Du Yushen, M.D., Ph.D.

Department: Cancer Insititute

Medical School: University of California, Los Angeles

                            Zhejiang University, Zhejiang, China

Academic Rank: Associate Chief Professor

Clinical / Research Interests

Quantitative High-throughput Genomics:

Developed a quantitative and high-throughput genetics system for RNA viruses, including influenza virus, HIV, HCV and Zika virus.

Established a systematic method to identify and annotate functional residues of a given viral protein.

Established an influenza HIS vaccine strain by combining IFN sensitive mutations across the entire viral genome. 

Examined the safety and efficacy of HIS vaccine in mouse and ferret models.


Protein Interactome:

Established exon/cDNA library-based mRNA display-deep sequencing platform for studying protein-protein interactome or drug-protein interactions, with high sensitivity and accuracy.

Examined influenza viral-host interactome by coupling mRNA display platform with Mass Spectrometry.

Determined the cellular interacting partner of a Chinese medicine derived small chemical: martynoside; and studied the mechanism of it facilitating hematopoiesis.



Professional Highlights

Yong CJ scholar Award, 2021

National Scholarship (Graduate Student, Top 1%) Zhejiang University, 2018

UCLA Dissertation Year Award UCLA, 2017

Whitcome Pre-doctoral training program fellowship UCLA, 2015 - 2016

UCLA Graduate Fellowship UCLA, 2013

Provincial Outstanding Graduate Zhejiang University, 2011

Zhejiang University Outstanding Graduate Zhejiang University, 2011

Top hundred Premium Undergraduate Thesis Zhejiang University, 2011

Excellent Academic Performance Scholarship Zhejiang University, 2009 - 2010

National Scholarship (Undergraduate, Top 1%) Zhejiang University, 2008


Professional Appointments

Education Experience

Research Summary

Publications

Du Y, Xin L, Shi Y, Zhang TH, Wu NC, Dai L, Gong D, Brar P, Shu S, Reiley W, Luo J, Reiley W, Tseng YW, Bai H, Wu TT, Wang J, Shu Y, Sun R. Genome-wide identification of anti-interferon functions in influenza A virus enabling rational vaccine design. Science, 2018, Jan 19, http://science.sciencemag.org/content/359/6373/290

Du Y, Hultquist JF, Zhou Q, Olson A, Tseng YW, Zhang TH, Hong MY, Tang KJ, Chen LB, Meng XZ, McGregor MJ, Gong DY, Martin-Sancho L, Chanda S, Li XM, Bensenger S, Krogan NJ, Sun R. mRNA display with library of even-distribution (md-LED) reveals cellular interactors of influenza virus NS1. Nature Communications,2020, 11(1). 1-13. https://www.nature.com/articles/s41467-020-16140-9

Marsden MD*, Zhang TH*, Du Y*, Dimapasoc M, Wu X, Kim JT, Shimizu A, Schrier A, Wender PA, Sun R, Zack JA, Barcoded HIV reveals effects of PKC modulation on viral reservoir, Cell Reports Medicine, Accepted.  *Equal contributions.

Du Y, Wu NC, Zhang TH, Gong DY, Shu S, Wu T-T, Sun R. Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis. mBio, 2016, 7(6), e01801-16., https://mbio.asm.org/content/7/6/e01801-16

Du Y*, Zhang TH*,Dai L*, Zheng X*, Gorin A, Oishi J, Wu TT, Yoshizawa J, Li Xin, Yang O, Martinez-Maza O, Detels R, Sun R. CTL escape of HIV-1 Gag epitopes is determined by mutational effects on replicative fitness and MHC-1 binding. mBio , 2017, 8(6),e01050-17, https://mbio.asm.org/content/8/6/e01050-17

Wu NC*, Du Y*, Le S, Young AP, Zhang T-H, Wang Y, Zhou J, Yoshizawa JM, Dong L, Li X, others. Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment. BMC Genomics. BioMed Central; 2016; 17(1):1.   *Equal contributions.

Du Y*, Chi X *, Wang C, Jiang J, Kong F, Yan H, Wang X, Wu NC, Dai L, Zhang TH, Bhattacharya D, ,Niu J, Sun R. Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing.  Scientific Reports 7 (2017)

Du, Y., Sun, R., Hong, M., Tang, K., Qian, J., Deng, H., Zeng, M., Zheng, S. and Ding, K., Immunotherapy for EBV-associated Nasopharyngeal Carcinoma. Critical Reviews? in Oncogenesis, 2018.

 


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