Nan Jinliang, M.D., Ph.D.

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician

Appointment

Clinical / Research Interests

Dr. Nan's primary interests lie in the field of cardiovascular medicine, with a particular focus on interventional treatment of coronary artery disease.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Dr. Nan's research focuses on mitochondrion and endoplasmic reticulum in myocardial cell survival, and the underlying pathology of coronary artery disease and heart failure.

Publications

Lv X#, Cong X#, Nan J#, Lu X#, Zhu Q, Shen J, Wang B, Wang Z, Zhou R, Chen W, Su L, Chen X, Li Z, Lin Y*. Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice. Acta Pharmacol Sin, 2022 25.

Nan J#, Li J, Lin Y, Saif Ur Rahman M, Li Z, Zhu L*. The interplay between mitochondria and store-operated Ca 2+ entry: Emerging insights into cardiac diseases*. J Cell Mol Med, 2021, 25(20):9496-9512.

Zhang L#, Liu G, Lv K, Xin J, Wang Y, Zhao J, Hu W, Xiao C, Zhu K, Zhu L, Nan J, Feng Y, Zhu H, Chen W, Zhu W, Zhang J, Wang J, Wang B, Hu X*. Surface-Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine-Receptor Binding Pathways. Adv Sci, 2021, 6;8(3): 2003348.

Lin Y#, Nan J#, Shen J#, Lv X, Chen X, Lu X, Zhang C, Xiang P, Wang Z*, Li, Z*. Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells. EBioMedicine. 2020;52:102637.

Nan J#, Nan C, Ye J, Qian L, Geng Y, Xing D, Rahman MSU, Huang M*. EGCG protects cardiomyocytes against hypoxia-reperfusion injury through inhibition of OMA1 activation. J Cell Sci, 2019, 132(2):

Li Z#, Zhang C, Wang Z, Shen J, Xiang P, Chen X, Nan J*, Lin Y*. Lipofectamine 2000/siRNA complexes cause endoplasmic reticulum unfolded protein response in human endothelial cells. J Cell Physiol 2019, 234(11): 21166-21181.

Wang Y#, Xu Y, Wu C, Xia H, Wang Y, Nan J, Chen J, Yu H, Zhu W, Shi P, Daugherty A, Lu HS, Wang J*. One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm. Biosci Rep, 2019, 3;39(5): BSR20182055.

Yang F#, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J*. (2018). Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis 9, 556.

J Nan#, H Hu#, Y Sun#, L Zhu, Y Wang, Z Zhong, J Zhao, N Zhang, Y Wang, Y Wang, J Ye, L Zhang, X Hu, W Zhu, J Wang*, TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circulation research, 2017, 121: 392-410.

H Hu#, J Nan#, Y Sun#, D Zhu, C Xiao, Y Wang, L Zhu, Y Wu, J Zhao, R Wu, J Chen, H Yu, W Zhu, J Wang*, Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. PNAS, 2017, 114: 11908-11913.

J. Nan#, W. Zhu, M.S. Rahman, M. Liu, D. Li, S. Su, N. Zhang, X. Hu, H. Yu, M.P. Gupta, J. Wang*, Molecular regulation of mitochondrial dynamics in cardiac disease, Biochimica et biophysica acta, 2017, 1864: 1260-1273.

Zhang N#, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X, Wang J*. Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression, Biochimica et biophysica acta, 1863 (2016) 3040-3049.

Ji K#, Qian L, Nan J, Xue Y, Zhang S, Wang G, Yin R, Zhu Y, Wang L, Ma J, Liao L, Tang J*. Ox-LDL induces dysfunction of endothelial progenitor cells via activation of NF-κB. Biomed Res Int, 2015;2015:175291.

Qian L#, Ji K, Nan J, Lu Q, Zhu Y, Wang L, Liao L, Tang J*. Factors associated with decision time for patients with ST-segment elevation acute myocardial infarction. J Zhejiang Univ Sci B, 2013 Aug;14(8):754-8.

Ji K#, Xing C, Jiang F, Wang X, Guo H, Nan J, Qian L, Yang P, Lin J, Li M, Li J, Liao L, Tang J*. Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway. Int J Mol Med, 2013 Apr;31(4):922-30.

Ji K#, Chai J, Xing C, Nan J, Yang P, Tang J*. Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment. J Zhejiang Univ Sci B, 2010 Aug;11(8):618-26.



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