Chen Jinghai, Ph.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Researcher

Clinical / Research Interests

Molecular cardiology, cell biology, cardiac regeneration.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Dr. Chen's researches have been focused on cardiovascular diseases from development, adult heart remodeling and cardiac regeneration. Especially, Dr. Chen would like, but not limited, to elucidate how noncoding RNA regulates cardiac hypertrophy and cardiac regeneration during the cardiovascular diseases. Dr. Chen's team use cardiac cell system, mouse genetic model and AAV system to study the cardiovascular diseases. They apply a variety of molecular, cellular, and genetic approaches.


Wang F, Liu S, Pei J, Cai L, Liu N, Liang T, Dong X, Cong X, Chun J, Chen J*, Hu S*, Chen X*. LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice. Theranostics. 2020; 10(24): 10892-10907. 

Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, An P, Huang S, Pan J, Chen HZ, Chen J, Linkermann A, Min J, Wang F*. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.Fang X, Circulation Research. 2020 Jul 31;127(4):486-501. 

Zhang N, Zhu J, Ma Q, Zhao Y, Wang Y, Hu X, Chen J, Zhu W, Han Z, Yu H*. Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair. Stem Cell Res Ther. 2020 Jul 8;11(1):273. 

Zhang C, Lin Y, Liu Q, He J, Xiang P, Wang D, Hu X, Chen J, Zhu W, Yu H. Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis. J Cell Mol Med. 2020;24(15):8703-8717. 

Zhao Y, Zhu J, Zhang N, Liu Q, Wang Y, Hu X, Chen J, Zhu W, Yu H. GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing. Stem Cells Transl Med. 2020 Jun 9. doi: 10.1002/sctm.20-0005.

Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J,  Chen J* , Wang DZ*. Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nature Communications. 2019;10(1):1802.

Lv K, Li Q, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J, Hu X. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics. 2019;9(24):7403-7416. 

Qu X, Liu Y, Cao D, Chen J, Liu Z, Ji H, Chen Y, Zhang W, Zhu P, Xiao D, Li X, Shou W, Chen H. BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways. J Biol Chem. 2019 Dec 27;294(52):19877-19888. 

Wang Y, Xu Y, Wu C, Xia H, Wang Y, Nan J, Chen J, Yu H, Zhu W, Shi P, Daugherty A, Lu HS, Wang J. One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm. Biosci Rep. 2019 May 3;39(5). pii: BSR20182055.

Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA 2019 Feb 12;116(7):2672-2680.      

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J*, Hu X*. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circulation Research. 2018 Aug 17;123(5):564-578. 

Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J*. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis. 2018 May 1;9(5):556.

Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circulation Research. 2018 Mar 30;122(7):958-969. 

Zhu J, Lu K, Zhang N, Zhao Y, Ma Q, Shen J, Lin Y, Xiang P, Tang Y, Hu X, Chen J, Zhu W, Webster KA, Wang J, Yu H*. Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1659-1670. 

Zhou Y, Chen P, Liu Q, Wang Y, Zhang L, Wu R, Chen J, Yu H, Zhu W, Hu X, Wang JA*. Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury. Stem Cells Int. 2017:1096980. 

Hu H, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W*, Wang J*, Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci USA. 2017;114(45): 11908-11913.

Diniz GP, Huang ZP, Liu J, Chen J, Ding J, Fonseca RI, Barreto-Chaves ML, Donato J, Hu X, Wang DZ*. Loss of microRNA-22 prevents high fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy. Clin Sci (Lond). 2017 Nov 3. pii: CS20171368. doi: 10.1042/CS20171368.

Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A*. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 2017 Apr 10;6. pii: e24570. doi: 10.7554/eLife.24570.

Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J*. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Translational Medicine. 2017;6(1):209-222.

Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ*. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovascular Research. 2016;112:543–554.

Hu X, Xu Y, Zhong Z, Wu Y, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yang F, Jia L, Zhu W, Chen J, Yu H, Zhang J, Wang J*. A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-Human Primates: Paracrine Activity Without Remuscularization. Circulation Research. 2016;118(6):970-83.

Zhang N, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X, Wang J*. Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression. Biochim Biophys Acta. 2016;1863(12):3040-3049

Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ*. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. Journal of Clinical Investigation. 2015; 125(11):4122-34.

Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng ZL, Pu WT, Wang DZ*. Trbp regulates heart function through microRNA-mediated Sox6 repression.  Nature Genetics. 2015 ;47(7):776-83.

Prendiville TW, Guo H, Lin Z, Zhou P, Stevens SM, He A, VanDusen N, Chen J, Zhong L, Wang DZ, Gao G, Pu WT*. Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase. PLoS One. 2015;10(5):e0128105.

Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, Guo H, van Gorp PR, Wang DZ, Pu WT*. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circulation Research. 2015;116(1):35-45. 

Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C*. LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation,Apoptosis and Atherosclerosis by Enhancing p53 Activity. Circulation. 2014;130(17):1452-65. 

Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT*. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circulation Research. 2014 Jul 18;115(3):354-63.

Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT*. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 2014 Jun;20 (6):616-23.

Seok H#, Chen J#, Kataoka M, Huang ZP, Ding J, Yan J, Hu X, Wang DZ*. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circulation Research. 2014;114(10):1585-95. (# Co-first) 

Chen J, Huang ZP, Seok H, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu W, Liao R, Wang DZ*. mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts. Circulation Research. 2013; 112(12):1557-66. 

Huang ZP#, Chen J#, Seok H, Zhang Z, Kataoka M, Hu X, Wang DZ. MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress. Circulation Research. 2013 112(9):1234-43. (# Co-first)  

Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ*. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circulation Research. 2012; 110(6): 818-30. 

Chen J, Wang DZ*. microRNAs in cardiovascular development. Journal of Molecular and Cellular Cardiology. 2012;52(5):949-57. 

Chen J, Ortmeier SB, Savinova OV, Nareddy VB, Beyer AJ, Wang D, Gerdes AM*. Thyroid hormone induces sprouting angiogenesis in adult heart of hypothyroid mice through the PDGF-Akt pathway. Journal of Cellular and Molecular Medicine. 2012 16(11):2726-35. 

Chen J, Shearer GC, Chen Q, Healy CL, Beyer AJ, Nareddy VB, Gerdes AM, Harris WS, O'Connell TD, Wang D*. Omega-3 Fatty Acids Prevent Pressure Overload-Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts. Circulation. 2011;123(6):584-93. 

Deng L, Hu S, Baydoun AR, Chen J, Chen X, Cong X*. Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway. Cell Proliferation. 2009;42(6):721-30.

Shearer GC, Chen J, Chen Y, Harris WS*. Myocardial infarction does not affect fatty-acid profiles in rats. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2009;81:411-6.

Liu X, Hou J, Shi L, Chen J, Chen X, Sang J, Hu S, Cong X*. Lysophosphatidic acid protects mesenchymal stem cells against ischemia induced apoptosis in vivo. Stem Cells and Development. 2009;18(7):947-54

Xu RX, Chen X, Chen JH, Han Y, Han BM*. Mesenchymal stem cells promote cardiomyocyte hypertrophy in vitro through hypoxia-induced paracrine mechanisms. Clinical and Experimental Pharmacology and Physiology. 2009;36(2):176-80. 

Chen J, Baydoun AR, Xu R, Deng L, Zhu W, Cong X, Hu S, Chen X*. Lysophosphatidic Acid Protects Mesenchymal Stem Cells against Hypoxia and Serum Deprivation-Induced Apoptosis. Stem Cells. 2008;26(1):135-45. 

Chen J, Chen Y, Zhu W, Han Y, Han B, Xu R, Deng L, Cai Y, Cong X, Yang Y, Hu S, Chen Xi*.  Specific LPA receptor subtype mediation of LPA-induced hypertrophy of cardiac myocytes and involvement of Akt and NFkappaB signal pathways. Journal of Cellular Biochemistry. 2008;103(6):1718-31. 

Chen YF, Kobayashi S, Chen J, Redetzke RA, Said S, Liang Q, Gerdes AM*. Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Journal of Molecular and Cellular Cardiology. 2008;44(1):1

Xu R, Chen J, Cong X, Hu S, Chen X*. Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2. Journal of Cellular Biochemistry. 2008;103(1):256-69. 

Chen J, Han Y, Zhu W, Ma R, Han B, Cong X, Hu S, Chen X*. Specific receptor subtype mediation of LPA-induced dual effects in cardiac fibroblasts. FEBS Letters. 2006;580(19):4737-45.

Zhu W, Chen J, Cong X, Hu S, Chen X*. Hypoxia and serum deprivation induced apoptosis in mesenchymal stem cells. Stem Cells. 2006;24(2):416-25.

Current Program

Find People

Search by Family Name

Find A Department

Search by Departments