Zhang Zhigang, M.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician 


Clinical / Research Interests

Surgical and precision treatment of gynecological oncology;

Immune mechanism and clinical transformation of ovarian cancer recurrence and metastasis.

Professional Highlights

Professional Appointments

Secretary and Vice Chairman, Youth Committee, Clinical Epidemiology and Evidence-Based Medicine Branch, Zhejiang Medical Association

Member, Youth Committee of Gynecological Oncology Branch, Zhejiang Medical Association

Education Experience

Research Summary


Zhigang Zhang#; Chenghui Yang#; Lili Li; Ying Zhu; Ke Su; Lingyun Zhai; Zhen Wang*; Jian Huang*. "γδT cell-IL17A-neutrophil" axis drives immunosuppression and confers breast cancer resistance to high-dose  anti-VEGFR2 therapy, Frontiersin Immunology, 2021, 12:699478.(IF:7.56)

Chenghui Yang#; Zhen Wang# ;Lili  Li#; Zhigang Zhang; Xiaoyan Jin; Pin Wu; Shanshan Sun; Jun Pan; Ke Su; Fang Jia; Leyi Zhang; Haijun Wang; Xiuyan Yu; Xuan Shao; Ke Wang; Fuming Qiu; Jun Yan; Jian Huang*. Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis, Journal for ImmunoTherapy of Cancer, 2021, 9(10): e002875.(IF:13.75)

Zhigang Zhang#;  Weilan Wang#; Xiaochen Wang;  Xiuyan Yu; Ying Zhu; Hongwei Zhan; Zhigang Chen; Baizhou Li; Jian Huang*;  Breast-specific gammaimaging or ultrasonography as adjunct imaging   diagnostics in women with mammographically dense breasts, European Radiology, 2020, 30(11):  6062-6071.(IF:5.32)

Ying Zhu#; Zhigang  Zhang#;  Zhou Jiang;  Yang  Liu; Jianwei  Zhou*;  CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment, Frontiers in Genetics, 2020, 11: 0-369. (IF:3.26)

Zhigang Zhang#; Ying Zhu#; Zhen Wang#; Ting Zhang; Pin Wu; Jian Huang*; Yin-yang effect of tumor infiltrating B cells in breast cancer: From mechanism to immunotherapy, Cancer Letters, 2017, 393: 1-7. (IF:8.68)

Current Program

The role of epirubicin induces B cells express Fas-Ligand in microenvironment of breast cancer and related mechanisms. Funding Source: Natural Science Foundation of Zhejiang.

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