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Liu Yang, Ph.D.

Department：Orthopedics

Medical School：Zhejiang University School of Medicine, China

Academic Rank：Associate Professor



Clinical / Research Interests

Tumor immunology

Innate immunology

The differentiation and development of immune cells


Professional Highlights

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Education Experience

Research Summary

Dr. Liu mainly focuses on the cellular and molecular mechanisms of innate host defense in tumorigenesis and pathogen defense. His previous work has revealed several new mechanisms for regulating the innate immunity in macrophages and MDSC, including illuminating the critical role of E3 ligase FBXW7 in inflammatory response and production of type I interferon. 

Publications

Song, Y., L. Lai, Z. Chong, J. He, Y. Zhang, Y. Xue, Y. Xie, S. Chen, P. Dong, L. Chen, Z. Chen, F. Dai, X. Wan, P. Xiao, X. Cao, Y. Liu, and Q. Wang. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. 2017. Nat Commun. 8:14654. (co-corresponding author)

Chen, L., Y. Song, L. He, X. Wan, L. Lai, F. Dai, Y. Liu, and Q. Wang. MicroRNA-223 Promotes Type I Interferon Production in Antiviral Innate Immunity by Targeting Forkhead Box Protein O3 (FOXO3). 2016. The Journal of biological chemistry. 291:14706-14716. (co-corresponding author)

Liu, Y., L. Lai, Q. Chen, Y. Song, S. Xu, F. Ma, X. Wang, J. Wang, H. Yu, X. Cao, and Q. Wang.MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN.  2012. J Immunol. 188:5500-5510.


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