Zhang Baorong, M.D.

Position:Chair of Neurology


Medical School:Kiel University, Germany

Academic Rank:Professor, Chief Physician


Clinical / Research Interests

Genetics and mechanisms study, clinical trial research of neurodegenerative disease, especially on Parkinson's disease, Alzheimer's and Huntington's diseases.

Professional Highlights

Outstanding Dedication, International Parkinson and Movement Disorder Society, 2017

"China Outstanding Neurologist" Academic Achievement Award, 2019

Professional Appointments

Executive Committee Member, International Parkinson and Movement Disorder Society Asian and Oceanian Section, 2013-2017

Treasure Officer, International Parkinson and Movement Disorder Society Asian and Oceanian Section, 2017-2019  

Standing Committee Member, Neurology Branch, Chinese Medical Association

President, Zhejiang Society of Neurology

Education Experience

Research Summary

Dr. Zhang's research centers around early diagnosis, molecular mechanism, and treatment of Parkinson's disease, Alzheimer's disease and Huntington's disease. He is also an expert in genetic counseling of inherited neurological disorders. He established iPSC models of Parkinson's disease and healthy controls to study phenotype-genotype associations. His research into the biomarker screening of Alzheimer's disease has significant implications for the early diagnosis and treatment of the disease.


R Wenzelburger, Zhang BR, S Pohle, S Klebe, D Lorenz, J Herzog,H Wilms,G Deuschl,P Krack. Force overflow and levodopa-induced dyskinesias in Parkinson’s disease. Brain, 2002, 125:871-879.

Wenzelburger R, Zhang BR, M Poepping, B Schrade, D Weinte, F Kopper, U Fietek, H M, M, G Deuschl, P Krack. Dyskinesias and grip control in Parkinson’s disease are normalized by chronic stimulation of the subthalamic nucleus. Ann Neurol, 2002,52(2):240-243. 

R Wenzelburger, F Kopper, Zhang BR, K Witte, W Hamel, D Weinter, J Kuhtz-buschbeck, M Golge, M Illert, G Deuschl, P Krack. Subthalamic nucleus stimulation for Parkinson’s disease preferentially improves akinesia of proximal arm movements compared to finger movement. Move Dis, 2003, 18(10): 1162-1169. 

Zhang BR, Yin XZ, Xia K, Ding MP, Hu ZM, Zheng M, Liu ZR, Xia JH. Mutation analysis of keratin 9 gene in a pedigree with epidermolytic palmoplantar keratoderma. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Dec; 21(6):570-3. Chinese.

Zhang BR*, X Kun, Ding M, D Liang, Z Liu, Q Pan, Z Hu, L Wu, F Cai, JH Xia. Confirmation and refinement of a genetic locus of congenital motor nystagmus in Xq26.3-q27.1 in a Chinese family. Hum Genet, 2005, 116:128-131. 

Zhang BR, Song F, Yin XZ, Xia K, Tian J, Huang JZ, Xia JH. IT15 gene analysis in two pedigrees of Huntington's disease. Yi Chuan. 2006 Nov;28(11):1345-9. Chinese.

Yin XZ, Zhang BR, Wu DW, Tian J, Zhang H.The clinical features and gene mutation analysis in a pedigree of spinocerebellar ataxia type 7. Yi Chuan. 2007 Jun;29(6):688-92. Chinese.

Yin XZ, Zhang BR, Ding MP, Zhang H, Xia K, Hu ZM. Pathological features and gene mutation analysis in two pedigrees of diffuse palmoplantar keratoderma. Yi Chuan. 2007 Mar; 29(3):301-5. Chinese.

Zhang BR*, Liu ZR, Zhao GH, et al. Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus. Mol Vis, 2007, 13:1674-9 

Zhang BR*, Tian J, Yin XZ, Luo W, Xia K. The protective effect of sodium butyrate on the cell culture model of Huntington disease. Progress in Nature Science. 2007; 17(7): 784-788.

Zhao G, Ding M, Zhang BR* et al.Clinical manifestations and management of acute thallium poisoning.Eur Neurol. 2008;60(6):292. 22. Luo W, Ouyang Z, Xu H, Chen J, Ding M, Zhang B.The clinical analysis of general paresis with 5 cases. J Neuropsychiatry Clin Neurosci. 2008; 20(4):490-3.

Liu Z, Ding Y, Du A, Zhang B, Zhao G, Ding M. A novel Twinkle (PEO1) gene mutation in a Chinese family with adPEO. Mol Vis. 2008;14:1995-2001. 

Zhao G, Ding M, Zhang B, Lv W, Yin H, Zhang L, Ying Z, Zhang Q. Clinical manifestations and management of acute thallium poisoning. Eur Neurol. 2008;60(6):292-7. 

Yin XZ, Ding MP, Zhang BR, Liu JR, Zhang L, Wang PZ, Zhou FY, Zhao GH. Report of two Chinese families and a review of Mainland Chinese CADASIL patients. J Neurol Sci. 2009 Apr 15;279(1-2):88-92. 

Zhang BR*, Hu ZX, Yin XZ, Cai M, Zhao GH, Liu ZR, Luo W.Mutation analysis of parkin and PINK1 genes in early-onset Parkinson's disease in China. Neurosci Lett. 2010, 23(4).19. 

Ding Y, Wang S, Liu J, Yang Y, Liu Z, Li J, Zhang B, Chen Y, Ding M. Neuropsychiatric profiles of patients with insulinomas. Eur Neurol. 2010; 63(1):48-51.

Luo W, Gui XH, Wang B, Zhang WY, Ouyang ZY, Guo Y, Zhang BR, Ding MP. Validity and reliability testing of the Chinese (mainland) version of the 39-item Parkinson's Disease Questionnaire (PDQ-39). J Zhejiang Univ Sci B. 2010 Jul;11(7):531-8.

Hu ZX, Peng DT, Cai M, Pu JL, Lei XG, Yin XZ, Ou-Yang ZY, Luo W, Zhang BR*.A study of six point mutation analysis of LRRK2 gene in Chinese mainland patients with Parkinson‘s disease. Neurol Sci. 2011 Aug;32(4):741-2. 

Pu J, Li Y, Liu Z, Yan Y, Tian J, Chen S, Zhang B*. Expression and localization of FRMD7 in human fetal brain, and a role for F-actin. Mol Vis. 2011; 17: 591-597. 

Yan YP, Mo XY, Tian J, Zhao GH, Yin XZ, Jin FY, Zhang BR*. An association between the PARK16 locus and Parkinson's disease in a cohort from eastern China. Parkinsonism Relat Disord. 2011 Dec;17(10):737-9. 

Yan YP, Peng DT, Tian J, Chi JW, Tan JQ, Yin XZ, Pu JL, Xia K, Zhang BR*. The essential sequence of the N-terminal cytoplasmic localization related domain of huntingtin and its effect on the aggregate. Science China, 2011; 54 (4): 1-9. 

Cai M, Tian J, Zhao GH, Luo W, Zhang BR*. Study of methylation levels of parkin gene promoter in Parkinson's disease patients. Int J Neurosci. 2011 Sep;121(9):497-502.

Yan Y, Tian J, Mo X, Zhao G, Yin X, Pu J, Zhang B*. Genetic variants in the RAB7L1 and SLC41A1 genes of the PARK16 locus in Chinese Parkinson's disease patients. Int J Neurosci. 2011 Nov; 121 (11): 632-6.

Li Y, Pu J, Liu Z, Xu S, Jin F, Zhu L, Tian J, Luo J, Zhang B*. Identification of a novel FRMD7 splice variant and functional analysis of two FRMD7 transcripts during human NT2 cell differentiation. Mol Vis. 2011;17:2986-96. 

Ou-Yang ZY, Song SJ, Liu JR, Zhang BR, Wu DW. Clinical and genetic analysis of a pedigree of Kennedy disease. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Sep; 40(5):555-8. Chinese.

Zhang BR*, Tian J, Yan YP, Yin XZ, Zhao GH, Wu ZY, Xia K, Tang BS.  CCG repeat in huntingtin gene among mainland Chinese HD families and effect of the proline-rich regions on aggregate. J Neurol Sci. 2012 Jan 15; 312(1-2):92-6. 

Y Ren, X Liu, S Lesage, M Cai, J Pu, B Zhang, A Brice, J Feng. The Normal Parkin Sequence. Mov Dis 2012 Mar;27(3):463-4.

Pu J, Lu X, Zhao G, Yan Y, Tian J, Zhang B*. FERM domain containing protein 7 (FRMD7) upregulates the expression of neuronal cytoskeletal proteins and promotes neurite outgrowth in Neuro-2a cells. Mol Vis. 2012; 18:1428-35. 

Pu J, Jiang H, Zhang B, Feng J.Redefining Parkinson's disease research using induced pluripotent stem cells. Curr Neurol Neurosci Rep. 2012 Aug; 12(4):392-8.

Pu J, Mao Y, Lei X, Yan Y, Lu X, Tian J, Yin X, Zhao G, Zhang B*.FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling. PLoS One. 2013; 8(8):e73108.

Li Y, Pu J, Zhang B*. Expression of a novel splice variant of FRMD7 in developing human fetal brains that is upregulated upon the differentiation of NT2 cells. Exp Ther Med. 2014 Oct;8(4):1131-1136.

Yin X, Wu D, Wan J, Yan S, Lou M, Zhao G, Zhang B*. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: Phenotypic and mutational spectrum in patients from mainland China. Int J Neurosci. 2014 Sep 1. [Epub ahead of print]

Mao YF, Guo ZY, Pu JL, Chen YX, Zhang B*. Association of CD33 and MS4A cluster variants with Alzheimer's disease in East Asian populations. Neurosci Lett. 2015;609:235-9. 

Lei X, Li H, Huang B, Rizak J, Li L, Xu L, Liu L, Wu J, Lü L, Wang Z, Hu Y, Le W, Deng X, Li J, Yao Y, Xu L, Hu X, Zhang B*.1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PLoS One. 2015;10(5):e0127953.

Zheng T, Lv Q, Lei X, Yin X, Zhang B*. Spatial distribution of 5-hydroxymethyl cytosine in rat brain and temporal distribution in striatum. Neurochem Res. 2015;40(4):688-97. 

Lei X, Huang B, Li H, Jiang H, Hu X, Zhang B*. Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis.Neuroscience. 2015;299:107-24. 

R Ye, TShen, Y Jiang, L Xu, X Si, B Zhang*. The Relationship between Parkinson Disease and Brain Tumor: A Meta-Analysis. PLOS ONE.2016 October. 

Amy K Y Fu, Kwok-Wang Hung, Michael Y F Yuen, Xiaopu Zhou, Deejay S Y Mak, Ivy C W Chan, Tom H Cheung, Baorong Zhang, Wing-Yu Fu, Foo Y Liew, Nancy Y Ip *.IL-33 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Decline. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2705-13. 

T Shen, J Pu, X Si, R Ye, B Zhang*. An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms. Expert Rev Neurother. 2016;16(6):711-22. 

Mao YF, Guo Z, Zheng T, Jiang Y, Yan Y, Yin X, Chen Y, Zhang B*.Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice. Aging Cell. 2016 Jul 26. doi: 10.1111/acel.12498.

Guo Z, Chen Y, Mao YF, Zheng T, Jiang Y, Yan Y, Yin X, Zhang B*. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Sci Rep. 2017;7:45971. 

Chen Y, Dai CL, Wu Z, Iqbal K, Liu F, Zhang B*, Gong CX. Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes. Front Aging Neurosci. 2017;9:136. 

Zheng T, Pu J, Chen Y, Mao Y, Guo Z, Pan H, Zhang L, Zhang H, Sun B, Zhang B*. Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer's Disease. Front Aging Neurosci. 2017 ;9:12.

T Shen, R Ye, B Zhang*. Efficacy and safety of pramipexole extended-release in Parkinson's disease: a review based on meta-analysis of randomized controlled trials. Eur J Neurol. 2017 Jun;24(6):835-843. 

Zheng T, Pu J, Chen Y, Guo Z, Pan H, Zhang L, Zhang H, Sun B, Zhang B*. Exosomes Secreted from HEK293-APP Swe/Ind Cells Impair the Hippocampal Neurogenesis. Neurotox Res. 2017;32(1):82-93.

Zhao Chen,Chunrong Wang, Caifa Zheng, Zhe Long, Li Cao, Xunhua Li, Huifang Shang, Xinzhen Yin, Baorong Zhang, Jingyu Liu, Dongxue Ding,Yun Peng, Huirong Peng, Wei Ye, Rong Qiu, Qian Pan, Kun Xia, Shengdi Chen, Jorge Sequeiros, Tetsuo Ashizawa, Beisha Tang, and Hong Jiang, on behalf of the Chinese Clinical Research Cooperative Group for Spinocerebellar Ataxias (CCRCG-SCA).Ubiquitin-related network underlain by (CAG)n loci modulate age at onset in Machado-Joseph disease.BRAIN 2017: 140; 1–5.

Zheng T, Wu X, Wei X, Wang M, Zhang B*. The release and transmission of amyloid precursor protein via exosomes. Neurochem Int. 2018;114:18-25. 

Yan YP, Zhang B, Shen T, Si XL, Guo ZY, Tian J, Xu CY, Zhang BR*. Study of GCH1 and TH genes in Chinese patients with Parkinson's disease. Neurobiol Aging. 2018;68:159.e3-159.e6. 

Shen T, Pu J, Lai HY, Xu L, Si X, Yan Y, Jiang Y, Zhang B*. Genetic analysis of ATP13A2, PLA2G6 and FBXO7 in a cohort of Chinese patients with early-onset Parkinson's disease. Sci Rep. 2018;8(1):14028. 

Tian J, Yan Y, Xi W, Zhou R, Lou H, Duan S, Chen JF, Zhang B*. Optogenetic Stimulation of GABAergic Neurons in the Globus Pallidus Produces Hyperkinesia. Front Behav Neurosci. 2018;12:185. 

Hu Q, Li H, Tian J, Zhang B*. Bulbar paralysis associated with Miller-Fisher syndrome and its overlaps in Chinese patients. Neurol Sci. 2018;39(2):305-311. 

Si X, Tian J, Chen Y, Yan Y, Pu J, Zhang B*. Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease. Neuroscience. 2019; 413:308-316. 

Shen T, Zhao S, Jiang Y, Pu J, Lai HY, Yan Y, Tian J, Chen Y, Zhang B*. Haplotype Analysis on the Relationship of the DNAJC6 Gene with Early-Onset Parkinson's Disease Risk in a Chinese Population. J Parkinsons Dis. 2019;9(1):109-120. 

Pu J, Dai S, Gao T, Hu J, Fang Y, Zheng R, Jin C, Zhang B*. Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons. Brain Behav. 2019;9(12):e01473. 

Xiaojun Guan, Tao Guo, Qiaoling Zeng, Jiaqiu Wang, Cheng Zhou, Chunlei Liu, Hongjiang Wei,Yuyao Zhang, Min Xuan, Quanquan Gu, Xiaojun Xu*, Peiyu Huang, Jiali Pu, Baorong Zhang and Min-Ming Zhang*.Oscillation-specific nodal alterations in early to middle stages Parkinson’s disease. Translational Neurodegeneration. (2019) 8:36

Xu L, Chen Y, Shen T, Lin C, Zhang B. Genetic Analysis of PICK1 Gene in Alzheimer's Disease: A Study for Finding a New Gene Target. Front Neurol. 2019;9:1169.

Zhidong Cen, You Chen, Dehao Yang, Qingchen Zhu, Si Chen, Xinhui Chen, Bo Wang, Fei Xie, Zhiyuan Ouyang, Zhengwen Jiang, Aisi Fu, Ben Hu, Houmin Yin, Xia Qiu, Feng Yu, Xiaoping Du, Weicheng Hao, Yuxi Liu, Haotian Wang, Lebo Wang,Xiafei Yu, Yichuan Xiao, Chunyu Liu, Jianfeng Xiao, Yongxing Zhou, Wei Yang, Baorong Zhang and Wei Luo *.Intronic (TTTGA)n Insertionin SAMD12 Also Causes FamilialCortical Myoclonic Tremor With Epilepsy.Mov Disord. 2019 Oct;34(10):1571-1576. 

Lin C, Zhao S, Zhu Y, Fan Z, Wang J, Zhang B, Chen Y*. Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease. Comput Struct Biotechnol J. 2019;17:1309-1317. 

Gao T, Wu J, Zheng R, Fang Y, Jin CY, Ruan Y, Cao J, Tian J, Pu JL, Zhang BR*. Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China. CNS Neurosci Ther. 2020; 26(4):448-452. 

Yue Y, Jiang Y, Shen T, Pu J, Lai HY, Zhang B*. ALFF and ReHo Mapping Reveals Different Functional Patterns in Early- and Late-Onset Parkinson's Disease. Front Neurosci. 2020;14:141. 

Pu J, Gao T, Zheng R, Fang Y, Ruan Y, Jin C, Shen T, Tian J, Zhang B*. Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts. Brain Res Bull. 2020; 159:9-15.

Chen Y, Lin C, Guo Z, Zhao S, Zhu Y, Huang F, Shui G, Lam SM, Pu J, Yan Y, Liu Z, Zhang B*. Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer's Disease and Amnestic Mild Cognitive Impairment Patients. J Alzheimers Dis. 2020;73(2):811-818.

Yan YP, Xu CY, Gu LY, Zhang B, Shen T, Gao T, Tian J, Pu JL, Yin XZ, Zhang BR*, Zhao GH. Genetic testing of FUS, HTRA2, and TENM4 genes in Chinese patients with essential tremor. CNS Neurosci Ther. 2020 Mar 20. doi: 10.1111/cns.13305. Online ahead of print.

Ruan Y, Zheng R, Lin ZH, Gao T, Xue NJ, Cao J, Tian J, Zhang BR*, Pu JL. Genetic analysis of arylsulfatase A (ARSA) in Chinese patients with Parkinson's disease. Neurosci Lett. 2020 May 26:135094.

You Chen, Zhidong Cen, Xiaosheng Zheng, Qinqing Pan, Xinhui Chen, Lili Zhu, Si Chen, Hongwei Wu, Fei Xie, Haotian Wang, Dehao Yang, Lebo Wang, Baorong Zhang and Wei Luo * .LRP10 in Autosomal-Dominant Parkinson’s Disease.Movement Disorders, 2019.

Cen Z, Chen Y, Chen S, Wang H, Yang D, Zhang H, Wu H, Wang L, Tang S, Ye J, Shen J, Wang H, Fu F, Chen X, Xie F, Liu P, Xu X, Cao J, Cai P, Pan Q, Li J, Yang W, Shan PF, Li Y, Liu JY, Zhang B, Luo W*. Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification. Brain. 2020 Feb 1;143(2):491-502. 

Wang B, Wang J, Cen Z, Wei W, Xie F, Chen Y, Sun H, Hu Y, Yang D, Lou Y, Chen X, Ouyang Z, Chen S, Wang H, Wang L, Wang S, Qiu X, Ding Y, Yin H, Wu S, Zhang B, Zang YF, Luo W*. Altered Cerebello-Motor Network in Familial Cortical Myoclonic Tremor With Epilepsy Type 1. Mov Disord. 2020 Mar 4. doi: 10.1002/mds.28014. Online ahead of print. 

Chen Y, Cen Z, Chen X, Wang H, Chen S, Yang D, Fu F, Wang L, Liu P, Wu H, Zheng X, Xie F, Ouyang Z, Zhang Y, Zhou Y, Huang X, Wang F, Huang G, An H, Liang Y, Hong W, Wang A, Huang S, Chen W, Yin L, Yang Y, Huang H, Zeng R, Zhao N, Jiang B, Zhang B, Luo W*. Chinese PFBC Study Group. MYORG Mutation Heterozygosity Is Associated With Brain Calcification. Mov Disord. 2020 Apr;35(4):679-686.

Foo JN, Chew EGY, Chung SJ, Peng R, Blauwendraat C, Nalls MA, Mok KY, Satake W, Toda T, Chao Y, Tan LCS, Tandiono M, Lian MM, Ng EY, Prakash KM, Au WL, Meah WY, Mok SQ, Annuar AA, Chan AYY, Chen L, Chen Y, Jeon BS, Jiang L, Lim JL, Lin JJ, Liu C, Mao C, Mok V, Pei Z, Shang HF, Shi CH, Song K, Tan AH, Wu YR, Xu YM, Xu R, Yan Y, Yang J, Zhang B, Koh WP, Lim SY, Khor CC, Liu J, Tan EK*. Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.  JAMA Neurol. 2020 Apr 20:e200428.

Hanqin Li, Zhixing Hu, Houbo Jiang, Jiali pu, Ilana Selli, Jingxin Qiu, Baorong Zhang, Jian Feng*. TET1 Defciency Impairs Morphogen-free Diferentiation of Human Embryonic Stem Cells to Neuroectoderm. Scientific RepoRtS .2020,10:10343.

Current Program

The mechanism for Parkin mutation leads to the degeneration of dopaminergic neurons by combining the technologies of iPSCs and new gene editing tools. Funding Source: National Natural Science Foundation of China.

The construction of the system of diagnosis and treatment of early Parkinson's Disease based on multi-modal imaging and nasal kinetic oscillation stimulate. Funding Source: The Key Research and Development Program of Zhejiang Province.

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