Chen Gao, M.D.

Position:Chair of Neurosurgery

Department:Neurosurgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician, Professor


Appointment

Clinical / Research Interests

Cerebrovascular disease

Central nervous system tumors 

Traumatic brain injury, especially in intracranial aneurysm and intracranial hemorrhage


Professional Highlights

Chinese Medical Scientific and Technological Award, Second Prize, 2016

Zhejiang University School of Medicine Outstanding Scientific Research Achievement Award, 2014 and 2015

Zhejiang Scientific and Technological Progress Award, First Prize, 2014

Professional Appointments

Member, Specialized Committee, Chinese Society of Neurosurgery

Member, Specialized Committee, Chinese Society of Neurosurgeons

Vice Chair, Specialized Committee of Neurosurgery, Chinese Association of Integrative Medicine

Vice Chair, Zhejiang Society of Neurosurgery

Chair, Specialized Committee of Neurosurgery, Zhejiang Association of Integrative Medicine

Member, World Federation of Neurosurgical Society

Education Experience

Research Summary

Publications

J Zhuang, Y Peng, C Gu, H Chen, G Chen. Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage. Transl Stroke Res. 2020 Sep 12. 

Yucong Peng, Jianfeng Zhuang, Guangyu Ying, Hanhai Zeng, Hang Zhou, Yang Cao, Huaijun Chen, Chaoran Xu, Xiongjie Fu, Hangzhe Xu, Jianru Li, Shenglong Cao, Jingyin Chen, Chi Gu, Feng Yan, Gao Chen. Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. J Neuroinflammation. 2020 May 25;17(1):165.

YH Lin, L Guo, F Yan, ZQ Dou, Q Yu, G Chen. Long non-coding RNA HOTAIRM1 promotes proliferation and inhibits apoptosis of glioma cells by regulating the miR-873-5p/ZEB2 axis. Chin Med J (Engl). 2020 Jan 20;133(2):174-182. 

RA Wu, JH A, ZA Hang, LA Yin, CX A, YL A, TC A, BX B, YA Feng, CA Gao. Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C. Neurochem Int. 2020 Mar;134:104656. 

Zhangqi Dou, Qian Yu, Guangyuan Wang, Shenglian Wu, Cesar Reis, Wu Ruan, Feng Yan, Gao Chen. Circular RNA expression profiles alter significantly after intracerebral hemorrhage in rats. Brain Res. 2020 Jan 1;1726:146490.

Shenglian Wu, Yiting Wei, Xiaobo Yu, Yucong Peng, Pingyou He, Hangzhe Xu, Cong Qian, Gao Chen. Retrospective analysis of brain abscess in 183 patients: A 10-year survey. Medicine (Baltimore). 2019 Nov; 98(46):e17670. 

Jingsen Chen, Hanghuang Jin, Hangzhe Xu, Yucong Peng, Liyong Jie, Demin Xu, Lili Chen, Tao Li, Linfeng Fan, Pinhyou He, Guangyu Ying, Chi Gu, Chun Wang, Lin Wang, Gao Chen. The Neuroprotective Effects of Necrostatin-1 on Subarachnoid Hemorrhage in Rats Are Possibly Mediated by Preventing Blood-Brain Barrier Disruption and RIP3-Mediated Necroptosis. Cell Transplant. 2019 Nov; 28(11):1358-1372. 

Liang Xia, Dekang Nie, Guangtao Wang, Caixing Sun, Gao Chen. FER1L4/miR-372/E2F1 works as a ceRNA system to regulate the proliferation and cell cycle of glioma cells. J Cell Mol Med. 2019 May; 23(5):3224-3233. 

Liansheng Gao, Zhongyuan Zhang, Weilin Xu, Tao Li, Guangyu Ying, Bing Qin, Jianru Li, Jingwei Zheng, Tengfei Zhao, Feng Yan, Yongjian Zhu, Gao Chen. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Front Mol Neurosci. 2019 Feb 22; 12:42.

B Qin, L Wang, L Gao, J Shi, Y Peng, G Chen. Recovered bone flap tilting after encephalo-myo-synangiosis: A complication. Clin Neurol Neurosurg. 2019 Mar; 178:13-19. 

Tao Li, Weilin Xu, Liansheng Gao, Guoping Guan, Zhongyuan Zhang, Pingyou He, Hangzhe Xu, Linfeng Fan, Feng Yan, Gao Chen. Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB J. 2019 Feb; 33(2):1727-1741.

Fu-Yi Liu, Jing Cai, Chun Wang, Wu Ruan Guo-Ping Guan, Hai-Zhou Pan, Jian-Ru Li, Cong Qian, Jing-Sen Chen, Lin Wang, Gao Chen. Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. J Neuroinflammation. 2018 Dec 20;15(1):347.

Tao Li, Weilin Xu, Liansheng Gao, Guoping Guan, Zhongyuan Zhang, Pingyou He, Hangzhe Xu, Linfeng Fan, Feng Yan, Gao Chen. Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB J. 2019 Feb; 33(2):1727-1741.

Bing Qin, Liansheng Gao, Junwen Hu, Lin Wang, Gao Chen. Intracerebral hematoma after endoscopic fenestration of an arachnoid cyst: A case report. Medicine (Baltimore). 2018 Nov; 97(44):e13106. 

Haiyan Zheng, Weilin Xu, Yili Chen, Shiying Gai, Gao Chen. A rare case of deep cerebral venous thrombosis secondary to traumatic epidural hematoma: Case report. Medicine (Baltimore). 2018 Sep;97(36):e11587.

Yucong Peng, Pingyou He, Linfeng Fan, Hangzhe Xu, Jianru Li, Ting Chen, Wu Ruan, Zhangqi Dou and Gao Chen. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats. Am J Chin Med. 2018; 46(6):1225-1241. 

Ding-Bo Yang, Xiao-Qiao Dong, Quan Du, Wen-Hua Yu, Yong-Ke Zheng, Wei Hu, Ke-Yi Wang, Fang-Hui Chen, Yuan-Sheng Xu, Yi Wang, Gao Chen. Clinical relevance of cleaved RAGE plasma levels as a biomarker of disease severity and functional outcome in aneurysmal subarachnoid hemorrhage. Clin Chim Acta. 2018 Nov; 486:335-340. 

Ting Chen, Haizhou Pan, Jianru Li, Hangzhe Xu, Hanghuang Jin, Cong Qian, Feng Yan, Jingyin Chen, Chun Wang, Jingsen Chen, Lin Wang, Gao Chen. Inhibiting of RIPK3 attenuates early brain injury following subarachnoid hemorrhage: Possibly through alleviating necroptosis. Biomed Pharmacother. 2018 Nov; 107:563-570. 

Yajuan Tang, Huimin Chen, Feiqiang Ma, Rudi Scharnweber, Jianmin Zhang, Gao Chen, Qun Wu. Experience Using the Pterional Keyhole Approach for the Treatment of Ruptured Intracranial Aneurysms of the Anterior Circulation. World Neurosurg. 2018 Oct; 118:e800-e805. 

Liansheng Gao, Weilin Xu, Tao Li, Jingwei Zheng, Gao Chen. Accuracy of 11C-choline positron emission tomography in differentiating glioma recurrence from radiation necrosis: A systematic review and meta-analysis. Medicine (Baltimore). 2018 Jul; 97(29):e11556.

Bing Fang, Cong Qian, Jun Yu, Liang Xu, Dingyao Jiang, Jing Xu, Jianmin Zhang, Gao Chen. Transarterial Embolization of Cavernous Sinus Dural Arteriovenous Fistulas With Ipsilateral Inferior Petrosal Sinus Occlusion via the Ascending Pharyngeal Artery. World Neurosurg. 2018 Sep; 117:e603-e611.

Liansheng Gao, Weilin Xu, Tao Li, Jingyin Chen, Anwen Shao, Feng Yan, Gao Chen. Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage. Cell Transplant. 2018 Dec; 27(12):1809-1824. 

Liansheng Gao, Weilin Xu, Shuangbo Fan, Tao Li, Tengfei Zhao, Guangyu Ying, Jingwei Zheng, Jianru Li, Zhongyuan Zhang, Feng Yan, Yongjian Zhu, Gao Chen. MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats. Biofactors. 2018 May 24. 

Liansheng Gao, Weilin Xu, Tao Li, Xiaobo Yu, Shenglong Cao, Hangzhe Xu, Feng Yan, Gao Chen. Accuracy of magnetic resonance venography in diagnosing cerebral venous sinus thrombosis. Thromb Res. 2018 Jul; 167:64-73.

Qun Li, Yucong Peng, Linfeng Fan, Hangzhe Xu, Pingyou He, Shenglong Cao, Jianru Li, Ting Chen, Wu Ruan, Gao Chen. Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway. Biomed Pharmacother. 2018 Mar; 99:947-955.

Peng Yucong, Jin Jianxiang, Fan Linfeng, Xu Hangzhe, He Pingyou, Li Jianru, Chen Ting,  Ruan Wu,  Chen Gao. Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway. Neurochem Res. 2018 Apr; 43(4):785-795.

L Xia, C Fang, G Chen, C Sun. Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis. BMC Cancer. 2018 Jan 6; 18(1):48.

Liansheng Gao, Weilin Xu, Tao Li, Huali Luo, Shiying Gai, Ruxin Xing, Gao Chen, Yili Chen. A Rare Case of Angiosarcoma With Skull Masses and Erythropenia and Thrombocytopenia: A Case Report and Review of Literature. Medicine (Baltimore). 2017 Dec; 96(49):e8787.

Cong Qian, Jianxiang Jin, Jingyin Chen, Jianru Li, Xiaobo Yu, Hangbo Mo, Gao Chen. SIRT1 Activation by Resveratrol Reduces Brain Edema and Neuronal Apoptosis in an Experimental Rat Subarachnoid Hemorrhage Model. Mol Med Rep. 2017 Dec; 16(6):9627-9635.

Jian-Ru, Li; Hang-Zhe, Xu; Sheng, Nie; Yu-Cong, Peng; Lin-Feng, Fan; Zhi-Jiang, Wang; Cheng, Wu; Feng,Yan; Jing-Yin, Chen; Chi, Gu; Chun, Wang; Jing-Sen, Chen; Lin, Wang; Gao, Chen. Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats. Journal of Neuroinflammation. 2017 Sep 13; 14(1):186.

Lin-feng Fan, Ping-you He, Yu-cong Peng, Qing-hua Du, Yi-jun Ma, Jian-xiang Jin, Hang-zhe Xu, Jian-ru Li, Zhi-jiang Wang, Sheng-long Cao, Tao Li, Feng Yan, Chi Gu, Lin Wang, Gao Chen. Mdivi-1 Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via the Suppression of Inflammation-Related Blood-Brain Barrier Disruption and Endoplasmic Reticulum Stress-Based Apoptosis. Free Radic Biol Med. 2017 Nov; 112:336-349.

F Yan, X Tan, W Wan, Dixon, Brandon J, R Fan, B Enkhjargal, Q Li, J Zhang, G Chen, Zhang, John H. ErbB4 Protects Against Neuronal Apoptosis via Activation of YAP/PIK3CB Signaling Pathway in a Rat Model of Subarachnoid Hemorrhage. Exp Neurol. 2017 Nov; 297:92-100.

Shenglong Cao, Sudeep Shrestha, Jianru Li, Xiaobo Yu, Jingyin Chen, Feng Yan, Guangyu Ying, Chi Gu, Lin Wang, Gao Chen. Melatonin-mediated Mitophagy Protects Against Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NLRP3 Inflammasome Activation. Sci Rep. 2017 May 25; 7(1):2417.

Hangzhe Xu, Jianru Li, Zhijiang Wang, Majing Feng, Yongfeng Shen, Shenglong Cao, TaoLi, Yucong Peng, Linfeng Fan, Jingyin Chen, Chi Gu, Feng Yan, Lin Wang, Gao Chen. Methylene blue attenuates neuroinflammation after subarachnoid hemorrhage in rats through the Akt/GSK-3β/MEF2D. Brain, Behavior, and Immunity. 2017 Oct; 65 125-139.

Hangzhe Xu, Zhijiang Wang, Jianru Li, Haijian Wu, Yucong Peng, Linfeng Fan, Jingyin Chen, Chi Gu, Feng Yan, Lin Wang, Gao Chen. The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plast. 2017; 2017:5405104. 

Shenglong Cao, Ping Zhu, Xiaobo Yu, Jingyin Chen, Jianru Li, Feng Yan, Lin Wang, Jun Yu, Gao ChenPharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt. Mol Neurobiol. 2017 Apr; 54(3):1808-1817.

Han-Hai Zeng, Xiao-Bo Yu, Lin-Feng Fan, Gao Chen. Diagnostic Clues and Treatment of Intradural Cranial Chordoma. Chin Med J (Engl). 2016 Dec 5; 129(23):2895-2896.

Lin Wang, Cong Qian, Xiaobo Yu, Xiongjie Fu, Ting Chen, Chi Gu, Jingyin Chen, Gao Chen. Indirect Bypass Surgery May Be More Beneficial for Symptomatic Patients With Moyamoya Disease at Early Suzuki Stage. World Neurosurg. 2016 Nov; 95:304-308.

Chun Wang, Xiaobo Yu, Sudeep Shrestha, Cong Qian, Lin Wang, Gao Chen. Predicted Model for Postoperative Seizure Outcomes After the Surgical Resection of Supratentorial Cavernous Malformations. Medicine (Baltimore). 2016 Jun; 95(26): e4078.

Guang-Yu Ying, Chao-Hui Jing, Jian-Ru Li, Cheng Wu, Feng Yan, Jing-Yin Chen, Lin Wang, Brandon J Dixon, Gao Chen. Apoptosis-Related Early Brain Injury in Rats Subjected to Subarachnoid Hemorrhage Are Modulated by Heat Shock Protein 70/Matrix Metalloproteinases and Heat Shock Protein 70/AKT Pathways. Neurosurgery. 2016 Aug; 79(2):286-95.

Ting Chen, Wei Wang, Jian-Ru Li, Hang-Zhe Xua, Yu-Cong Peng, Lin-Feng Fan, Feng Yan, Chi Gu, Lin Wang, Gao Chen. PARP Inhibition Attenuates Early Brain Injury Through NF-κB/MMP-9 Pathway in a Rat Model of Subarachnoid Hemorrhage. Brain Res. 2016 Aug 1;1644:32-8.

Shenglong Cao, Ping Zhu, Xiaobo Yu, Jingyin Chen, Jianru Li, Feng Yan, Lin Wang, Jun Yu, Gao Chen. Hydrogen Sulfide Attenuates Brain Edema in Early Brain Injury After Subarachnoid Hemorrhage in Rats: Possible Involvement of MMP-9 Induced Blood-Brain Barrier Disruption and AQP4 Expression. Neurosci Lett. 2016 May 16; 621:88-97. 

Shenglong Cao, Ping Zhu, Xiaobo Yu, Jingyin Chen, Jianru Li, Feng Yan, Lin Wang, Jun Yu, Gao Chen. Epidermoid Cyst Located in Facies Convexa Cerebri With Atypical Images, Chin Med J (Engl). 2016 Feb 5;129(3):374-5.

Cong Qian, Xiaobo Yu, Jianru Li, Jingyin Chen, Lin Wang, Gao Chen. The Efficacy of Surgical Treatment for the Secondary Prevention of Stroke in Symptomatic Moyamoya Disease: A Meta-Analysis. Medicine (Baltimore). 2015 Dec;94(49):e2218.

Jingyin Chen, Cong Qian, Hongyu Duan, Shenglong Cao, Xiaobo Yu, Jianru Li, Chi Gu, Feng Yan, Lin Wang, Gao Chen. Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats. J Pineal Res. 2015 Nov; 59(4) 469-477.

Di Ruan; Xiao-Bo Yu; Sudeep Shrestha; Lin Wang; Gao Chen. The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 25; 10(8):e0136619.

Chi Gu, Yifei Wang, Jianru Li, Jingyin Chen, Feng Yan, Cheng Wu, Gao Chen. Rosiglitazone Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats. Brain Res. 2015 Oct 22; 1624:199-207. 

Jianru Li, Jingsen Chen, Hangbo Mo, Jingyin Chen, Cong Qian, Feng Yan, Chi Gu, Qiang Hu, Lin Wang, Gao Chen. Mol Neurobiol. 2016 May; 53(4):2668-78. 

Current Program

The role and mechanism of CBLB mediated microglia efferocytosis in regulating neuronal pyroptosis after subarachnoid hemorrhage. Funding Source: General Program of National Natural Science Foundation of China.

The role and mechanism of mitophagy mediated necroptosis in early brain injury after subarachnoid hemorrhage. Funding Source: General Program of National Natural Science Foundation of China.

Clinical study of min-invasive treatment for Hypertensiveintracranial hemorrhage. Funding Source: Key Research and Development Project of Zhejiang Province.

Building and Evaluation of a Normalized System in Mininally Invasive Treatment of Intracerebral Hemorrhage based on Radiomics.  Funding Source: National Key Research and Development Program of China.

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