Department：Orthopedics
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Professor
Intestinal immunity
Autoimmune diseases
Microbiota
Allergic responses
Young Investigator Award of Chinese Society for Immunology
Zhejiang Young Investigator Award Zhejiang Society for Immunology
Dr. Lin mainly engaged in the regulatory signaling pathways and molecular mechanisms of autoimmune diseases and inflammation.
During the Ph.D., he focused on the role of Raf kinase inhibitory protein (RKIP) in inflammatory bowel disease. He found that the expression of RKIP in intestinal epithelial cells of patients with inflammatory bowel disease was significantly increased, and the change of RKIP expression was positively correlated with the pathogenesis of human inflammatory bowel disease. In vivo, RKIP deletion attenuated the pathogenesis of inflammatory bowel disease in mice. Further studies demonstrated that RKIP promotes the activation of P65/PUMA/Caspase3 signaling pathway by enhancing TAK1 oligomerization and autophosphorylation to enhance the IECs apoptosis, suggesting that RKIP may be a new diagnostic and therapeutic target for inflammatory bowel disease. The related research work was published in Gut 2017; in addition, he found that RKIP regulates IL-17R signaling pathway to modulate IL-17R-associated inflammation and autoimmune diseases. And this study was published in EMBO Reports 2018.
Furthermore, he found that the protein kinase NDR1 is involved in the regulation of the IL-17R signaling pathway associated inflammatory response and autoimmune diseases. The relevant content was published in EMBO Reports 2017.
Wenlong Lin#, Fasheng Su#, Rahul Gautam#, Ning Wang, Yuanyuan Zhang, Xiaojian Wang*. Raf kinase inhibitor protein negatively regulates FcεRI-mediated mast cell activation and allergic response.Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9859-E9868.
Wenlong Lin#, Ning Wang#, Kangxing Zhou#, Fasheng Su, Yang Jiang, Jianan Shou, Huan Liu,Chunmei Ma,Youchun Qian, Kai Wang, Xiaojian Wang*.RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling. EMBO Rep. 2018 Jun;19(6). pii: e44951.
Yu Jiang#, Miao Tian#, Wenlong Lin#, Xinyuan Wang, Xiaojian Wang*. Protein Kinase Serine/Threonine Kinase 24 Positively Regulates Interleukin 17-Induced Inflammation by Promoting IKK Complex Activation.Front Immunol. 2018 Apr 30;9:921.
Wenlong Lin#, Chunmei Ma, Fasheng Su, Yu Jiang, Rongrong Lai, Ting Zhang, Kai Sun, Liping Fan, Zijian Cai, Zhongqi Li, He Huang, Jun Li*, Xiaojian Wang*. Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.Gut. 2017 Apr;66(4):597-610.
Chunmei Ma#, Wenlong Lin#, Zhiyong Liu, Wei Tang, Rahul Gautam, Hui Li, Youchun Qian, He Huang, Xiaojian Wang*. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF. EMBO Rep. 2017 Apr;18(4):586-602.
The function of RKIP in mast cell mediated allergy and its molecular mechanisms. Funding Source: National Natural Science Foundation of China.
Regulatory role and its mechanism of protein kinase serine/threonine kinase 24 (STK24) in human and mice inflammatory bowel disease. Funding Source: National Natural Science Foundation of China.
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