Mao Zhengwei, Ph.D.

Department:HPB Surgery, The Second Affiliated Hospital Zhejiang Unviersity School of Medicine

Department of Polymer Science and Engineering, Zhejiang University

School:Zhejiang University, China

Academic Rank:Professor


Clinical / Research Interests

Professional Highlights

First prize (3/8), Zhejiang Provincial Science and Technology Award, 2020

Excellent young investigator award, Chinese Society for Biomaterials, Polymer Division”, 2019

Excellent young investigator award,“Natural Science Foundation of China”, 2018

First prize (2/4), Zhejiang Provincial Science and Technology Award, 2018

Young investigator award,“Chinese Association for Biomaterials”, 2017

Outstanding young investigator award, Natural Science foundation of Zhejiang Province, China, 2016


Professional Appointments

Education Experience

2007.8 – 2009.12, Postdoc fellow, Max Planck Institute Colloids and Interfaces, Germany

Supervisors: Prof. Moehwald and Dr. Dayang Wang

2002.9 – 2007.6, Ph.D in Materials Science, Zhejiang University, China

Supervisors: Prof. Jiacong Shen and Prof. Changyou Gao

Research Summary

Publications

Totally published over 150 papers on peer-review journals such as Nat Nano, Nat Comm, Sci Adv, Adv Mater, J Am Chem Soc, Angew Chem Int Ed, Biomaterials, ACS Nano, Nano Letters and so on. The publications were cited for over 9,500 times and H index is 52.

Selected publications (*corresponding authors)

Fangfang Cao, Lulu Jin, Yong Gao, Yuan Ding, Hongyang Wen, Zhefeng Qian, Chenyin Zhang, Liangjie Hong, Huang Yang, Jiaojiao Zhang, Zongrui Tong, Weilin Wang*, Xiaoyuan Chen*, Zhengwei Mao*. Artificial Enzymes-Armed Bifidobacterium Longum Probiotics for Alleviating Intestinal Inflammation and Microbiota Dysbiosis. Nature Nanotechnology 2023, https://doi.org/10.1038/s41565-023-01346-x.

Lulu Jin, Fangfang Cao, Yong Gao, Chenying Zhang, Zhefeng Qian, Jiaojiao Zhang, Zhengwei Mao*. Microenvironment Activated Nanozymes-Armed Bacteriophages Efficiently Combat Bacterial Infection. Advanced Materials, 2023, DOI: 10.1002/adma.202301349.

Jiaojiao Zhang; Bingqiang Gao; Binglin Ye; Zhongquan Sun; Zhefeng Qian; Lisha Yu; Yanli Bi; Lie Ma; Yuan Ding*; Yang Du*; Weilin Wang*; Zhengwei Mao*. Mitochondrial-targeted Delivery of Polyphenol-Mediated Antioxidases Complexes against Pyroptosis and Inflammatory Diseases. Advanced Materials 2023, 35, 2208571.

Yuan Ding, Zongrui Tong, Lulu Jin, Binglin Ye, Jiong Zhou*, Zhongquan Sun, Huang Yang, Liangjie Hong, Feihe Huang, Weilin Wang*, and Zhengwei Mao*. A NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging-Guided Cancer Radiochemotherapy. Advanced Materials 2022, Feb; 34(7): 2106388.

Ding Y, Sun ZQ, Gao Y, Zhang ST, Yang CX, Qian ZF, Jin LL, Zhang JJ, Zeng C, Mao ZW*, Wang WL*. Plasmon-Driven Catalytic Chemotherapy Augments Cancer Immunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway. Advanced Materials 2021, DOI: 10.1002/adma.202102188.

Ren ZG, Sun SC, Sun RR, Cui GY, Hong LJ, Rao BC, Li A, Yu ZJ*, Kan QC*, Mao ZW*. A Metal-Polyphenol Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy. Advanced Materials, 2020, 32: 1906024.

Chen YW, Shen WL, Tang CQ, Huang JY, Fan CM, Yin Z, Hu YJ, Chen WS, Ouyang HW, Zhou YT*, Mao ZW*, Chen X*. Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification. Science Advances 2020, 6: eaay9526.

Xinlian Zhao, Lulu Jin, Zhixin Zhu, Haohao Lu, Haifei Shi*, Qi Zhong, Joaquim Miguel Oliveira, Rui L. Reis, Changyou Gao*, Zhengwei Mao*. Conotoxin loaded dextran microgel particles alleviate effects of spinal cord injury by inhibiting neuronal excitotoxicity. Applied Materials Today 2021, 23, 101064.

Yuan Ding, Yanjie Li, Zhongquan Sun, Xin Han, Yining Chen, Yao Ge, Zhengwei Mao* and Weilin Wang*. Cell-derived extracellular vesicles and membranes for tissue repair. Journal of Nanobiotechnology 2021,19, 368.

Zheng QQ, Shen HT, Tong ZR, Cheng LX, Xu YZ, Feng ZY, Liao SY, Hu XJ, Pan ZY*, Mao ZW*, Wang Y*. A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway. Theranostics 2021, 11, 147-163.

Tong ZR, Jin LL, Oliveira JM, Reis RL, Zhong Q, Mao ZW*, Gao CY*. Adaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells. Bioactive Materials 2021, 6, 1375-1387.

Liu TF, Xiao BW, Xiang F, Tan JL, Chen Z, Zhang XR, Wu CZ, Mao ZW*, Luo GX*, Chen XY*, Deng J*. Ultrasmall Copper-Based Nanoparticles for Superior Reactive Oxygen Species Scavenging and Alleviation of Inflammation Related Diseases. Nature Communications 2020, 11: 2788.

Ding Y, Xu Hao, Xu C, Tong ZR, Zhang ST, Bai Y, Chen YN, Xu QH, Zhou LZ, Ding H, Sun ZQ, Yan S*, Mao ZW*, Wang WL*. A Nanomedicine Fabricated from Gold Nanoparticles Decorated Metal Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy. Advanced Science 2020, 7: 2001060.

Ding Y, Sun ZQ, Tong ZR, Zhang ST, Min J, Xu QH, Zhou LZ, Mao ZW*, Wang WL*. Tumor microenvironment-responsive multifunctional peptide coated ultrasmall gold nanoparticles and their application in cancer radiotherapy. Theranostics 2020, 10(12), 5195-5208.

Yang Y, Ding Y, Fan B, Wang Y, Mao ZW*, Wang WL*, Wu JD*. Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis. Journal of Controlled Release 2020, 321, 463-474.

Yao YJ, Ding J, Wang ZY, Zhang HL, Xie JQ, Wang YC, Hong LJ, Mao ZW*, Gao JQ, Gao CY*. ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted yocardium in vivo. Biomaterials 2020, 232, 119726.

Zhu HTZ, Wang HH, Shi BB, Shangguan LQ, Tong WJ, Yu GC*, Mao ZW*, Huang FH*. Supramolecular peptide constructed by molecularLego allowing programmable self-assembly for photodynamic therapy. Nature Communications 2019, 10, 2412.

Yu GC, Yu S, Saha M, Zhou J, Cook TR, Yung BC, Chen J, Mao ZW*, Zhang FW, Zou ZJ, Liu YJ, Shao L, Wang S, Gao CY, Huang FH*, Stang PJ*, Chen XY*. A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy. Nature Communications 2018, 9, 4335.

Yu G, Yang Z, Fu X, Yung B, Yang J, Mao ZW*, Shao L, Hua B, Liu Y, Zhang F, Fan Q*, Jacobson O, Jin A, Gao C, Huang F*, Chen X*. Polyrotaxane-based supramolecular theranostics. Nature Communications 2018, 9 (1), 766.

Yu GC, Zhao XL, Zhou J, Mao ZW*, Huang XL, Wang, ZT, Hua, B, Liu, YJ, Zhang, FW, He, ZM, Jacobson, O, Gao CY, Wang, WL, Yu, CY, Zhu, XY, Huang FH*, Chen, XY*. Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity. J. Am. Chem. Soc. 2018, 140 (25), 8005-8019.

Yu G, Yung B, Zhou Z, Mao ZW*, Chen X*. Artificial Molecular Machines in Nanotheranostics. ACS Nano 2018, 12, 7-12.

Yu GC, Yang J, Fu X, Wang ZT, Shao L, Mao ZW*, Liu YJ, Yang Z, Zhang FW, Fan W, Song JB, Zhou ZJ, Gao CY, Huang FH*, Chen XY*, A Supramolecular Hybrid Material Constructed from Graphene Oxide and Pillar[6]arene-Based Host-Guest Complex as a Ultrasound and Photoacoustic Signals Nanoamplifier. Mater Horiz 2018, 5 (3), 429-435.

Bi CX, Chen J, Chen Y, Song Y, Li AR, Li SZ, Mao, ZW*, Gao CY, Wang DY, M?hwald, H, Xia HB*, Realizing a Record Photothermal Conversion Efficiency of Spiky Gold Nanoparticles in the Second Near-Infrared Window by Structure-Based Rational Design. Chem. Mater. 2018, 30 (8), 2709-2718.

Yu G, Zhang M, Saha M, Mao ZW*, Chen J, Yao Y, Zhou Z, Liu Y, Gao C, Huang F*, Chen X*, Stang P*. Antitumor Activity of a Unique Polymer That Incorporates a Fluorescent Self-Assembled Metallacycle. J. Am. Chem. Soc. 2017, 139, 15940?15949.

Peng LH, Huang Y, Zhang C, Niu J, Chen Y, Chu Y, Jiang Z, Gao J*, Mao ZW*. Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity. Biomaterials 2016, 103: 137-149.

W. Zhang, P. Jiang, Y. Chen, P. Luo, G. Li, B. Zheng, W. Chen, Z. Mao*, C. Gao*. Suppressing the cytotoxicity of CuO nanoparticles by uptake of curcumin/BSA particles. Nanoscale, 2016, 8: 9572-9582.

Yu S, Gao Y, Mei X, Ren TC, Liang S, Mao ZW*, Gao CY*. Preparation of an Arg-Glu-Asp-Val Peptide Density Gradient on Hyaluronic Acid-Coated Poly(ε-caprolactone) Film and Its Influence on the Selective Adhesion and Directional Migration of Endothelial Cells. ACS Applied Materials & Interfaces, 2016, 8(43): 29280-29288.

Ren TC, Yu S, Mao ZW*, Gao CY.* A complementary density gradient of zwitterionic polymer brushes and NCAM peptides for selectively controlling directional migration of Schwann cells. Biomaterials 2015, 56, 58-67.

Peng L, Niu J, Zhang Y, Han LJ, Zhang CZ, Wu JH, Wang XR, Gao JQ*, Mao ZW.* et al. Cell membrane capsules for encapsulation of chemotherapeutic and cancer cell targeting in vivo. ACS Applied Materials&Interfaces 2015, 7, 18628-18637.

Peng LH, Niu J, Zhang CZ, Yu W, Wu JH, Shan YH, Wang XR, Shen YQ, Mao ZW*, Liang WQ, Gao JQ.* TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells. Biomaterials, 2014, 35: 5605-5618.

Zhou XY, Dorn M, Vogt J, Spemann D, Yu W, Mao ZW*, Estrela-Lopis I, Donath E, Gao CY. A quantitative study of the intracellular concentration of graphene/noble metal nanoparticle composites and their cytotoxicity.” Nanoscale, 2014, 6, 8535-8542.

Han LL, Mao ZW*, Wu JD, Guo Y, Ren TC, Gao CY*. Directional cell migration through cell–cell interaction on polyelectrolyte multilayers with swelling gradients.” Biomaterials, 2013, 34(4): 975-984.


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