Zhang Gensheng, M.D., Ph.D.

Position:Vice Chair of Intensive Care Unit

Department:Intensive Care Unit

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Clinical / Research Interests

Severe infection like pneumonia, bloodstream infection; sepsis/organ protection; acute respiratory distress syndrome (ARDS).

Professional Highlights

Medical Talents Training Target of Zhejiang Province, Health Commision of Zhejiang Province, 2017 

"151 Talents" of Zhejiang Province, 2015

Young Investigator Award, Chinese Society of Critical Care Medicine, 2015 

Professional Appointments

Editor, Chinese Journal of Emergency Medicine

Reviewer, Cell Death & Disease, 2013-present

Reviewer, Oxid Med Cell Longev, 2013-present

Reviewer, Gene Therapy, 2013-present

Reviewer, BMC Pulmonary Medicine, 2013-present

Reviewer, European Journal of Clinical Microbiology & Infectious Diseases, 2013-present

Reviewer, Journal of Intensive Care Medicine, 2013-present

Reviewer, Respiratory Care, 2013-present

Reviewer, World Journal of Emergency Medicine, 2013-present

Reviewer, Chinese Medical Journal, 2013-present

Education Experience

Research Summary

Dr. Zhang's current research focuses on severe infection or sepsis/septic shock. He has published more than 30 SCI papers. Dr. Zhang attempts to investigate the immune and molecular mechanisms of severe infection or sepsis/septic shock, and try to find new non-antibiotic strategy to prevention or treatment of severe infection.


Zhang K, Zhang G* (Corresponding author). An updated meta-analysis of Modified Early Warning Scores in patients with sepsis outside Intensive Care Unit. J Infect. 2020 Jul;81(1): e100-e101. doi:10.1016/j.jinf.2020.04.015. (SCI, 2019, IF= 4.842) 

Zheng C#, Zhang S#, Chen Q#, Zhong L, Huang T, Zhang X, Zhang K, Zhou H, Cai J, Du L, Wang C, Cui W, Zhang G*(Corresponding author). Clinical Characteristics and Risk Factors of Polymicrobial Staphylococcus Aureus Bloodstream Infections. Antimicrob Resist Infect Control. 2020 May 27;9(1):76. doi: 10.1186/s13756-020-00741-6. (SCI, 2019, IF= 3.594)

Zhang G#, Zhang K#, Zheng X, Cui W, Hong Y, Zhang Z*. Performance of the MEDS score in predicting mortality among emergency department patients with a suspected infection: a meta-analysis. Emerg Med J. 2020 Apr;37(4):232-239. doi: 10.1136/emermed-2019-208901. (SCI, 2019, IF= 2.491)

Zheng C#, Cai J#, Liu H#, Zhang S, Zhong L, Xuan N, Zhou H, Zhang K, Wang Y, Zhang X, Tian B, Zhang Z, Wang C, Cui W, Zhang G* (Corresponding author). Clinical Characteristics And Risk Factors In Mixed-Enterococcal Bloodstream Infections. Infect Drug Resist. 2019 Oct 31;12:3397-3407. doi: 10.2147/IDR.S217905. (SCI, 2019, IF=2.984) 

Zhang S, Zhang K, Yu Y, Tian B, Cui W, Zhang G* (Corresponding author). A new prediction model for assessing the clinical outcomes of ICU patients with community-acquired pneumonia: a decision tree analysis. Ann Med. 2019 Feb;51(1):41-50. doi: 10.1080/07853890.2018.1518580. (SCI, 2019, IF= 3.243)  

Dong Z, Zhang L, Xu W, Zhang G* (Corresponding author). EGFR may participate in immune evasion through regulation of B7H5 expression in nonsmall cell lung carcinoma. Mol Med Rep. 2018 Oct;18(4):3769-3779. doi: 10.3892/mmr.2018.9361. (SCI, 2019, IF= 2.1)

Zhang G#, Zhang K#, Cui W, Hong Y, Zhang Z*. The effect of enteral versus parenteral nutrition for critically ill patients: A systematic review and meta-analysis. J Clin Anesth. 2018 Dec; 51:62-92. doi: 10.1016/j.jclinane.2018.08.008. (SCI, 2019, IF= 6.039)

Wang X#, Zhang S#, Li L, Hua J, Zhu L, Li L, Zhang G* (Corresponding author). Ticagrelor-induced thrombotic thrombocytopenic purpura: A case report and review of the literature. Medicine (Baltimore). 2018 Jun;97(26):e11206. doi: 10.1097/MD.0000000000011206. (SCI, 2019, IF= 1.552)

Huang X#, Xiu H#, Zhang S, Zhang G* (Corresponding author). The Role of Macrophages in the Pathogenesis of ALI/ARDS. Mediators Inflamm. 2018 May 13;2018:1264913. doi: 10.1155/2018/1264913. (SCI, 2018, IF=3.758)

Zhang G#, Lin X#, Cai J#, Zhang R, Xiu H, Tian B, Cui W*. Characteristics of clinical and environmental vanM-carrying vancomycin-resistant enterococci isolates from an infected patient. Int J Antimicrob Agents. 2018 Jun;51(6):932-935. doi: 10.1016/j.ijantimicag.2018.01.003.  (SCI, 2019, IF=4.621) 

Pan S#, Huang X#, Wang Y#, Li L, Zhao C, Yao Z, Cui W, Zhang G* (Corresponding author). Efficacy of intravenous plus intrathecal/intracerebral ventricle injection of polymyxin B for post-neurosurgical intracranial infections due to MDR/XDR Acinectobacter baumannii: a retrospective cohort study. Antimicrob Resist Infect Control. 2018 Jan 19;7:8. doi: 10.1186/s13756-018-0305-5. (SCI, 2019, IF= 3.594)

Zhang G# (Corresponding author), Chen M# , Zhang S , Zhou H, Ji X, Cai J, Lou T, Cui W, Zhang N. Efficacy of caspofungin combined with trimethoprim/sulfamethoxazole as first-line therapy to treat non-HIV patients with severe pneumocystis pneumonia. Exp Ther Med. 2018 Feb;15(2):1594-1601. doi: 10.3892/etm.2017.5516.  (SCI, 2019, IF=1.785)

Gensheng Zhang#, Kai Zhang#, Wei Cui, Yucai Hong, Zhongheng Zhang*. The effect of early mobilization for critical ill patients requiring mechanical ventilation: a systematic review and meta-analysis. Journal of Emergency and Critical Care Medicine; 2018, 2:9. doi: 10.21037/jeccm.2018.01.04. 

Wang YS#, Li YY#, Cui W, Li LB, Zhang ZC, Tian BP, Zhang GS* (Corresponding author). Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain. Inflammation. 2017 Dec;40(6):2052-2061. doi: 10.1007/s10753-017-0645-y. (SCI, 2019, IF= 3.212)

Song HZ#, Gu JX#, Xiu HQ, Cui W, Zhang GS* (Corresponding author). The value of high-flow nasal cannula oxygen therapy after extubation in patients with acute respiratory failure. Clinics (Sao Paulo). 2017 Oct;72(9):562-567. doi: 10.6061/clinics/2017(09)07. (SCI, 2019, IF= 1.435) 

Zhang G#, Lin X#, Zhang S#, Xiu H, Pan C, Cui W*. A Protective Role of Glibenclamide in Inflammation-Associated Injury. Mediators Inflamm. 2017; 2017:3578702.  (SCI, 2019, IF= 3.758)

Lin X#, Xu Z, Wang P, Xu Y, Zhang G* (Corresponding author). Role of PiCCO monitoring for the integrated management of neurogenic pulmonary edema following traumatic brain injury: A case report and literature review.  Exp Ther Med. 2016 Oct; 12 (4): 2341-2347.  (SCI, 2019, IF= 1.785)

Zhang S#, Pan C#, Zhou F, Yuan Z, Wang H, Cui W, Zhang G* (Corresponding author). Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis. Oxid Med Cell Longev. 2015;2015:593407. Epub 2015 May 11. (SCI, 2019, IF= 5.076)

Cui W#, Zhang S#, Cai Z, Hu X, Zhang R, Wang Y, Li N, Chen Z, Zhang G* (Corresponding author). The Antidiabetic Agent Glibenclamide Protects Airway Hyperresponsiveness and Inflammation in Mice. Inflammation. 2015 Apr;38(2):835-45. (SCI, 2019, IF= 3.212)

Zhang S#, Wang Y#, Xu Z, Ding L, Wang L, Li L, Zhang G* (Corresponding author). High fever and multi-nodular lung consolidations after whole lung lavage in a patient with pulmonary alveolar proteinosis. Springerplus. 2015 Feb 5;4:61. (SCI, 2016, IF= 1.13)

Zhang G#, Yu Y#, Zhang S, Li N, Xu H, Cui W*. Empyema, acute respiratory failure, and septic shock after aspiration of a soft-shelled turtle (Pelodiscus sinensis) bone by an adult. Springerplus. 2014 Aug 20;3:452. (SCI, 2016, IF= 1.13) 

Li N#, Huang HQ, Zhang GS* (Corresponding author). Association between SOD2 C47T polymorphism and lung cancer susceptibility: a meta-analysis. Tumour Biol. 2014 Feb; 35(2):955-9.  (SCI, 2016, IF= 3.65)

Zhang G#, Wang P#, Yang G, Cao Q, Wang R*. The Inhibitory Role of Hydrogen Sulfide in Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma. Am J Pathol. 2013 Apr; 182 (4):1188-95. doi: 10.1016/j.ajpath.2012.12.008. Epub 2013 Feb 8. (SCI, 2019, IF= 3.491)

Zhang G#, Wang P#, Qiu Z, Qin X, Lin X, Li N, Huang H, Liu H, Hua W, Chen Z, Zhao H, Li W, Shen H*. Distant lymph nodes serve as pools of Th1 cells induced by neonatal BCG vaccination for the prevention of asthma in mice. Allergy. 2013 Mar;68(3):330-8. doi: 10.1111/all.12099. Epub 2013 Jan 25. (SCI, 2019, IF= 8.706) 

Qin XJ#, Zhang GS# (Co-first author), Zhang X, Qiu ZW, Wang PL, Li YW, Li W, Xie QM, Ke YH, Lee JJ, Shen HH*. Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice. Allergy. 2012 Dec;67(12):1547-56. doi: 10.1111/all.12048. Epub 2012 Oct 11. (SCI, 2019, IF= 8.706)

Zhang GS#, Wang PL, Huang HQ, Shen HH*. New insights into the effects of Mycobacterium bovis Bacillus Calmette-Guérin on asthma. Chin Med J (Engl). 2009 Mar 5;122(5):577-83. (SCI, 2019, IF= 1.585) 

Zhang GS#, Xu ZH, Cui W, Zhou F, Xia Y, Li W, Li LB, Shen HH*. A case with lethal endobronchial lymphoma presenting with respiratory failure requiring intubation and mechanical ventilation. Chin Med J (Engl). 2008 Feb 5;121(3):280-2. (SCI, 2019, IF= 1.585)

Current Program

Study of the role of CSN5-mediated de-neddylation on macrophage against vancomycin-resistant enterococci (VRE) infection and related mechanisms. Funding Source: National Natural Science Foundation of China.

The role and associated mechanisms of neddylation in macrophage against methicillin-resistant Staphylococcus aureus(MRSA) infection. Funding Source: Natural Science Foundation of Zhejiang.

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