Chai Ying, B.S. Med

Position:Honorary Chair of Thoracic Surgery

Department:Thoracic Surgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician, Doctoral Supervisor


Clinical / Research Interests

Basic and clinical research on lung cancer and esophageal cancer;

Research on pathogenesis and treatment of mediastinal tumor and sternal tumor;

Research on mechanism and treatment strategies for thoracic trauma;

Research on pathogenesis and surgery of myasthenia gravis;

Research on methodology of thoracic surgery.

Professional Highlights

Zhejiang Scientific and Technological Progresss Award, First, Second and Third prize.

Professional Appointments

Member, Standing Committee, Thoracic Society, Chinese Medical Doctor Association

Vice Chairman, National Expert committee of Trauma Surgery, Chinese Medical Doctor Association

Deputy Director, Working Team of Zhejiang Province, Thoracic Society, Chinese Medical Doctor Association

Member,  Standing Committee, Thoracic Branch of Endoscopic and Minimally Invasive Professional and Technical Evaluation Committee , Chinese Medical Doctor Association.

Member, Standing Committee, Thoracic Branch of World Endoscopy Doctors Association

Member, Standing Committee, International Chinese Society of Thoracic Surgery

Member, Standing Committee, Zhejiang Anti-Cancer Association

Vice Chairman, Specialized Committee, Lung Cancer Society, Zhejiang Anti-Cancer Association

Member, Standing Committee, Esophageal Cancer Society, Zhejiang Anti-Cancer Association

Vice Chairman, Specialized Committee of Tumor, Zhejiang Association of Integrative Medicine

Member, Specialized Committee, Zhejiang Thoracic Society

Member, Zhejiang Association of Integrative Medicine

Member, Zhejiang Specialized Association of Authentications of Medical Accidents

Vice Chairman, Faculty Board of Cardiothoracic Surgery, Zhejiang University School of Medicine

Education Experience

Research Summary

Basic and clinical research on lung cancer; operative treatment of rib tumor and sternal tumor; clinical research on mediastinal tumor; clinical research on esophageal cancer.


Adult Bochdalek hernia complicated with a perforated colon. J Thorac Cardiovasc Surg 2005, 130:1729-1730.

Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report. Chin Med J (Engl). 2002;115(11):1743-4.

Peripheral primitive neuroectodermal tumour of left ventricular wall origin: a rare case. Acta Cardiol 2007, 62:523-524.
Autogenous rib grafts for reconstruction of sternal defects after partial resection: a new surgical technique. Plast Reconstr Surg 2008, 121:353e-355e.

Spontaneous pneumomediastinum in adolescents. Chin Med J (Engl) 2007, 120:2329-2330.

A giant solitary fibrous tumor of the pleura. Chin Med J (Engl) 2013, 126:2999.

Giant fibrous tumours of the pleura with mucus secretion. Niger J Clin Pract 2013, 16:260-262. 

Autogenous rib graft for reconstruction of sternal defects. J Thorac Dis 2014, 6:1851-1852.

An ectopic hamartomatous thymoma compressing left jugular vein. Niger J Clin Pract 2014, 17:814-816.

Single-position, minimally invasive Ivor Lewis oesophagectomy for lower thoracic oesophageal cancer. Eur J Cardiothorac Surg 2014, 46:1032-1034.

Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx. Exp Biol Med (Maywood) 2014, 239:1653-1662.

Autogenous rib grafts for reconstruction of the manubrium after resection: technical refinements and outcomes. J Thorac Cardiovasc Surg 2014, 148:2667-2672.

Histoplasmosis presenting with solitary pulmonary nodule: two cases mimicking pulmonary metastases. Niger J Clin Pract 2015, 18:304-306.

A rare desmoid tumor arising from the manubrium. J Cardiothorac Surg 2015, 10:33.

Pulmonary resection and systemic lymph node dissection in a patient with breast cancer who had a 33-year disease-free interval. World J Surg Oncol 2015, 13:150.

PD-L1 and Survival in Solid Tumors: A Meta-Analysis. PLoS One 2015, 10:e0131403.

Minimally invasive esophageal resection and intrathoracic anastomosis for lower thoracic esophageal cancer with single position. J Thorac Dis 2015, 7:1486-1488.

Vanishing lung syndrome of uncommon size. Am J Med Sci 2015, 349:e2.

Novel Strategy for Synchronous Multiple Primary Lung Cancer Displaying Unique Molecular Profiles. Ann Thorac Surg 2016, 101:e45-47.

Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis. Onco Targets Ther 2016, 9:6605-6608.

Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis. Oncotarget 2016, 7:19863-19883.

Delayed iatrogenic diaphragmatic hernia after thoracoscopic lobectomy. J Thorac Dis 2016, 8:E399-402.

Giant mediastinal schwannoma located in the lower right side of the chest. Niger J Clin Pract. 2016;19(5):678-80.

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis. Oncotarget 2016, 7:40451-40460.

Vanishing Lung Syndrome With Air-Fluid Levels. Am J Med Sci 2016, 352:e1.

Complete remission of liver metastasis in a lung cancer patient with epidermal growth factor mutation achieved with Icotinib. Thorac Cancer 2016, 7:681-683.

Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles. Oncotarget 2016, 7:81969-81971.

Left bronchial isomerism in a lung cancer patient undergoing right upper pulmonary lobectomy via a thoracoscope. Thorac Cancer 2017, 8:54-56.

Systematic review of CYFRA 21-1 as a prognostic indicator and its predictive correlation with clinicopathological features in Non-small Cell Lung Cancer: A meta-analysis. Oncotarget. 2017,17;8(3):4043-4050.

Prognostic role of cyclin B1 in solid tumors: a meta-analysis. Oncotarget 2017, 8:2224-2232.

Risk factors of lymph node metastasis in lung squamous cell carcinoma of 3 cm or less in diameter. Medicine (Baltimore) 2017, 96:e7563.

Omental herniation through the diaphragmatic defect: Two cases mimicking mediastinal lipomas. Niger J Clin Pract. 2017;20(8):1044-1045.

Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report. Medicine (Baltimore) 2017, 96:e7870.

The addition of apatinib to gefitinib or icotinib for advanced non-small cell lung cancer with acquired resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitor: An assessment of effectiveness and safety. ANN ONCOL. 2017, (Meeting Abstract).

Improved Closure Technique for Uniportal Video-Assisted Thoracic Surgery: Double-Embedding Stitching Method. Ann Thorac Surg 2017, 104:1760-1761.

Crizotinib resistance overcome by ceritinib in an ALK-positive non-small cell lung cancer patient with brain metastases: A case report. Medicine (Baltimore) 2017, 96:e8652.

Tonsillar metastasis of nonsmall cell lung cancer with G719S mutation in exon 18: A case report. Medicine (Baltimore) 2017, 96:e9003.

Retrospective study on video-assisted vs. open mediastinal lymphadenectomy for non-small cell lung cancer: a propensity-matched analysis. J Thorac Dis 2018, 10:1884-1890.

Histologic transformation from adenocarcinoma to both small cell lung cancer and squamous cell carcinoma after treatment with gefitinib: A case report. Medicine (Baltimore). 2018 ;97(18):e0650.

Staging resection of multiple primary esophageal cancer by endoscopic submucosal dissection and esophagectomy: A case report. Medicine (Baltimore) 2018, 97:e0657.

Pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymph tissue: A case report and literature review. Niger J Clin Pract. 2018;21(3):392-394.

Reduced complexity of uniportal video-assisted thoracoscopic left upper sleeve lobectomy. J Thorac Dis 2018, 10:3791-3796.

Prognostic role of targeting protein for Xklp2 in solid tumors: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2018, 97:e13018.

Novel T-Shaped Linear-Stapled Intrathoracic Esophagogastric Anastomosis With a Little Improvement. Ann Thorac Surg 2018, 106:939-940.

Effective treatment of advanced alveolar soft part sarcoma with sunitinib: A case report. Medicine (Baltimore) 2018, 97:e13584.

Combined Ectopic Variation of the Right Upper Pulmonary Vein and Bronchus. Ann Thorac Surg. 2020, 109(5):e353-e355.

CD8(+) T Cells Form the Predominant Subset of NKG2A(+) Cells in Human Lung Cancer. Front Immunol 2019, 10:3002.

Prognostic role of targeting protein for Xklp2 in solid tumors: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2018, 97:e13018.

Current Program

Function and mechanism of long non-coding RNA such as CYB2B in lung adenocarcinoma. Funding Source: Natural Science Foundation of Zhejiang Province.

Canonical diagnosis and treatment for early stage small peripheral lung cancer. Funding Source: Zhejiang Provincial Department of Science and Technology.

Expression of RON in early lung adenocarcinoma and its relationship with prognosis and pathological stage. Funding Source: Zhejiang Provincial Department of Science and Technology.

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