Research Summary

In the early 1990s, under the support of the National Natural Science Foundation of China, Dr. Chen conducted the research project of periodontal subcellular structural lesions and bone resorption activity of porphyromonas gingivalis endotoxin (project no.: 39300145), and investigated the suspicious periodontal pathogens and endotoxin molecular biology. The research found that "Pg-LPS can not only directly promote bone resorption, but induce human peripheral blood mononuclear cells to produce IL-1, TNF and other inflammatory factors to promote bone resorption. This finding was awarded the second prize of Professional Award for Science and Technology Advancement of Zhejiang Province.

With the support of the National Natural Science Foundation of China, Dr. Chen continued to study the signal transduction pathways and regulation mechanisms of Pg-LPS introduced inflammation of different cells in periodontal tissue (project no.: 30471888). The research result about the relationship between the occurrence of periodontitis and suspicious periodontal pathogens and their genotypes, won the third prize of Professional Award for Science and Technology Advancement of Zhejiang Province in 2007.

With the support of the National Natural Science Foundation of China, the significance of osteoclast secretion function on osteoblasts and related signal regulation in alveolar bone resorption and reconstruction is also one project of Dr. Chen's (project no.: 30872884). The research result shows the molecular mechanism of alveolar bone regeneration in periodontal inflammatory environment, which won the third prize of Professional Award for Science and Technology Advancement of Zhejiang Province in 2014.

Currently, Dr. Chen is studying the discrepant effect of different phenotypes of Th17 cells and their characteristic secretion on alveolar bone destruction, which is funded by the National Natural Science Foundation of China (project no.: 81771072), and looking into the development and application of a new periodontal soft and hard tissue regeneration complex, which is funded by the Key Project of Science and Technology of Zhejiang (project no.: 2019C03027). Dr. Chen is engaged in the research of the pathogenesis of periodontal disease and the molecular mechanism of inflammatory alveolar bone destruction as well as the development and application of periodontal soft and hard tissue regeneration.