Xu Yinchuan, M.D., Ph.D.

DepartmentCardiology

Medical SchoolZhejiang University School of Medicine, China

Academic RankAssociate Chief Physician

Appointment

Clinical / Research Interests

Professional Highlights

Professional Appointments

Education Experience

Visiting Scholar, Joseph C Wu's LabStanford University, Palo Alto, U.S.A, 2019-2020

Visiting Scholar, Jianyi (Jay) Zhang's Lab, University of Minnesota, Minnesota, U.S.A 2014

Visiting Scholar, Alan Daugherty's Lab, Saha Cardiovascular Research Center, University of Kentucky, Lexington, U.S.A, 2012-2013

Ph.D. in Cardiovascular Medicine, Zhejiang University School of Medicine, China, 2009-2014

M.D, Wenzhou Medical University, China, 2004-2009


Research Summary

Publications

Rong J, Tao X, Lin Y, Zheng H, Ning L, Lu HS, Daugherty A, Shi P, Mullick AE, Chen S, Zhang Z, Xu Y, Wang J. Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction. Circ Res.2021;129(5):547-564. (Co-Corresponding Author)

Li Q, Xu Y, Lv K, Wang Y, Zhong Z, Xiao C, Zhu K, Ni C, Wang K, Kong M, Li X, Fan Y, Zhang F, Chen Q, Li Y, Li Q, Liu C, Zhu J, Zhong S, Wang J, Chen Y, Zhao J, Zhu D, Wu R, Chen J, Zhu W, Yu H, Ardehali R, Zhang JJ, Wang J, Hu X. Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates. Sci Transl Med. 2021;13(584):eabb0202. (Co-First Author)

Xu Y, Rong J, Zhang Z. The emerging role of angiotensinogen in cardiovascular diseases. J Cell Physiol. 2021;236(1):68-78.

Ning L, Rong J, Zhang Z, Xu Y. Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications. Pharmacol Res. 2021;167:105409.

Zheng HQ, Rong JB, Ye FM, Xu YC, Lu HS, Wang JA. Induction of thoracic aortic dissection: a mini-review of β -aminopropionitrile-related mouse models. J Zhejiang Univ Sci B. 2020;21(8):603-610.

Chen FC, Xu YC, Zhang ZC. Multi-biomarker strategy for prediction of myocardial dysfunction and mortality in sepsis. J Zhejiang Univ Sci B. 2020 Jul;21(7):537-548. (Co-Corresponding Author)

Xu Y, Zhang S, Rong J, Lin Y, Du L, Wang Y, Zhang Z. Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle. Pharmacol Res. 2020;159:104887.

Lin Y, Xu Y, Zhang Z. Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria. Inflammation. 2020;43(4):1184-1200. (Co-First Author)

Tao XR, Rong JB, Lu HS, Daugherty A, Shi P, Ke CL, Zhang ZC, Xu YC, Wang JA. Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. J Lipid Res. 2019;60(12):1983-1995. (Co-Corresponding Author)

Wang Y, Xu Y, Wu C, Xia H, Wang Y, Nan J, Chen J, Yu H, Zhu W, Shi P, Daugherty A, Lu HS, Wang J. One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm. Biosci Rep. 2019 May 3;39(5):BSR20182055

Current Program

Elucidating The Effect and Mechanism of Cardiac Fibroblastic LRP1-Dependent Endocytosis of Liver Angiotensinogen on Sepsis induced Myocardial Dysfunction. Funding Source: National Natural Science Foundation of China, 2020-2023.

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