Department：Neurology
Medical School：Baylor College of Medicine, Houston, Texas, USA
Academic Rank：Associate Professor
Molecular and neural circuitry mechanisms underlying neuropsychiatric diseases
Committee Member, Zhejiang Society for Neuroscience Neurology, 2018-present
Dr. Lian has been working on the molecular mechanisms involving the signaling receptors, especially the complement receptor C3aR and the schizophrenia risk factor ErbB4, for psychiatric disorders. She is extending her research interests to neural circuits underlying mental illnesses, especially depression and anxiety disorders.
Cao SX#, Zhang Y#, Hu XY, Hong B, Sun P, He HY, Geng HY, Bao AM, Duan SM, Yang JM, Gao TM, Lian H*, Li XM*, ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines, eLife, 2018, 7:e39907.
Lian H#, Litvinchuk A#, Chang A, Aithmitti N, Jankowsky JL and Zheng H*, Astrocyte-microglia crosstalk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease, Journal of Neuroscience, 2016, 36(2):577-589.
Lian H and Zheng H*, Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease, Journal of Neurochemistry, 2016, 136(3)：475-491.
Lian H, Yang L, Cole A, Sun L, Chang A, Fowler S, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC and Zheng H*, NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease, Neuron, 2015, 85(1):101-115.
Molecular Mechanisms of the Transcriptional repressor CtBP2 in the dorsal hippocampal CA3 in spatial memory regulation. Funding Source: National Natural Science Foundation of China.
Molecular Mechanisms of ErbB4 in the Regulation of the Morphology and Function of Medium Spiny Neurons. Funding Source: Natural Science Foundation of Zhejiang.
The Effect of Inhibiting the Complement Receptor C3aR in Epilepsy Pathophysiology. Funding Source: Zhejiang University Basic Research Funding.
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