Department: Lab of Cardiovascular Disease Diagnosis and Treatment
Medical School: Texas A&M University, U.S.
Academic Rank: Distinguished Professor
Bioinformatics
Computational epigenetics
Poster Award, Cancer Center Epigenetics Annual Retreat, 2011
Fellowship Genboree Workshop on Epigenome Informatics, 2012
Fellowship to "RNA 2013-The 18th annual meeting of the RNA Society", 2013
Award to "V. Else Kröner-Fresenius Symposium on Adult Stem Cells", 2013
Election to full member of Sigma Xi, 2014
Fellowship to "RNA 2014-The 19th annual meeting of the RNA Society", 2014
Oral Presentation Award, 31th Annual Symposium of the Society of Chinese Bioscientists in America (SCBA-TX), Third Place, 2017
Oral Presentation Award for GSO Symposium, First Place, 2019
Member, International Society of Computational Biology, 2012-present
Member, American Society for Cancer Research, 2014-present
Honorary Fellow, Sigma Xi Honor Society, 2014-present
Member, SCBA-TX, 2014-present
Judge for US-China Innovation and Investment Summit, Houston, 2017
Reviewer, National Natural Science Foundation of China, 2018-present
Research in bioinformatics and computational epigenetics with specialties in developing statistical methods and biological information software to analyze high-throughput sequencing data such as Bisulfite-Seq, ATAC-Seq, HiC-Seq, MeDIP-Seq, ChIP-Seq, RNA-Seq, TAB-Seq, Mnase-Seq, Genome-Seq, scRNA, scATAC, scRRBS.
Johnson G, Rajendran P, Li L, Chen Y, Dashwood W, Nguyen N, Ulusan A, Ertem F, Zhang M, Sun D, Huang Y, Wang S, Leung H, Lieberman D, Beaver L, Ho Emily, Bedford Mark, Chang K, Vilar E, Dashwood R. (2019) CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. Cancer Research 79 (13 Supplement), 2614-2614
Lei Guo, Jia Li, Hongxiang Zeng, Anna Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Clifford Stephan, Peter JA Davies, Margaret Goodell, Deqiang Sun, Mark A Dawson, Yun Huang. (2019) A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells. Blood, The Journal of the American Society of Hematology 134
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao W, Dashwood R, Han L, Zhou Y, Dong W, Huang Y. (2018) p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Blood 132 (Suppl 1), 2610
Fang S, Xiao Y, Li J, Li T, Zeng H, Han W, Zhou Y, Sun D, Martin J, Huang Y. (2018) Tet2 Deficiency in Macrophages Undermines Heart Repair after Infarction. Blood 132 (Suppl 1), 2394
Guo L, Li J, Fang S, Lee M, Zeng H, Li T, Han W, Sun D, Huang Y. (2018) Synthetic Lethality of Combinatory Inhibition of BET and CDK7 in BET (i) Resistant Leukemia Cells. Blood 132 (Suppl 1), 1354-1354
Lee M, Zeng H, Li J, Han W, Sun D, Huang Y. (2018) Disruption of TET2 Dioxygenase Enhances Antitumor Efficiency in CD8+ Tumor Infiltrating Lymphocytes. Blood 132 (Suppl 1), 860-860
F Ertem, W Zhang, K Chang, W Dashwood, P Rajendran, D Sun, A Abudayyeh, M Abdulrahim, E Vilar, R Dashwood. (2017) Prevention by tolfenamic acid and characterization of the molecular targets in Pirc and FAP colorectal adenomas. Cancer Research 77 (13 Supplement), 2229
S Zang, J Li, H Yang, W Han, J Zhang, M Lee, Y Zhou, D Sun, Y Huang. (2017) TET2 loss and the lymphoma-associated RHOA mutation cooperate to disrupt CD4+T cell function. Cancer Research 77 (13 Supplement), 5379
K King, K Matatall, S Chen, M Jeong, D Sun, F Chen, Q Mo, M Kimmel. (2016) Terminal differentiation is the major route of HSC loss during chronic infection. Experimental Hematology 44 (9), S44
K King, K Matatall, S Chen, M Jeong, D Sun, F Chen, Q Mo, M Kimmel. (2016) Terminal Differentiation Is the Major Route of Hematopoietic Stem Cell Loss During Chronic Infection. Open Forum Infectious Diseases 3 (suppl 1), 901
G Challen, A Mayle, D Sun, et. al.. (2013) De novo DNA methylation is required for maintaining genomic and transcriptional integrity in hematopoietic stem cells. Experimental Hematology 41 (8), S14.
A Mayle, D Sun, M Jeong, et. al.. (2013) Dnmt3b Has Few Specific Functions In Adult Hematopoietic Stem Cells But Shows Abnormal Activity In The Absence Of Dnmt3a. Blood 122 (21):734.
M Jeong, D Sun, HJ Park, et. al.. (2013) Long Non-Coding RNAs Control Hematopoietic Stem Cells (HSC) Function. Blood 122 (21):48.
M Jeong, D Sun, M Luo, et. al.. (2013) Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a. Blood 122 (21):2406.
A Mayle, GA Challen, D Sun, et. al.. (2012) Dnmt3b Is Dispensable for Hematopoietic Stem Cell Differentiation, but Acts Synergistically with Dnmt3a to Control the Balance Between Self-Renewal and Differentiation. Blood 120 (21).
M Jeong, M Luo, D Sun, et. al.. (2012) HSC Aging Epigenome: Widespread Alterations in DNA Methylation and Transcription. Blood 120 (21).
A Kosters, D Sun, F Tian, et. al.. (2012) Novel sex-differential Retinoid X Receptor alpha binding sites in mouse liver by genome-wide chromatin analysis. Hepatology 56, 245A.
M Jeong, D Sun, M Luo, et. al.. (2011) Genome Wide DNA Methylation and Transcriptome Analysis in HSC Aging. Blood 118 (21), 1020.
Research on the role of methylation in early cancer diagnosis mainly uses liquid biopsy. We have successfully used cell-free DNA in the blood and CSF to do whole-genome methylation sequencing and diagnose cancer through big data and deep learning methods.
Study of the changes of epigenetics in various diseases, by providing biologists and doctors with biological information data analysis. The main topics are data mining of animal mechanism experiments and sequencing data mining of human heart disease, cancer, and infection samples.
Study of epigenetic changes in stem cell differentiation and aging. We mainly use mouse models or cell lines to study the methylation of stem cells or differentiation in the aging system or developmental system, histone and transcriptome including LncRNA and miRNA changes to study the relationship between natural aging and cancer and the mechanism of progeria.
Research on algorithms related to epigenetic genome data and develop related software and databases.