Department：Breast Surgery
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Associate Chief Physician
Breast disease, including surgical and comprehensive treatment of breast cancer and benign breast tumors.
Zhejiang Province High-Level Healthcare Talent (2023),
Recipient of the Zhejiang Province Association for Science and Technology's Youth Talent Support Program (2023)
Zhijiang Outstanding Young Scholar of the Zhejiang Province Immunology Society (2023)
Deputy Director, Youth Committee of Oncology Physicians Branch, Zhejiang Medical Association
Member, American Society of Clinical Oncology
Member, Chinese Society of Clinical Oncology
Youth Member of the Clinical Immunology Professional Committee, Zhejiang Provincial Immunological Society
Member of the Committee for the Prevention, Treatment and Education of Chronic Diseases in Traditional Chinese Medicine, Chinese Medical Education Association
Ph.D. in Oncology, Zhejiang University School of Medicine, China, 2015-2018
M.D. in Clinical Medicine, Zhejiang University School of Medicine, China, 2008-2015
Dr. Wang has been engaged in research related to the tumor immune microenvironment and the pre-metastatic niche for nearly 10 years, with a focus on myeloid cells (including neutrophils, macrophages, and MDSCs). The aim is to explore the underlying mechanisms of tumor recurrence, metastasis, and drug resistance, and to provide new therapeutic strategies for cancer from an immunological perspective. The applicant has published several original research findings on macrophages, neutrophils, and MDSCs in professional journals such as Cell Metabolism, Immunity, Gut, Journal for ImmunoTherapy of Cancer, Advanced Science, Oncogenesis, Frontiers in Immunology, and Cancer Letters.
Yang, C., Li, L., Ye, Z., Zhang, A., Bao, Y., Wu, X., Ren, G., Jiang, C., Wang, O.#, and Wang, Z.# (2024). Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression. Cell Commun Signal 22, 340. 10.1186/s12964-024-01716-5.
Zhang, Z., Yang, C., Li, L., Zhu, Y., Su, K., Zhai, L., Wang, Z.#, and Huang, J#. (2021). "γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy. Front Immunol 12, 699478. 10.3389/fimmu.2021.699478.
Yang, C.*, Wang, Z.*, Li, L.*, Zhang, Z., Jin, X., Wu, P., Sun, S., Pan, J., Su, K., Jia, F., et al. (2021). Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer 9. 10.1136/jitc-2021-002875.
Wang, Z.*, Yang, C.*, Li, L., Jin, X., Zhang, Z., Zheng, H., Pan, J., Shi, L., Jiang, Z., Su, K., et al. (2020). Tumor-derived HMGB1 induces CD62L(dim) neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis 9, 82. 10.1038/s41389-020-00267-x.
Morrissey, S.M., Zhang, F., Ding, C., Montoya-Durango, D.E., Hu, X., Yang, C., Wang, Z., Yuan, F., Fox, M., Zhang, H.G., et al. (2021). Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell Metab 33, 2040-2058.e2010. 10.1016/j.cmet.2021.09.002.
National Natural Science Foundation of China, "Mechanism of estrogen reshapes the adipose tissue immune microenvironment to promote metastasis of triple-negative breast cancer", Ongoing, Principal Investigator, 01/2023-12/2026
Zhejiang Medicine and Health Science and Technology Project, "Mechanism of tumor-infiltrating neutrophils mediating the PKM2 signaling pathway to regulate the metabolic reprogramming of tumor cells to promote triple-negative breast cancer progression", Ongoing, Principal Investigator, 01/2024-12/2026
Chinese Society of Clinical Oncology (CSCO) Foundation, "Function of breast-specific gamma-imaging in efficacy prediction of breast cancer neoadjuvant chemotherapy", Ongoing, Principal Investigator. 01/2024-12/2026
Young Elite Scientists Sponsorship Program by Zhejiang Association for Science and Technology, "Tumor Immunology", Ongoing, Principal Investigator, 01/2023-12/2025
88 Jiefang Road,Shangcheng District Hangzhou,China, 310009
1511 Jianghong Road,Binjiang District Hangzhou,China, 310014
300 Yuanju Road, Shangcheng DIstrict, Hangzhou
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1 Xihu Avenue, Shangcheng District, Hangzhou
Zijingang Campus of Zhejiang University, 866 Yuhangtang Road, Xihu District, Hangzhou
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Zhejiang University School of Medicine
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iao_sahzu@zju.edu.cn
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