Ge Yun, M.D.

DepartmentGeneral ICU

Medical SchoolZhejiang University School of Medicine, China

Academic RankAssociate Chief Physician


Clinical / Research Interests

Sepsis, shock, multiple organ dysfunction

Professional Highlights

Advanced worker, Zhejiang University School of Medicine, 2020

Advanced worker, Zhejiang University, 2020


Professional Appointments

Youth Member, Chinese Research Hospital Association

Member, Zhejiang Society of Mathematical Medicine

Education Experience

Doctor's Degree, Zhejiang University School of Medicine, 2019-2022

Master's Degree, Wenzhou Medical University, 2009-2012

Bachelor's Degree, Wenzhou Medical University, 2003-2008


Research Summary


Yun Ge, Juan Chen, Yanting Hu, Xinyi Chen, Man Huang. IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome. Mediators of Inflammation. 2021, 2021, 2021:6370911.

Yun Ge, Man Huang*, Yong-ming Yao*. The effect and its regulatory mechanism of high mobility group box-1 protein on immune cells in inflammatory diseases. cells. 2021, 10, 1044.

Yun Ge#, Man Huang#, Yong-ming Yao*. Biology of interleukin-17 and its pathophysiological significance in sepsis. Frontiers in immunology. 2020, 28;11:1558.  

Yun Ge, Man Huang*, Ning Dong, Yong-ming Yao*. Interleukin-36β   activates autophagy of CD4+CD25+ regulatory T cells and inhibits its immunosuppressive activity in sepsis. Journal of infectious diseases. 2020, 222 (8), 1517-1530.  

Yun Ge#, Man Huang#, Yao Wu, Ning Dong, Yong-ming Yao*. Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+CD25+regulatory T cells. Journal of Cellular and Molecular Medicine. 2020, 24: 2027-2039.

Yun Ge, Man Huang#, Yong-ming Yao*. Immunomodulation of interleukin-34 and its potential significance as a disease biomarker and therapeutic target. International Journal of Biological Sciences, 2019, 15(9): 1835-1845.

Yun Ge, Xin Xu, Qi-qiang Liang, Yong-shan Xu, Man Huang*.α-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice. Inflammation Research, 2019, 68(6): 471-479.

Yun Ge, Man Huang#, Xiao-mei Zhu, Yong-ming Yao*. Biological functions and clinical implications of interleukin-34 in inflammatory diseases. Advances in protein chemistry and structrual biology, 2020, 119.

Yun Ge, Man Huang#, Yong-ming Yao*. Recent advances in the biology of IL-1 family cytokines and their potential roles in development of sepsis. Cytokine & Growth Factor Reviews, 2019, 45:24-34.  

Yun Ge, Man Huang, Yong-ming Yao*. Autophagy and proinflammatory cytokines: Interactions and clinical   implications. Cytokine & Growth Factor Reviews, 2018, 43:38-46.

Yun Ge, Zhijun Xu, Yanting Hu, Man Huang*. Successful voriconazole treatment of Talaromyces marneffei infection in an HIV-negative patient with osteolytic lesions. Journal of Infection   Chemotherapy, 2019, 25: 204-207.

Yun Ge, Man Huang, Yue-feng Ma*. The effects of microRNA-34a regulating Notch-1/NF-κB signaling pathway on LPS-induced HUVEC, World Journal of Emergency Medicine, 2017, 8: 47-51.


Current Program

The potential role of PD-1/PD-L1 signaling induced by IL-38 in regulatory T cells dysfunction in sepsis. Funding Source: National Natural Science Foundation of China (81974293), 2020-2023.

The potential role of NLRP3 inflammasome induced by α?Mangostin in sepsis. Funding Source: Zhejiang Province Medicine and Health Science and Technology Program (2021KY710), 2020-2022.


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