Chen Linwei, M.D., Ph.D.


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician, Associate Professor


Clinical / Research Interests

Spine surgery, including fractures, degenerations, infections, malformations and tumors; trauma in the four limbs; osteoporosis.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Epigenetic change of bone marrow stem cells in osteoporosis; epigenetic change of chondrocytes in osteoarthritis.


Chen L, Wu Y, Wu Y, Wang Y, Sun L, Li F. The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway. Sci Rep. 2016 Aug 19;6:29176. 

Wu Y,  Chen L, Wang Y, Li W, Lin Y, Yu D, Zhang L, Li F, Pan Z. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-kappaB mediated inflammatory responses in osteoarthritis development. Scientific reports. 2015;5:17602.

Chen L, Yang X, Huang G, Song D, Ye XS, Xu H, Li W. Platelet-rich plasma promotes healing of osteoporotic fractures. Orthopedics. 2013;36(6):e687-94.

Chen L, Ouyang Y, Huang G, Lu X, Ye XS, Hong J. Endobutton technique for dynamic fixation of traumatic symphysis pubis disruption. Acta orthopaedica Belgica. 2013;79(1):54-9.

Chen L, Lu X, Li S, Sun Q, Li W, Song D. Sustained delivery of BMP-2 and platelet-rich plasma-released growth factors contributes to osteogenesis of human adipose-derived stem cells. Orthopedics. 2012;35(9):e1402-9.

Chen L, Zhang G, Song D, Guo X, Yuan W. A comparison of percutaneous reduction and screw fixation versus open reduction and plate fixation of traumatic symphysis pubis diastasis. Archives of orthopaedic and trauma surgery. 2012;132(2):265-70.

Chen L, Zhang G, Li S, Wu Z, Yuan W, Hong J. Percutaneous treatment of calcaneus fractures associated with underlying bone cysts. Foot & ankle international. 2012;33(5):424-9.5.                                                                                                   

Chen L, Zhang G, Wu Y, Guo X, Yuan W. Percutaneous limited internal fixation combined with external fixation to treat open pelvic fractures concomitant with perineal lacerations. Orthopedics. 2011;34(12):e827-31.

Chen L, Zhang G, Hong J, Lu X, Yuan W. Comparison of percutaneous screw fixation and calcium sulfate cement grafting versus open treatment of displaced intra-articular calcaneal fractures. Foot & ankle international. 2011;32(10):979-85.

Current Program

The role of KDM and KMT in the control of the imbalance of osteogenic and adipogenic differentiation of aged BMSC. Funding Source: National Natural Scientific Foundation of China.

The role of KDM6B in the intervertebral disk degeneration by epigenetically regulating the expression of RUNX2. Funding Source: National Natural Scientific Foundation of Zhejiang.

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