Liu Hua, M.D., Ph.D.

Department:Orthopedics

Medical School:National University of Singapore, Singapore

Academic Rank:Associate Professor



Clinical / Research Interests

Basic and translational research regarding mesenchymal stem cells regeneration

Allogeneic immune properties of mesenchymal stem cells

Mutual effect of mesenchymal stem cells and an inflammatory/biodegradable scaffold microenvironment in regenerative medicine


Professional Highlights

Science Technology Improvement Award of Science Research Famous Achievement Award in Higher Institution, Ministry of Education of the People's Republic of China, First Prize, 2019

Second Online Course and Teaching Resource Competition of MOOC (micro video section), Educational Technology Branch of Chinese Medical Association, Third Prize, 2019 

The 9th Teaching Skill Competition of Young Teachers, Department of Education of Zhejiang Province, Excellent Teacher Award, 2016

Teaching Skill Competition of Young Teachers, Zhejiang University, Second Prize, 2015


Professional Appointments

Vice-Chair, Youth Committee, Zhejiang Anatomy Society, 2020

Committee Member, Obstetrics and Gynecology Branch, Zhejiang Society of Translational Medicine, 2018

Member, Chinese Society of Anatomical Sciences, 2018

Committee Member, Organ Transplantation Branch, Chinese Medical Doctor Association, 2017

Chief Editor, Stem Cells International (Special Issue), 2015


Education Experience

Research Summary

She has investigated the mechanism of low-immunogenicity of mesenchymal stem cells in the respect of Major Histocompatibility Complex-I and is constructing allo-immune compatible stem cells with CRISPR-Cas9 technique. 

Besides, she is working on the interaction and the effect of biomaterials, immune microenvironment and stem cells on tissue regeneration.


Publications

Wang Y, Tian M, Wang F, Heng BC, Zhou J, Cai Z, Liu H. Understanding the Immunological Mechanisms of Mesenchymal Stem Cells in Allogeneic Transplantation: From the Aspect of Major Histocompatibility Complex Class I. Stem Cells and Development 2019;28(17):1141-1150.

Wang Y, Huang J, Gong L, Yu D, An C, Bunpetch V, Dai J, Huang H, Zou X, Ouyang H, Liu H. The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I. iScience. 2019 May 31;15:66-78.

Wei W, Zhang Q, Zhou W, Liu Z, Wang Y, Alakpa EV, Ouyang H, Liu H. Immunomodulatory application of engineered hydrogels in regenerative medicine. Applied Materials Today. 2019 Mar 4;14 :126-136.

Sharifi F, Htwe SS, Righi M, Liu H, Pietralunga A, Yesil-Celiktas O, Maharjan S, Cha BH, Shin SR, Dokmeci MR, Vrana NE, Ghaemmaghami AM, Khademhosseini A, Zhang YS. A Foreign Body Response-on-a-Chip Platform. Advanced Healthcare Materials. 2019 Feb;8(4):e1801425.

Lei P, Dai Z, Zhang Y, Liu H, Nu W, Li K, Wang L, Hu Y, Xie J. Macrophage inhibits the osteogenesis of fibroblasts in ultrahigh molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis. Journal of Orthopaedic Surgery and Research. 2019 Mar 18;14(1):80-86.

Wang Y, Yu D, Liu Z, Zhou F, Dai J, Wu B, Zhou J, Heng BC, Zou XH, Ouyang H, Liu H. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Research & Therapy 2017;8(1):189-202.                                       

Wang J, Wang J, Lu P, Cai Y, Wang Y, Hong L, Ren H, Heng BC, Liu H, Zhou J, Ouyang H. Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis. Biomaterials. 2015 Sep;62:76-87. 

Liu H, Zhiyong Zhang, Wei Seong Toh, Kee Woei Ng, Shilpa Sant, António Salgado.Stem Cells: Microenvironment, Micro/Nanotechnology, and Application.Stem Cells International. 2015; Article Number: 398510.

Liu H, Xu GW, Wang YF, Zhao HS, Xiong S, Wu Y, Heng BC, An CR, Zhu GH* and Xie DH. Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop. Biomaterials. 2015 May;49:103-12.


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