Zhang Zhaocai, M.D., Ph.D.

Department:Intensive Care Unit

Medical School:Fudan University, China

Academic Rank:Chief Physician


Clinical / Research Interests

Sepsis, septic shock, multiple organ dysfunction syndrome, malnutrition due to critical illness, fulminant myocarditis, end-stage heart failure.

Professional Highlights

Zhejiang Medical and Health Science Innovation Award, First Prize

Zhejiang Medical and Health Science Innovation Award, Second Prize

Zhejiang Scientific and Technological Progress Award, Third Prize

Professional Appointments

Deputy Head, Clinical Research Group, Emergency Medicine Branch, Chinese Medical Association, 2017-present

Standing Member, Hospital Scientific Research Management Branch, Zhejiang Medical Association, 2019-present

Member, Clinical Epidemiology and Evidence-based Medicine Branch, Zhejiang Medical Association, 2019-present

Member, Rare Diseases Branch, Zhejiang Medical Association, 2018-present

Program Director of the Emergency and Critical Medicine, Department of Medical Science, National Natural Science Foundation of China, 2015-2017

Expert in Medical Malpractice Appraisal, Chinese Medical Association, 2018-present 

Review Expert, National Natural Science Foundation of China, 2017-present

Education Experience

Research Summary

Dr. Zhang has been engaged in the basic and clinical research of sepsis related myocardial dysfunction (SRMD) for more than 10 years and has been received two grants (No.81471889 and No.81772110) from the National Natural Science Foundation of China (NSFC) and several research projects (general and key projects) from Zhejiang Province. The research team of Dr. Zhang was committed to the discovery of biomarkers and intervention targets for the diagnosis and prognosis of SRMD, and to explore the cellular and molecular mechanisms and mitochondrial mechanisms for protection of SRMD.


Xu Y, Rong J, Zhang Z*. The emerging role of angiotensinogen in cardiovascular diseases. J Cell Physiol. 2020;10.1002/jcp.29889. doi:10.1002/jcp.29889.

Xu Y, Zhang S, Rong J, Lin Y, Du L, Wang Y*, Zhang Z*. Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle. Pharmacol Res. 2020;159:104887. doi:10.1016/j.phrs.2020.104887.

Lin Y, Xu Y, Zhang Z*. Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria. Inflammation. 2020;10.1007/s10753-020-01233-w. doi:10.1007/s10753-020-01233-w.

Yang H, Du L, Zhang Z*. Potential biomarkers in septic shock besides lactate. Exp Biol Med (Maywood). 2020;1535370220919076. doi:10.1177/1535370220919076.

Chen F, Xu Y, Zhang Z*. Multi-biomarker strategy for prediction of myocardial dysfunction and mortality in sepsis. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2020 21(7):1-12 doi:.10.1631/jzus.B2000049.

Chen J, Wang Y, Hu X; Li M, Wu J, Yang J, Xiong K, Zhang Z*, Chen Q*, The role of statins in the management of delirium: Recent advances. CNS & Neurological Disorders - Drug Targets. July, 2020.

Tao XR, Rong JB, Lu HS, Daugherty A, Shi P, Ke CL, Zhang ZC, Xu YC*, Wang JA*. Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. J Lipid Res. 2019 Dec;60(12):1983-1995. doi: 10.1194/jlr.M093252.

Liu Q, Zhang L, Shan Q, Ding Y, Zhang Z, Zhu M, Mao Y*. Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway. J Int Med Res. 2018;46(6):2096-2103. doi:10.1177/0300060517717358.

Peng K, Qiu Y, Li J, Zhang ZC, Ji FH*. Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes. Exp Ther Med. 2017;14(1):689-695. doi:10.3892/etm.2017.4537.

Peng K, Liu HY, Wu SR, Liu H, Zhang ZC, Ji FH*. Does Propofol Anesthesia Lead to Less Postoperative Pain Compared With Inhalational Anesthesia?: A Systematic Review and Meta-analysis. Anesth Analg. 2016;123(4):846-858. doi:10.1213/ANE.0000000000001504.

Zhang Z*, Dai H, Yu Y, Yang J, Chen J, Wu L. Elevated pregnancy-associated plasma protein A predicts myocardial dysfunction and death in severe sepsis. Ann Clin Biochem. 2014;51(Pt 1):22-29. doi:10.1177/0004563213489275.

Zhang Z, Wang JA*, Xu Y, et al. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction. Int J Cardiol. 2013;168(2):1711-1714. doi:10.1016/j.ijcard.2013.03.126.

Zhang ZC*, Dai HW, Yu YH, Yang JD, Hu CB. Usefulness of heart-type fatty acid-binding protein in patients with severe sepsis. J Crit Care. 2012;27(4):415.e13-415.e4.15E18. doi:10.1016/j.jcrc.2012.01.004.

Current Program

Mitochondrial mechanism of integrin β 1 mediated protection of septic heart in rats. Funding Source: National Natural Science Foundation of China. 

Cellular and molecular mechanisms of β 1 integrin mediated protection against sepsis induced myocardial injury. Funding Source: National Natural Science Foundation of China. 

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