Yang Fuye, M.D., Ph.D.

Department:Nephrology

Medical School:The University of Hong Kong, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Immune-mediated glomerular diseases, including  glomerulonephritis, nephrotic syndrome, lupus nephritis and ANCA-associated kidney injury, tubulointerstitial disease, acute/chronic renal failure, peritoneal dialysis, etc.

Professional Highlights

Professional Appointments

Youth committee member, International Association of Translational Medicine Specialty Committee of Nephrology

Committee secretary, Zhejiang Preventive Medicine Association, Kidney Disease Prevention and Control Professional Committee


Education Experience

Ph.D., The University of Hong Kong (HKU), 2006-2009

Master, Fudan Univesity, 2002-2005

Bachelor, Jining Medical Colledge/Shandong University,1997-2002


Research Summary

Study the pathogenesis of renal inflammation and fibrosis by focusing on the role of macrophage.

Publications

Yang F,  Chen J, Huang XR, Yiu WH, Yu X, Tang SCW, Lan HY. Regulatory role and mechanisms of myeloid TLR4 in anti-GBM glomerulonephritis. Cellular and Molecular Life Sciences 2021;78(19-20):6721-6734.

Ni J#, Yang F#, Huang XR, Meng J,  Chen J, Bader  M, Penninger JM, Fung E, Yu X, Lan HY. Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. Journal of Cellular and Molecular Medicine. 2020;24(22):13093-13103. (Co-first author)

Yang F, Huang XR, Chung AC, Hou CC, Lai KN, Lan HY. Essential role for Smad3 in angiotensin II-induced tubular epithelial–mesenchymal transition. Journal of Pathology, 2010;221:390-401. 

Yang F, Chung ACK, Huang XR, Lan HY. Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor––Dependent and –Independent Smad Pathways: The Role of Smad3. Hypertension. 2009;54:877-884. 


Current Program

Role and mechanism of myeloid TLR4 in controlling peritoneal macrophage activity related with ongoing dialysate exposure. Funding Source: Zhejiang provincial natural science foundation (NO. Y24H050007), 01/2024-12/2027

Role and mechanism of macrophage in SGLT2 inhibitor to reduce renal fibrosis. Funding Source: Zhejiang Provincial Health Commission (NO. 2021KY702), 01/2021-01-12/2024



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