Publications

Dong J#, Zhong T#, Xu Z, Chen H, Wang X, Yang L, Lou Z, Xu Y, Hou T, Xu R, Zhu W*, Shao J*. Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model. Cancers (Basel). 2022 Sep 27;14(19):4710.

Xie Y#, Wang Y#, Xu Z#, Lu Y#, Song D, Gao L, Yu D, Li B, Chen G, Zhang H, Feng Q, Zhang Y, Hu K, Huang C, Peng Y, Wu X, Mao Z, Shao J*, Zhu W*, Shi J*. Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma. Journal of Biomedical Science. 2022 May 12; 29(1):32. doi: 10.1186/s12929-022-00813-2.

Liu Q, Guo L, Lou Z, Xiang X*, Shao J*. Super-enhancers and novel therapeutic targets in colorectal cancer. Cell Death Dis. 2022 Mar 11;13(3):228. doi: 10.1038/s41419-022-04673-4.

Shao Y#, Xu K#, Zheng X, Zhou B, Zhang X, Wang L, Sun Y, Li D, Chen T, Wang J, Yu S, Sun L, Xu X, Dai S, Gao H, Ruan G, Liu W, Cai X, Zhu T, Qi L, Chen J, Hu W, Weng X, Zhu Y, Xiang X, Hu Z, Li J, Chen L, Shao J*, Zheng S*, Guo T*. Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target. Cancer Communications. 2022 Feb;42(2):164-169.

Liu Q, Guo L, Qi H, Lou M, Wang R, Hai B, Xu K, Zhu L, Ding Y, Li C, Xie L, Shen J, Xiang X*, Shao J*. A MYBL2 complex for RRM2 transactivation and the synthetic effect of MYBL2 knockdown with WEE1 inhibition against colorectal cancer. Cell Death Dis. 2021 Jul 7;12(7):683. doi: 10.1038/s41419-021-03969-1.

Wang R, Xu Z, Tian J, Liu Q, Dong J, Guo L, Hai B, Liu X, Yao H, Chen Z, Xu J, Zhu L, Chen H, Hou T, Zhu W*, Shao J*. Pterostilbene inhibits hepatocellular carcinoma proliferation and HBV replication by targeting ribonucleotide reductase M2 protein. American Journal of Cancer Research.2021 Jun 15;11(6):2975-2989.

Han Q, Li H, Jia M, Wang L, Zhao Y, Zhang M, Zhang Q, Meng Z, Shao J*, Yang Y*, Zhu L*. Age-related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats. Aging Cell. 2021 Jun 22;e13425. doi: 10.1111/acel.13425. Online ahead of print.

Tang Q, Wu L, Xu M, Yan D, Shao J*, Yan S*. Osalmid, a novel identified RRM2 inhibitor, enhances radiosensitivity of esophageal cancer. Int J Radiat Oncol Biol Phys. 2020 Aug 4. Online ahead of print.

Qi H, Yang Z, Dai C, Wang R, Ke X, Zhang S, Xiang X, Chen K, Li C, Luo J, Shao J*, Shen J*. STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis. Oncogenesis, 9 (2), 15, 2020 Feb 10.

Zejun Fang, Hua Yang, Dan Chen, Xiaoying Shi, Qinqiu Wang, Chaoju Gong, Xi Xu, Hong Liu, Min Lin, Junxiao Lin, Chengfu Xu*, Jimin Shao*. YY1 Promotes Colorectal Cancer Proliferation Through the miR-526b-3p/E2F1 Axis.American Journal of Cancer Research, 2019 Dec 1，9 (12), 2679-2692.

Ding Y, Zhong T, Wang M, Xiang X, Ren G, Jia Z, Lin Q, Liu Q, Dong J, Li L, Li X, Jiang H, Zhu L, Li H, Shen D, Teng L*, Li C*, Shao J*. Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. Frontiers in Oncology. 2019;9:956.

Wang T, Song P, Zhong T, ..., Fodde R*, Shao J*. The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties. Oncogene. 2019 Feb 25 [Epub ahead of print]

Shao Y, Chen T, Zheng X,..., Shao J*, Zheng S*. Colorectal cancer-derived small extracellular vesicles establish an inflammatory pre-metastatic niche in liver metastasis. Carcinogenesis. 2018 Sep 4. [Epub aheadofprint] 

Shen J, Xiang X, Chen L, Wang H, Wu L, Sun Y, Ma L, Gu X, Liu H, Wang L, Yu YN, Shao J*, Huang C*, Chin YE*. JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress. EMBO Rep. 2017 Oct 5. [Epub ahead of print]

Lou M, Liu Q, Ren G, Zeng J, Xiang X, Ding Y, Lin Q, Zhong T, Liu X, Zhu L, Qi H, Shen J, Li H, Shao J*. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Apr 14. pii: jbc.M117.783365. doi: 10.1074/jbc.M117.783365. [Epub ahead of print].

Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL*, Stubbe J*. Glutamate 52-β at the α/β Subunit Interface of E. coli Class Ia Ribonucleotide Reductase is essential for Conformational Gating of Radical Transfer. J Biol Chem. 2017 Apr 4. pii: jbc.M117.783092. doi: 10.1074/jbc.M117.783092. [Epub ahead of print].

Ravichandran KR, Minnihan EC, Lin Q, Yokoyama K, Taguchi AT, Shao J, Nocera DG*, Stubbe J*. Glutamate 350 plays an essential role in conformational gating of long range radical transport in E. coli class Ia ribonucleotide reductase. Biochemistry. 2017 Jan 19. doi: 10.1021/acs.biochem.6b01145. [Epub ahead of print].

Chaoju Gong, Hong Liu, Rui Song, Tingting Zhong, Meng Lou, Tingyang Wang, Hongyan Qi, Jing Shen, Lijun Zhu, Jimin Shao*. ATR-CHK1-E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG. BBA - Gene Regulatory Mechanisms. 2016; 1859(4):612–626.

Liu X, Xu Z, Hou C, Zhu L, Qiu Y, Chen Z, Yang C*, Zhu W*, Shao J*. Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. Biochemical Pharmacology. 2016;103:118-128.

Yao C, Su L, Shan J, Zhu C, Liu L, Liu C, Xu Y, Yang Z, Bian X, Shao J, Li J, Lai M, Shen J, Qian C*. IGF/STAT3/NANOG/Slug signaling axis simultaneously controls epithelial-mesenchymal transition and stemness maintenance in colorectal cancer. Stem Cells. 2016;34(4):820-31.

Cheng F, Su L, Yao C, Liu L, Shen J, Liu C, Chen X, Luo Y, Jiang L, Shan J, Chen J, Zhu W, Shao J, Qian C*. SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. Cancer Letters. 2016;375(2):274-83

Hong Liu, Guoping Ren, Tingyang Wang, Yuexia Chen, Chaoju Gong, Yanfeng Bai, Bo Wang, Hongyan Qi, Jing Shen, Lijun Zhu, Cheng Qian, Maode Lai, Jimin Shao*. Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition. Carcinogenesis. 2015;36(4):459-68.

Hongyan Qi, Meng Lou, Yuexia Chen, Xiyong Liu, Naiming Chen, Jianzhen Shan, Zhiqiang Ling, Jing Shen, Lijun Zhu, Yun Yen, Shu Zheng*, Jimin Shao*. Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis. Tumor Biology. 2015 Jun;36(6):4833-42.

Fang Z, Song R, Gong C, Zhang X, Ren G, Li J, Chen Y, Qiu L, Mei L, Zhang R, Xiang X, Chen X, Shao J*. Ribonucleotide reductase large subunit M1 plays a different role in the invasion and metastasis of papillary thyroid carcinoma and undifferentiated thyroid carcinoma. Tumor Biology. 2015 Oct 9. [Epub ahead of print].

Huang X, Zhang S, Qi H, Wang Z, Chen HW, Shao J*, Shen J*. JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation. Biochim Biophys Acta. 2015;1853(10 Pt A):2286-2295.

Wei X, Liu L, Wang G, Li W, Xu K, Qi H, Liu H, Shen J, Li Z, Shao J*. Potent antitumor activity of the Ad5/11 chimeric oncolytic adenovirus combined with interleukin-24 for acute myeloid leukemia via induction of apoptosis. Oncology Reports 2015 Jan; 33(1): 111-8.

Wang J, Lin D, Peng H, Shao J*, Gu J*. Cancer-derived immunoglobulin G promotes LPS-induced proinflammatory cytokine production via binding to TLR4 in cervical cancer cells. Oncotarget. 2014，5（20）：9727-9743.

Chen X, Xu Z, Zhang L, Liu H, Liu X, Lou M, Zhu L, Huang B, Yang C, Zhu W*, Shao J*. The conserved Lys95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2. J Biol Chem. 2014;289(2):909-20.

Wei X, Liu L, Wang G, Li W, Xu K, Hu X, Qian C, Shao J*. Targeting eradication of chronic myeloid leukemia using chimeric oncolytic adenovirus to drive IL-24 expression. Int J Clin Exp Pathol. 2015 Apr 1;8(4):3775-84.

Shao J, Liu X, Zhu L, Yen Y. Targeting ribonucleotide reductase for cancer therapy. Expert Opinion On Therapeutic Targets. 2013;17 (12):1423-37.

Huang X, Zhang L, Qi H, Shao J*, Shen J*. Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5. Biochimie. 2013;95(11):2114-22.

Jin G, Zhao J, Qi H, Lou M, Liu X, Qu Y, Zhao L, Zhang W, Shao J*, Zhong H*. Gemcitabine and carboplatin demonstrate synergistic cytotoxicity in cervical cancer cells by inhibiting DNA synthesis and increasing cell apoptosis. OncoTargets and Therapy. 2013;6:1707–1717.

Qi H, Zhu H, Lou M, Fan Y, Liu H, Shen J, Li Z, Lv X, Shan J, Zhu L, Chin YE*, Shao J*. Interferon regulatory factor1 transactivates the expression of human DNA polymerase η in response to the carcinogen N-methyl-N’-nitro-N-nitrosoguanidine. J Biol Chem. 2012;287(16):12622-33. 

Zhu H, Fan Y, Shen J, Qi H, Shao J*. Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide. Environmental Toxicology and Pharmacology, 2012; 33(2): 205-211.

Wang Q, Jiang H, Fan Y, Huang X, Shen J, Qi H, Li Q, Lu X, Shao J*. Phosphorylation of the α-subunit of the Eukaryotic Initiation Factor-2 (eIF2α) alleviates benzo(a)pyrene-7,8-diol-9,10-epoxide induced cell cycle arrest and apoptosis in human cells. Environmental Toxicology and Pharmacology 2011;31(1):18-24.

Zhu H, Fan Y, Jiang H, Shen J, Qi H, Mei R, Shao J*. Response of human DNA polymerase promoter to N-methyl-N'-nitro-N-nitrosoguanidine. Environmental Toxicology and Pharmacology 2010;29 (1) :79–86.

Lu X#, Shao J#, Li H, Yu Y. Temporal gene expression changes induced by a low concentration of benzo[a]pyrene diol epoxide in a normal human cell line. Mutation Research 2010;684(1-2):74-80.