Li, Chang-Ming Liu, Ze-Peng Ping, Ting-Ting Jiang, Zhong-Liang Chen, Lian-Gen Mao, Zhong-Jie Li, Ji-Cheng Li*. Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis. SCI REP-UK. 2015; 5:15615. 

Xu DD, Wang C, Jiang F, Wei LL, Shi LY, Yu XM, Liu CM, Liu XH, Feng XM, Ping ZP, Jiang TT, Chen ZL, Li ZJ, Li JC*. Association of the FCN2 Gene Single Nucleotide Polymorphisms with Susceptibility to Pulmonary Tuberculosis. PLoS One. 2015; 10(9): e0138356. 

Jiyan Liu, Tingting Jiang, Feng Jiang, Dandan Xu, Liliang Wei, Chong Wang, Zhongliang Chen, Xing Zhang, Jicheng Li. Comparative proteomic analysis of serum diagnosis patterns of sputum smear-positive pulmonary tuberculosis based on magnetic bead separation and mass spectrometry analysis. Int J Clin Exp Med 2015;8(2):2077-2085

Dandan Xu, Yanyuan Li, Xiang Li, Li-Liang Wei, Zhifen Pan, Ting-Ting Jiang, Zhong-Liang Chen, Chong Wang, Wen-Ming Cao, Xing Zhang, Ze-Peng Ping, Chang-Ming Liu, Ji-Yan Liu, Zhong-Jie Li and Ji-Cheng Li. Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics 2015, 15, 58–67

Xing Zhang, Yanyuan Li, Xiang Li, Wanjiang Zhang, Zhifen Pan, Fang Wu, Chong Wang, Zhongliang Chen,Tingting Jiang, Dandan Xu, Zepeng Ping, Jiyan Liu, Changming Liu, Zhongjie Li and Ji-Cheng Li*. Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations. BMC Infectious Diseases. 2015, 15(1):15:41.

Zhao ZG, Zhang LM, Lv YZ, Si YH, Niu CY, Li JC*. Changes in renal tissue proteome induced by mesenteric lymph drainage in rats after hemorrhagic shock with resuscitation. Shock. 2014; 42(4):350-5.

Liu J, Li Y, Wei L, Yang X, Xie Z, Jiang T, Wang C, Zhang X, Xu D, Chen Z, Yang F, Li JC*. Screening and identification of potential biomarkers and establishment of the diagnostic serum proteomic model for the Traditional Chinese Medicine Syndromes of tuberculosis. J Ethnopharmacol. 2014;155(2):1322-31.

Zi-Gang Zhao, Chun-Yu Niu, Jing-Fu Qiu, Xiao-Dong Chen, and Ji-Cheng Li*. Effect of mesenteric lymph duct ligation on gene expression profiles of renal tissue in hemorrhagic shock rats with fluid resuscitation. Ren Fail. 2014;36(2):271-7.

Dan-Dan Xu, Dan-Feng Deng, Xiang Li, Li-Liang Wei, Yan-Yuan Li, Xiu-Yun Yang, Wei Yu, Chong Wang, Ting-Ting Jiang, Zhong-Jie Li, Zhong-Liang Chen, Xing Zhang, Ji-Yan Liu, Ze-Peng Ping, Yun-Qing Qiu and Ji-Cheng Li*. Discovery and identification of serum potential biomarkers for pulmonary tuberculosis using iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics, 2014;14(2-3):322-331.

Chong Wang, Yan-Yuan Li, Xiang Li, Li-Liang Wei , Xiu-Yun Yang, Dan-Dan Xu, Ting-Ting Jiang, Zhong-Jie Li, Zhong-Liang Chen, Xing Zhang, Ji-Yan Liu, Ze-Peng Ping, Ji-Cheng Li*. Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis. BMC Infectious Diseases. 2014, 14:52.

Chong Wang Zhong-Liang Chen, Zhi-Fen Pan, Li-Liang Wei, Dan-Dan Xu, Ting-Ting Jiang, Xing Zhang, Ze-Peng Ping, Zhong-Jie Li, Ji-Cheng Li*. NOD2 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis. Int J Biol Sci. 2014; 10(1):103-108. 

Jiyan Liu, Tingting Jiang, Liliang Wei, Xiuyun Yang, Chong Wang, Xing Zhang, Dandan Xu, Zhongliang Chen, Fuquan Yang and Ji-Cheng Li*. The discovery and identification of a candidate proteomic biomarker of active tuberculosis. BMC Infectious Diseases 2013, 13:506-517 

Jiaxiong Wang, Zepeng Ping, Tingting Jiang, Hongyuan Yu, Chong Wang, Zhongliang Chen,Xing Zhang, Dandan Xu,Li Wang,Zhongjie Li, and Ji-Cheng Li*. Ultrastructure of Lymphatic Stomata in the Tunica Vaginalis of Humans,Microsc Microanal. 2013;19:1405-1409. 

Zhang X, Guo J, Fan S, Li Y, Wei L, Yang X, Jiang T, Chen Z, Wang C, Liu J, Ping Z, Xu D, Wang J, Li Z, Qiu Y, Li JC*. Screening and Identification of Six Serum microRNAs as Novel Potential Combination Biomarkers for Pulmonary Tuberculosis Diagnosis. PLoS ONE,2013, 8(12): e81076. 

Yuxiang Zhang, Tingting Jiang, Xiuyun Yang, Yun Xue, Chong Wang, Jiyan Liu, Xing Zhang, Zhongliang Chen, Mengyuan Zhao, Ji-Cheng Li*. Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis. PLOS ONE, 2013; 8 (5) e63357

Cao WM, Wang XJ, Li JC*. Study of Hereditary Breast Cancer in the Han Chinese Population. J Epidemiol . 2013;23(2):75-84 

Cao W, Wang X, Gao Y, Yang H, Li JC*. BRCA1 Germ-Line Mutations and Tumor Characteristics in Eastern Chinese Women with Familial Breast Cancer. Anat Rec (Hoboken).2013; 296:273–278.

Xing Zhang, Xiang Li, Wanjiang Zhang,Liliang Wei, Tingting Jiang, Zhongliang Chen, Chunping Meng, Jiyan Liu, Fang Wu, Chong Wang, Ji-Cheng Li*. The novel human MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations. Mol Biol Rep, 2013;40:5073–5083. 

Wang J, Wang Z, Yu H, Wu S, Wang L, Li JC*. The discovery of lymphatic stomata and its ultrastructure in mouse tunica vaginalis. J Pediatr Surg. 2012; 47(11): 2087-92. 

Zhao MY, Xue Y, Zhao ZQ, Li FJ, Fan DP, Wei LL, Sun XJ, Zhang X, Wang XC, Zhang YX, Li JC. Association of CD14G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population. Genetics and Molecular Research, 2012;11(3):3425-3431.

Zhi-Wen Pan, Ji-Cheng Li*. Advances in molecular genetics of Hirschsprung’s disease. Anat Rec 2012,295;1628-1638

  J. Liu, X. Li, N. Yu, Y.-Q. Yang, X. Li, Z.-Y. Ye and Ji-Cheng Li*. Genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene in Chinese patients with gastric cancer. Genet Mol Res 2012, 11(3):2899-2908

Zhi-Wen Pan, Chunfen Luo, Zheng-Ji Liu, Ji-Cheng Li*. RET 3′UTR polymorphisms and its protective role in Hirschsprung disease in Southeastern Chinese. Journal of Pediatric Surgery. 2012;47:1699-1705   

Chong Wang, Tingting Jiang, Liliang Wei, Fujian Li, Xiaojun Sun, Dapeng Fan, Jiyan Liu, Xing Zhang, Dandan Xu, Zhongliang Chen, Zhongjie Li, Xiaoyan Fu, Ji-Cheng Li*. Association of CTLA4 Gene Polymorphisms with Susceptibility and Pathology Correlation to Pulmonary Tuberculosis in Southern Han Chinese. Int J Biol Sci 2012; 8(7):945-952. 

Mengyuan Zhao, Feng Jiang, Wanjiang Zhang, Fujian Li, Liliang Wei, Jiyan Liu, Yun Xue, Xiling Deng, Fang Wu, Le Zhang, Xing Zhang, Yuxiang Zhang, Dapeng Fan, Xiaojun Sun, Tingting Jiang, Ji Cheng Li*. A Novel Single Nucleotide Polymorphism within the NOD2 Gene is Associated with Pulmonary Tuberculosis in the Chinese Han, Uygur and Kazak Populations. BMC infective disease 2012; 12:91-103.

Xiang Li, Xiang Li, Jiaxiong Wang, Zaiyuan Ye, Ji-Cheng Li*. Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells. International Journal of Biological Sciences. 2012; 8(6):901-912. 

Yueqin Yang, Jia Liu, Xiang Li, Ji-Cheng Li*. PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer. Histology and Histopathology. 2012; 27: 217-224

Xing Zhang, Feng Jiang, Liliang Wei, Fujian Li, Jiyan Liu, Chong Wang, Menyuan Zhao, Tingting Jiang, Dandan Xu, Dapeng Fan, Xiaojun Sun, Ji-Cheng Li*. Polymorphic Allele of Human MRC1 Confer Protection against Tuberculosis in a Chinese Population. Int. J. Biol Sci., 2012; 8(3):375-382.

Yueqin Yang, Ji-Cheng Li*. Progress of research in cell-in-cell phenomena. Anat Rec. 2012, 295: 372-377.

Jiang, Lei, Lai, Yiu-Kay, Zhang, Jin-Fang, Chan, Chu-Yan, Lu, Gang, Lin, Marie C. M., He, Ming-Liang, Li, Ji-Cheng*, Kung, Hsiang-Fu*. Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-beta-susceptible hepatocellular carcinoma cells. World Journal of Gastroenterology, 2012,5: 18(17): 2035-2042

Ji-Yan Liu, Lei Jin, Meng-Yuan Zhao, Xin Zhang, Chi-Bo Liu, Yu-Xiang Zhang, Fu-Jian Li, Jian-Min Zhou, Hua-Jun Wang and Ji-Cheng Li*. New serum biomarkers for detection of tuberculosis using surface-enhanced laser desorption/ionization time-of-flight masss pectrometry. Clin Chem Lab Med 2011;49(10):1727-1733.

Yuxiang Zhang, Yun Xue, Jiyan Liu, Mengyuan Zhao, Fujian Li, Jianmin Zhou, Huajun Wang, Ji-Cheng Li*. Association of TIRAP (MAL) gene polymorphisms with susceptibility to tuberculosis in a Chinese population. Genetics and  Molecular Research, 2011;10(1):7-15

Zhi-Wen Pan, Jin-Tu Lu, Linjun Yu, Ji-Cheng Li*. Association analysis of the SOX10 polymorphism with Hirschsprung disease in the Han Chinese population. JOURNAL OF PEDIATRIC SURGERY 2011;46:130-134

Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lina, Ji-Cheng Li*, Haixiao Chen. Hydrogenper oxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. Neuroscience Letters 2010; 485 :60–64

Yunqing Qiu, Liqian Xu, Yanghuai Zhou, Ming Shi,Yingyu Ma, Meng Li, Jicheng Li*. Involvement of  Genetic Instability in the Down regulation of sFRP1 in Chinese Patients With Hepatocellular Carcinoma. THE ANATOMICAL RECORD293:2020–2026(2010) 

Yun Xue, Lei Jin, A-Zhong Li, Hua-Jun Wang, Meng Li, Yu-Xiang Zhang, Yu Wang and Ji-Cheng Li*. Microsatellite polymorphisms inintron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese. Clin Chem Lab Med 2010;48(6):552-556.

Meng Li, Xiang Li, and Ji-Cheng Li*. Possible mechanisms of trichosanthin-induced apoptosis of tumor cells. Anat Rec 2010,293(6)986-992.

Dun Hong, Hai-Xiao Chen, Renshan Ge, Ji-Cheng Li*. Genetically Engineered mesenchymal stem cells: The ongoing research for bone tissue engineering. Anat Rec 2010,293:531-537.

Cui-Ping Liu, Qian-Qian Tang, Jin-Tu Lou, Chun-Fen Luo, Xue-Wu Zhou, Dong-Mei Li, Fei-Chen, Xiang Li, Meng Li, Ji-Cheng Li*. Association analysis of the RET proto-oncogene with Hirschsprung Disease in the Han Chinese population of Southeastern China. Biochem Genet 2010,48:496-503.

Zi-Bin Wang, Meng Li, Ji-Cheng Li*. Recent advances in the research of lymphatic stomata. Anat Rec 2010,293:754-761.

Lei Jiang, Yangchao Chen, Chu-Yan Chan, Gang Lu, Hua Wang, Ji-Cheng* and Hsiang-Fu Kung*. Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development. Anat Rec 2010,293:858-864

Li M, Chen F, Liu CP; Li DM, Li X, Wang C, Li JC*. Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line. Life Sci. 2010, 86(1)10-16. 

Xue Y, Zhao ZQ, Hong D, Zhao MY, Zhang YX, Wang HJ, Wang Y, Li JC*. Lack of association between MD-2 promoter gene variants and tuberculosis. Genet Mol Res. 2010 Aug 17;9(3):1584-90.

Xue Y, Zhao ZQ, Wang HJ, Jin L, Liu CP, Wang Y, Li JC*. Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis. Int J Immunogenet. 2010;37(2):135-8.

Cui-Ping Liu, Xin-Gang Li, Jin-Tu Lou, YunXue, Chun-Fen Luo, Xue-Wu Zhou, Fei-Chen, Xiang Li, Meng Li, Ji-Cheng Li*. Association analysis of the PHOX2B  gene with Hirschsprung disease in the Han Chinese population of Southeastern China. Journal of Pediatric Surgery  2009;44(9):1805-1811.

Dun-Hong, Hai-Xiao Chen,Yun Xue, Dong-Mei Li, Xiao-Chen Wan, Renshan Ge, Ji-Cheng Li*. Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells. Journal of Steroid Biochemistry & MolecularBiology 2009;116:86–92.

Marong Fang, Zhiying Hu, Yan Li, Ji-Cheng Li*, David T Yew. Nestin positive cells in the retina and spinal cord of the sturgeon after hypoxia. International Journal of Neuroscience 2009;119-460.

Lei Jiang, Yangchao Chen, Chu-yan Chan, Xin Wang, Lin Lind, Ming-liang He, Marie C.M. Line, David T. Yew, Joseph J.Y. Sung, Ji-Cheng Li*, Hsiang-fu Kung*. Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells. Cancer Letters, 2009;274:101-108. 

Yingyu Ma, Liang Wu, Cuiping Liu, Liqian Xu, Dongmei Li and Ji-Cheng Li*. The correlation of genetic instability of PINX1 gene to clinico- pathological features of gastric cancer in the Chinese population. J Cancer Res Clin Oncol. 2009, 135(3):431-7.

Ping Wang, Li-Li Chen, Hui Yan, Ji-Cheng Li*. Trichosanthin suppresses Hela cell proliferation through inhibition of the PKC/MAPK signaling pathway. Cell Biol Toxicol. 2009;25:479-488.

Xiao-Chen Wan ,Cui-Ping Liu ,Meng Li ,Dun Hong, Dong-Mei Li a, Hai-Xiao Chen, Ji-Cheng Li*. Staphylococcal enterotoxin C injection in combination with ascorbic acid promotes the differentiation of bone marrow-derived mesenchymal stem cells into osteoblasts In vitro. Biochemical and Biophysical Research Communications. 2008;373:488–492.

Cuiping Liu, Lei Jin, Hui Li, Jintu Lou, Chunfen Luo, Xuewu Zhou ,Ji-Cheng Li*. RET polymorphisms and the risk of Hirschsprung’s disease in a Chinese population. J Hum Genet 2008;53:825–833.

Dun Hong, Hai-Xiao Chen, Ren-Shan Ge, Ji-Cheng Li*. The biological roles of extracellular and intracytoplasmic glucocorticoids in skeletal cells. Journal of Steroid Biochemistry & Molecular Biology 2008; 111:164–170.

Yue-Qin Yang, Liang Wu, Jin-Xing Chen, Jian-Zhong Sun, Meng Li, Dong-Mei Li, Hai-Ying Lu, Zhi-Hong Su, Xin-Qiu Lin, Ji-Cheng Li*. Relationship between nm23H1 genetic instability andclinical pathological characteristics in Chinese digestivesystem cancer patients. World J Gastroenterol 2008; 14(32):

 Zeran Yang, Ji-Cheng Li*. Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3β signaling in endothelial cells. Life Sciences 2008;82:512-518.

Lanhai Lu, Ji-Cheng Li, Yonghong Zhu, Ying T Mak, David T Tew. H2O2-induced changes in astrocytic cultures from control and rapidly aging strains of mouse. International Journal of Neuroscience 2008;118:1239-1250.

Lü, L.H., Li, J.C., Yew, D.T., Rudd, J.A., Mak, Y.T. Oxidative stress on the astrocytes in culture derived from a senescence accelerated mouse strain. Neurochem.Int. 2008;52:282-289.

Zan Shen, Zhen Fan Yang, Yi Gao, Ji-Cheng Li, et al. The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinoma. Cancer Res 2008;68(2):404-414.

Yan-Yuan Li, Ji-Cheng Li*. A Cell Signal Transduction Mechanism for Nitric Oxide Regulating Lymphatic Stomata and its Draining Capability. Anat Rec 2008;291(2):216-223.

Wang P, Yan H, Li JC*. CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis. Biochem Biophys Res Commun 2007 363(1):101-105.

Wang P, Li JC*. Trichosanthin-induced specific changes of cytoskeleton configuration were associated with the decreased expression level of actin and tubulin genes in apoptotic Hela cells. Life Sci 2007 81(14):1130-1140.

 Meng Li, Tian-Hua Zhou, Yun Gao, Ning Zhang, Ji-Cheng Li*. Ultrastructure and estrogen regulation of the lymphatic stomata of ovarian bursa in mice. Anat Rec 2007;290(10):1195-1202.

 Xian-Ning Zhang, Miao-Ni Zhou, Yun-Qing Qiu, Shi-Ping Ding, Ming Qi, Ji-Cheng Li*. Genetic analysis of RET, EDNRB, and EDN3 genes and three SNPs in MCS+9.7 in Chinese patients with isolated Hirschsprung disease. Biochem Genet 2007;45:523-527.

Rui Yu, Xian-Ning Zhang, Xiao-Xiao Huang, Shi-Ping Ding, Ji-Cheng Li*. Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. Am J Med Genetics2007;144B570-573.

Lan-Hai Lu, Ji-Cheng Li, Maria Sen Mun Wai, Wai Ping Lam, E.Lucy Forster, Ma-Rong Fang, David T. Yew. Perinatal hypoxia induces subsequent retinal degeneration in the offspring of ovoviviparous fish, Xiphophorous maculates. Veternary Ophthalmology 2007;10(5):289-294.

Liang Y, Fang M, Li JC, Yew DT. Vagus, hypoglossal, and median nerves in human development. Intern J Neuroscience,2007, 117:453-464.

Liang Y, Fang M, Li JC, Yew DT. Immunohistochemical localization of endothelial isoform (eNOS) in human cerebral arteries and the aorta. International Journal of Neuroscience, 2006;116(12):1403-17

Niu CY, Li JC*. Effect of intestinal lymphatic circulation blockage in two-hit rats. World J Gastroenterol. 2006,28;12(36):5805-12.

Yong Liang, Marong Fang, Ji-Cheng Li, et al. Serum proteomic patterns for gastric lesions as revealed by SELDI mass spectrometry. Experimental and Molecular Pathology 2006 Oct;81(2):176-80.

Marong Fang, Ji-Cheng Li, John A.Rudd,Sen Mun Wai,Jason C.C.Yew,Dacid T.Yew. fMRI Mapping of cortical centers following visual stimulation in postnatal pigs of different ages. Life Sciences 2006;78(11):1197-1201. 

Liang Y, Fang M, Li J, Yew DT. Immunohistochemical localization of endothelial isoform (eNOS) in human cerebral arteries and the aorta. International Journal of Neuroscience, 2006;116(12):1403-1417.

Jiaoyang Yin, Ji-Cheng Li, Yegang Ma, Li Guo, Huiwen Wang, Ulla Vogel. The DNA repair gene ERCC2/XPD polymorphism Arg 156Arg (A22541C) and risk of lung cancer in a Chinese population. Cancer Letters 2005;223:219-226. 

Fang MR, Zhang LH, Li JC, et al. The postnatal development of the cerebellum - A fMRI and silver study. Cellular and Molecular Neurobiology 2005; 25 (6): 1043-1050.

 Fang MR, Lorke DE, Li JC, Gong XY, Yew JCC, Yew DT. Postnatal changes in functional activities of the pig's brain: A combined functional magnetic resonance Imaging and immunohistochemical study. NEUROSIGNALS 2005;14 (5): 222-233.

Zhang XN, He XH, Yin WG, Le YP, Guo JM, Mao W, He XL, Li JC*. An insertion-deletion mution in keratin 9 in three Chinese families with epidermolytic palmoplantar keratoderma. British J Dermatology 2005;152:803-829.

 Jiaoyang Yin, Ji-Cheng Li, Ulla Vogal, Huiweng Wang. Polymorphisms of DNA repair genes: ERCC1 G19007A and ERCC2/XPD C22541A in a northeastern Chinese population. Biochemical Genetics 2005;43:543-548.

 Marong Fang, Mingwei Wang, Renshi Qing, Lihong Zhang, Ji-Cheng Li*, David T Yew. The role of nitric oxide in nerodegerative diseases and dementia. Current Trends in Neurology 2005;1:81-90.

 Marong Fang, Ji-Cheng Li*, Tiu SC, et al. N-Methyl-D-Aspartate receptor and apoptosis in Alzheimer’s disease and multi-infarct dementia. J Neuroscience Res 2005;81:269-274.

 Marrong Fang, Ji-Cheng Li*, Kwong WH, Kindler P, Gang Lu, Sen Mun Wai, Davin Yew. Myelination of the pig’s brain: A correlated MRI and histological study. Neurosignals 2005;14:102-108.

 Marrong Fang, Ji-Cheng Li*, Gang Lu, Xiangyang Gong, Davin Yew. A fMRI study of age-related differential cortical patterns during cued motor movement. Brain Topongraphy 2005;17(3)127-137.

 Marrong Fang, Ji-Cheng Li*, Wai SM, Kwong WH, Kung LS, Yew DT. Retinal twin cones or retinal double cones in fish: misnomer or different morphological forms? Intern J Neuroscience 2005;115:1002-1009.

 Tao Guan, Ji-Cheng Li*, Min-Ju Li, jin-Fa Tou. Polymerase chain reaction-single strand conformational polymorphism analysis of rearranged during transfection proto-oncogene in Chinese familial hirschsprung’s disease. WGJ2005;11(2):275-279.

 Yong Liang, Ji-Cheng Li*. Relationship between genetic instability of gene NM23H1 、BRCA1 and clinical pathological behaviors in gastric cancer of Chinese patients. J Tumor Marker Oncology, 2004;19(4): 63-64.

 Marrong Fang, Ji-Cheng Li*, Kwong WH, Kindler P, Gang Lu, Sen Mun Wai, Davin Yew. The complexity of the visual cells and visual pathways of the sturgeon. Microscopy Research and Technique 2004;65:122-129.

 Su ZH, Li JC*. Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients. WGJ 2004;10(19):2800-2804.

 Chang-Ming Dou, Ji-Cheng Li*. Effect of extracts of trichosanthes root tubers on HepA-H cells and HeLa cells. WGJ2004;10(14):2091-2094.

 Chang-Ming Dou, Ji-Cheng Li*. Effect of extracts of trichosanthes root tubers on HepA-H cells and HeLa cells. WJG;2004;10(14):2091-2094.

 Yan-Yuan Li, Ji-Cheng Li*. Ultrastructural study of pleural lymphatic drainage unit and effect of nitric oxide on the drainage capacity of pleural lymphatic stomata in the rat. Ann Anat 2004; 186: 25-31.

 Hui Li, Ji-Cheng Li*. Development of the Peritoneal Lymphatic Stomata and Diaphragm Lymphatic Vessels in Mice. Ann Anat 2003;185:411-418.

Yan-Yuan LI, Ji-Cheng Li*. Ultrastructure and three-dimensional study of the lymphatic stomata in the costal pleura of the rabbit. Microscopy Research and Technique 2003;62(3)240-246.

Ding SP, Li JC*, Jin C. An mouse model of severe acute pancreatitis induced with caerulein and lipopolysaccharide. World Journal of Gastroenterology 2003,9(3):584-589.

 Ji-Cheng Li*, Shiping Ding, Ying Song, Minju Li. Mutation of RET gene in Chinese patients with Hirschsprung’s disease. World Journal of Gastroenterology 2002,8(6):1108-111.

 Li JC, Ding SP, Xu J. Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice. World J Gastroenterol 2002;8(2):333-337.

 Ding SP, Li JC* Xu J. Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine. World J Gastroenterol 2002;8(1)188-192.

 Li JC.The development of colon innervation in trisomy 16 mice and Hirschsprung’s disease. World J Gastroentero 2001;7(1):16-21.

 Li JC*.Study on regulating effect of Chinese herbal medicine in peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis. CJIM 2001:7(2):247-251.

 Ji-Cheng Li, Kuhnel W. Immunohistochemical study on the gastroenteric nervous system in trisomy 16 mice- an animal model of Down syndrome. World J Gastroentero 2000,6(6):793-799.


Current Program

Ultrastructural and computer image studies on human peritoneal lymphatic stomata. Funding Source: National Natural Science Foundation.

The study on human pericardial lymphatic stomata and the mechanism of lymphatic drainage from the pericardial cavity. Funding Source: National Natural Science Foundation.

The discover of the meningeal lymphatic stomata and pathophysiological study. Funding Source: National Natural Science Foundation.

Study on the regulation mechanism of the peritoneal lymphatic stomata and the treatment of cirrhosis ascites by using traditional Chinese medicine. Funding Source: National Natural Science Foundation.

Study on the development and nitric oxide regulation of the peritoneal lymphatic stomata in human. Funding Source: National Natural Science Foundation.

The regulation of endogenous nitric oxide from Chinese material medica on the peritoneal lymphatic stomata and the effect of NO-cGMP independent way. Funding Source: National Natural Science Foundation.

The development, lymph drainage mechanism and reproductive physiological function of the ovarian lymphatic stomata. Funding Source: National Natural Science Foundation.

Study on the mechanism and effect of recombinant trichosanthin selective anti-tumor from Trichosanthes kirilowii maximowicz. Funding Source: National Natural Science Foundation.

National Science Base: Talent cultivation. Funding Source: National Natural Science Foundation.

National Science Base: Construction of teaching condition.Funding Source: National Natural Science Foundation.

The study on serum protein fingerprint pattern of Chinese medical science symptom in tuberculosis. Funding Source: National Natural Science Foundation.

Screening and identifying of new serum biomarkers for TCM syndrome in pulmonary tuberculosis by iTRAQ-2DLC-MS/MS. Funding Source: National Natural Science Foundation.

Study on the law of TCM symptoms of pulmonary tuberculosis and the treatment plan of integrated TCM and Western medicine. Funding Source: National "Eleventh Five-Year Plan" Major Science and Technology Projects.

Establishment and clinical application of the protein spectrum diagnosis model for pulmonary tuberculosis based on serum proteomics. Funding Source: Priority Theme of Zhejiang Major Science and Technology Projects.

Bioinformatic research of TCM syndromes for pulmonary tuberculosis based on translational medicine. Funding Source: National "Twelfth Five-Year" Major Science and Technology Projects.

Study on the mechanism of nourishing Yin and decreasing internal heat fire recipe in treating Yin Deficiency "Shanghuo". Funding Source: National 973 Project.

Screening, identification and functional analysis of Serum Protein Biomarkers for TCM Syndrome differentiation of Drug-Resistant Tuberculosis. Funding Source: National Natural Science Foundation.

Screening, identification and functional analysis of new biomarkers as lncRNA/T-UCRs for active pulmonary tuberculosis. Funding Source: National Natural Science Foundation.

Screening, identification and functional analysis of Serum Protein Biomarkers for Drug-Resistant Tuberculosis. Funding Source: Natural Science Foundation of Guangdong Province.


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