Department：Breast Surgery Department
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Physician
Key immune regulatory mechanisms of colorectal cancer microenvironmen: Zhejiang Provincial Natural Science Award/First Prize
Zhijiang Young Scholar (Immunology Society of Zhejiang province) 2021
Youth Scholar ward, Annual Meeting of the KSMO (2023), 11th International FACO Conference
Young Expert, Breast Cancer Professional Committee, Chinese Anti-Cancer Association
Committee Member, Youth Working group, Chinese Society of Immunology
Committee Member, Breast Cancer Committee, Zhejiang Anti-Cancer Association
Member, Standing Committee of Clinical Immunology Branch, Zhejiang Immunology Society
Deputy Chairman, Youth Committee of Breast Cancer Clinical Trial Committee, Zhejiang Society for Mathematical Medicine
PhD of Oncology, Zhejiang University School of Medicine, China, 2011/9 to 2014/7 Thesis Tile: Study on identification of resting colorectal cancer stem cells and IFN-γ targeted elimination, Supervisor: Prof. Huang Jian
Master of Clinical Medicine, Zhejiang University School of Medicine, China, 2009/9 to 2011/7 Supervisor: Prof. Wang Shenqing
Bachelor of Clinical Medicine, Zhejiang University School of Medicine, China, 2004/9 to 2009/7
Prof. Ni's primary research interests focus on the immune microenvironment and drug resistance mechanism of breast cancer, especially the pre-metastatic microenvironment of lymph node and viscera. Prof. Ni published a series of papers as first /corresponding author on Immunity, Signal Transduction and Targeted Therapy, Clinical Cancer Research, etc. Meanwhile, as the principal investigator, Prof. Ni conducted a number of clinical trials on breast cancer endoscopic surgery(NCT05600153) and early breast cancer screening (NCT06016790).
Lesang Shen#, Huanhuan Huan#, Zichen We#, Wuzhen Che#, Jiaxin L, Yao Ya, Jun Zhou, Jian Liu, Shanshan Su, Wenjie Xia, Ting Zhan, Xiuyan Y, Jun Shen, Weilan Wang, Jingxin Jian, Jian Huan*, Ming Jian*, Chao Ni*. Integrated transcriptomics, proteomics and functional analysis to characterize the tissue-specific small extracellular vesicle network of breast cancer. Medcomm, 2023 Dec 3;4(6):e433.
Huanhuan Huang#, Yao Yao#, Lesang Shen#, Jingxin Jiang#, Ting Zhang, Jia Xiong, Jiaxin Li, Shanshan Sun ,Siwei Zheng, Fang Jia, Jun Zhou, Xiuyan Yu, Wuzhen Chen, Jun Shen, Wenjie Xia, Xuan Shao, Qingqing Wang*, Jian Huang*, Chao Ni*. CD24hiCD27+Bregs within metastatic lymph nodes promote multi-drug resistance in breast cancer. Clin Cancer Res. 2023 Oct 13. doi: 10.1158/1078-0432.CCR-23-1759
Lesang Shen#, Huanhuan Huang#, Jiaxin Li, Wuzhen Chen, Yao Yao, Jianming Hu, Jun Zhou, Fengbo Huang* and Chao Ni*. Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature. Front Immunol. 2023 Jul 4:14:1199465
Jiaxin Li#, Jun Zhou#, Huanhuan Huang, Jiahuan Jiang, Ting Zhang*, Chao Ni*. Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): A novel population in the tumour microenvironment and immunotherapy target. Clin. Transl. Med. 2023;13:e1199.
Chao Ni#; Qingqing Fang#; Wuzhen Chen#; Jin-xin Jiang; Zhou Jiang; Jun Ye; Ting Zhang; FanboMeng; Wenjie Xia; Miaochun Zhong; Jian Huang*; Breast cancer derived exosome transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells, Signal Transduction and Targeted Therapy, 2020, 5(41): 1-14
Huang, Huanhuan#; Zhou, Jun#; Chen, Hailong#; Li, Jiaxin; Zhang, Chao; Jiang, Xia*; Ni, Chao*. The immunomodulatory effects of endocrine therapy in breast cancer., J Exp Clin Cancer Res, 2021, 40(1): 0-19
Pin Wu#; Dang Wu#; Chao Ni#; Jun Ye#; Wuzhen Chen; Guoming Hu; Zhen Wang; Changrong Wang; Zhigang Zhang; Wenjie Xia; Zhigang Chen; Ke Wang; Tao Zhang; Jinghong Xu; Yuehua Han; Ting Zhang; Xianguo Wu; Jianwei Wang; Weihua Gong; Shu Zheng; Fuming Qiu; Jun Yan*; Jian Huang* ; γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer, Immunity, 2014, 40(5): 785-800
PI: Lnc-DANCR-Akt/mTOR-Lin28 axis promotes breast cancer aromatase inhibitor resistance and the mechanism of stem cell characteristics, Zhejiang Provincial Natural Science Foundation of China, Outstanding Youth Project (LR19H160001), 2019.01-2023.12
PI: N2 polarization of neutrophils induced by exosome-STAT3 axis and positive feedback regulation mechanism of Tamoxifen-resistant breast cancer, National Natural Science Foundation of China, general program ,￥550,000, 2021.1-2024.12
PI: Mechanism of CD24+CD27+B cell direct contact pathway in the immune microenvironment of HER2+ breast cancer metastatic lymph nodes to promote tumor drug resistance and stemness, National Natural Science Foundation of China, general program ,￥550,000, 2023.1-2026.12
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