Department：Ultrasound Medicine
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Physician
Super-resolution ultrasound imaging, sonodynamic therapy, ultrasound artificial intelligence, ultrasound cavitation, immunity therapy, etc.
Advanced Worker, SAHZU, 2022
Postgraduate supervisor, Zhejiang University School of Medicine
Degree Program Secretary, Imaging Medicine and Nuclear Medicine Graduate Education Committee, Zhejiang University School of Medicine
Youth Member, Ultrasound Professional Committee of Chinese Society of Ultrasound Medical Engineering Molecular Imaging
Youth Member, Nano-Oncology Professional Committee of Chinese Anti-Cancer Association
Member, Youth Committee of Ultrasound Medicine Branch of Zhejiang Medical Association
Member, Youth Committee, Zhejiang Provincial Ultrasound Medical Engineering Society
Academic thesis instructor for undergraduate students majoring in clinical medicine, Zhejiang University School of Medicine.
M.D., Zhejiang University School of Medicine, 2018-2021;
Visiting Scholar, Department of Bioengineering, Imperial College London, 2019-2020;
M.S., Ningbo University School of Medicine, 2012-2016;
B.S., Ningbo University School of Medicine, 2003-2008.
In the past five years, Dr. Zhang has published 15 SCI papers as the first and corresponding author (including co-authors), hosted and participated in 4 National Natural Science Foundation projects, and applied for and obtained 16 authorized patents (including 2 US PCT patents).
Zhan Shi, Xue Wang, Jiali Luo, Yiqing Zeng, Qing Wen, Yurong Hong, Tao Zhang*, Pintong Huang*. RNA sequencing-based optimization of biological lipid droplets for sonodynamic therapy to reverse tumor hypoxia and elicit robust immune response [J]. Nano Research, 2023.
Xue Wang, Zhan Shi, Jiali Luo, Yiqing Zeng, Liangchan He, Libin Chen, Jianting Yao, Tao Zhang*, Pintong Huang*. Ultrasound improved immune adjuvant delivery to induce DC maturation and T cell activation[J]. Journal of Controlled Release, 2022, 349: 18-31.
Xue Wang, Jiali Luo, Jing Wang, Yu Sun, Jing Cao, Yiqing Zeng, Cong Zhang, Tao Zhang*, Pintong Huang*. Catalytically Active Metal Organic Frameworks elicit Robust Immune Response to Combination Chemodynamic and Checkpoint Blockade Immunotherapy [J]. ACS Applied Materials & Interfaces, 2022.
Jiali Luo, Jing Cao, Guangrong Ma, Xue Wang, Yu Sun, Cong Zhang, Zhan Shi, Yiqing Zeng, Tao Zhang*, Pintong Huang*. Collagenase-Loaded H-TiO2 Nanoparticles Enhance Ultrasound Imaging-Guided Sonodynamic Therapy in Pancreatic Carcinoma Xenograft Model via Digesting Stromal Barriers [J]. ACS Applied Materials & Interfaces, 2022.
Cong Zhang, Lei Xin, Jia Li, Jing Cao, Yu Sun, Xue Wang, Jiali Luo, Yiqing Zeng, Qunying Li, Ying Zhang, Tao Zhang*, Pintong Huang*. Metal-Organic Framework (MOF)-Based Ultrasound ‐ Responsive Dual-Sonosensitizer Nanoplatform for Hypoxic Cancer Therapy[J]. Advanced Healthcare Materials, 2022, 11(2): 2101946.
Jiali Luo, Xue Wang, Zhan Shi, Yiqing Zeng, Liangcan He, Jing Cao, Yu Sun, Tao Zhang*, Pintong Huang*. Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy[J]. Journal of Nanobiotechnology, 2022, 20(1): 1-17.
Jipeng Yan#, Tao Zhang#, Jacob Broughton-Venner, Pintong Huang*, Meng-Xing Tang*. Super-resolution ultrasound through sparsity-based deconvolution and multi-feature tracking[J]. IEEE Transactions on Medical Imaging, 2022.
Tao Zhang#, Yu Sun, Jing Cao, Jiali Luo, Jing Wang, Zhenqi Jiang*, Pintong Huang*. Intrinsic nucleus-targeted ultra-small metal–organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma[J]. Journal of nanobiotechnology, 2021, 19(1): 1-14.
Tao Zhang#, Bihan Wu#, Ozioma Udochukwu Akakuru, Chenyang Yao, Shan Sun, Libin Chen, Wenzhi Ren*, Aiguo Wu*, Pintong Huang*. Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer[J]. Cancer Letters, 2021, 500: 41-50.
Yu Sun#, Jing Cao#, Xue Wang, Cong Zhang, Jiali Luo, Yiqing Zeng, Chao Zhang, Qunying Li, Ying Zhang, Wen Xu, Tao Zhang*, Pintong Huang*. Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal–Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator[J]. ACS Applied Materials & Interfaces, 2021, 13(32): 38114-38126.
Jing Cao#, Yu Sun#, Cong Zhang, Xue Wang, Yiqing Zeng, Tao Zhang*, Pintong Huang*. Tablet-like TiO2/C nanocomposites for repeated type I sonodynamic therapy of pancreatic cancer[J]. Acta Biomaterialia, 2021, 129: 269-279.
Xiao Han#, Zeyu Song, Ying Zhou, Yujing Zhang, Yulin Deng, Jieling Qin, Tao Zhang*, Zhenqi Jiang*.Mitochondria-targeted high-load sound-sensitive micelles for sonodynamic therapy to treat triple-negative breast cancer and inhibit metastasis[J]. Materials Science and Engineering: C, 2021, 124: 112054.
Libin Chen#, Tao Zhang#, Shan Sun, Wenzhi Ren, Aiguo Wu*, Huixiong Xu*. Ultrasound-mediated cavitation enhances EGFR-targeting PLGA-PEG nano-micelle delivery for triple-negative breast cancer treatment[J]. Cancers, 2021, 13(14): 3383.
Tao Zhang#, Zhenqi Jiang, Libin Chen, Chunshu Pan, Shan Sun, Chuang Liu, Zihou Li, Wenzhi Ren*, Aiguo Wu*, Pintong Huang*. PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia[J]. Nano Research, 2020. 13(1): p. 273-281.
Tao Zhang#, Zhenqi Jiang, Ting Xue, Shan Sun, Juan Li, Wenzhi Ren*, Aiguo Wu*, Pintong Huang*. One-pot synthesis of hollow PDA@DOX nanoparticles for ultrasound imaging and chemo-thermal therapy in breast cancer. Nanoscale, 2019. 11(45): p. 21759-21766.
Research on visualizing the course of type 2 diabetes based on ultrasonic positioning microscopy technology. Funding Source: National Natural Science Foundation of China (82371968), 2024-2027.
Experimental study on the reversal of multidrug resistance in breast cancer using ultrasound-mediated functional lipid droplet sonodynamic therapy. Funding Source: National Natural Science Foundation of China (82230069), 2023-2027.
Research on mitochondria-targeted bionic sonodynamics combined with immune checkpoint blockade for breast cancer treatment. Funding Source: National Natural Science Foundation of China (32201138), 2023-2025.
Ultra-high frame rate microvascular imaging to visually evaluate the impact of ultrasound-mediated targeted CD39 nanobubble cavitation on the immune microenvironment of pancreatic cancer. Funding Source: National Natural Science Foundation of China(82030048), 2021-2025.
88 Jiefang Road,Shangcheng District Hangzhou,China, 310009
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Zijingang Campus of Zhejiang University, 866 Yuhangtang Road, Xihu District, Hangzhou
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Zhejiang University School of Medicine
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iao_sahzu@zju.edu.cn
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