Zhou Quan, Ph.D.

Position:Vice Chair of Pharmacy


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Pharmacist

Clinical / Research Interests

Clinical pharmacy, medication therapy management, and quality management.

Professional Highlights

Zhejiang Provincial Professional Award for Science and Technology Innovation, Second Prize

Zhejiang Provincial Award for Pharmaceutical Administration Innovation

Professional Appointments

Vice President, Zhejiang Society of Licensed Pharmacists, 2016- present 

Committee Member, Zhejiang Hospital Pharmacy Society

Committee Member, Zhejiang Pharmaceutical Administration Society

Committee Member, Zhejiang Cancer Pain Society

Member, Medical Science Popularization Committee, Zhejiang Medical Society

Education Experience

Research Summary

Clinical pharmacy on drug metabolism and transporters, herb-drug interaction, drug-drug interaction, food-drug interaction, medication errors, pharmacological nursing, quality management, adverse drug reactions, medication therapy management.


Zhu LL, Zhou Q (corresponding author). Optimal infusion rate in antimicrobial therapy explosion of evidence in the last five years.Infect Drug Resist. 2018 Aug 8;11:1105-1117. 

Chen M, Zhou SY, Fabriaga E, Zhang PH, Zhou Q (corresponding author). Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review.J Food Drug Anal. 2018 Apr;26(2S):S61-S71. 

Feng XQ, Zhu LL, Zhou Q (corresponding author). Opioid analgesics related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.J Pain Res,2017 May 24;10:1225-1239.

ZHOU Quan, YU Lu-shan, ZENG Su. Personalized dosing from perspective of pharmacogenomics of drug metabolizing enzymes and transporters. Acta Pharmaceutica Sinica, 2017, 52(1): 1-7.

Chen QL, Zhao XY, Wang XM, Lv N, Zhu LL, Xu HM, Zhou Q (corresponding author). Retrospective analysis of non-laboratory-based adverse drug reactions induced by intravenous radiocontrast agents in a Joint Commission International-accredited academic medical center hospital in China.Ther Clin Risk Manag. 2017; 13:565-573.

Xiu-lai Zhang, Meng Chen, Ling-ling Zhu, and Quan Zhou (corresponding author) .Therapeutic Risk and Benefits of Concomitantly Using Herbal Medicines and Conventional Medicines: From the Perspectives of Evidence Based on Randomized Controlled Trials and Clinical Risk Managemen. Evid Based Complement Alternat Med. 2017;2017:9296404.

Feng XQ, Zhu LL, Zhou Q (corresponding author). The checking methods before medication administration: A perspective from a Joint Commission International-accredited academic medical center hospital in China. J Eval Clin Pract. 2017;23(3):676-678. 

Zhu LL, Zhou Q (corresponding author). Multidisciplinary collaboration among physicians, pharmacists, nurses, and information technology engineers addresses inappropriate pill crushing and capsule opening in hospitalized patients. Int J Nurs Pract. 2016 Dec;22(6):660-661.

Zhu LL, Lv N, Zhou Q (corresponding author). Response to "Improving Patient Safety With Error Identification in Chemotherapy Orders by Verification Nurses". Clin J Oncol Nurs. 2016 Dec 1;20(6):581-582.

Zhu LL, Zhou Q (corresponding author). Quality improvements in potassium replenishment in intensive critical care units.Intensive Crit Care Nurs. 2016 Oct;36:24-5. 

Zhao TT, Zhu LL, Chen M, Zhou Q (corresponding author). Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food-drug pharmacokinetic interaction study in healthy Chinese volunteers.Patient Prefer Adherence. 2016 Oct 3;10:2031-2037.

Zhu LL, Zhou Q (corresponding author). The association between gastric acid inhibitors and delirium in geriatric inpatients: implications for clinical practice and research.Clin Interv Aging. 2016 Jun 16;11:797-9.  

Pan SD, Zhu LL, Chen M, Xia P, Zhou Q (corresponding author). Weight-based dosing in medication use: what should we know?Patient Prefer Adherence. 2016 Apr 12;10:549-60.  

Fang X, Zhu LL, Pan SD, Xia P, Chen M, Zhou Q (corresponding author). Safe medication management and use of narcotics in a Joint Commission International-accredited academic medical center hospital in the People's Republic of China. Ther Clin Risk Manag. 2016 Apr 6;12:535-44.  

Chen M, Zhou Q (corresponding author). Pharmaceutical interventions by collaboration between staff pharmacists and clinical pharmacists and implementation of Joint Commission International Accreditation Standards on medication use may optimize pharmacotherapy in geriatric patients. Clin Interv Aging. 2016 Nov 9;11:1575-1577. 

Chen M, Zhou Q (corresponding author). The use of oral suspension and rationally prescribing alternatives may be supplemental to the implementation of clopidogrel new algorithm comprising CYP2C19 pharmacogenetics and drug interactions.Ther Clin Risk Manag. 2016 Mar 2;12:351-2. 

Chen M, Qu BX, Chen XL, Hu HH, Jiang HD, Yu LS, Zhou Q (corresponding author), Zeng S. Construction of HEK293 cells stably expressing wild-type organic anion transporting polypeptide 1B1 (OATP1B1*1a) and variant OATP1B1*1b and OATP1B1*15. Pharmazie. 2016 Jun;71(6):337-9.

Zhao RY, He XW, Shan YM, Zhu LL, Zhou Q (corresponding author). A stewardship intervention program for safe medication management and use of antidiabetic drugs.Clin Interv Aging. 2015 Jul 23;10:1201-12.  

Zhu LL, Chen M, Zhou Q (corresponding author). Is Promethazine 6.25 mg Intravenous Dose Really Ideal to Treat Postoperative Nausea and Vomiting?J Perianesth Nurs. 2015 Aug;30(4):269-71.  

Jin JF, Zhu LL, Chen M, Xu HM, Wang HF, Feng XQ, Zhu XP, Zhou Q (corresponding author). The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection.Patient Prefer Adherence. 2015 Jul 2;9:923-42.

Wang ZY, Chen M, Zhu LL, Yu LS, Zeng S, Xiang MX, Zhou Q (corresponding author). Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy.Ther Clin Risk Manag. 2015 Mar 19;11:449-67. 

Zhu LL, Feng ZJ, Zhou Q (corresponding author). Personalized therapeutics of α₁-blockers in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.Clin Interv Aging. 2015 Mar 26;10:621-2. 

Wang HF, Jin JF, Feng XQ, Huang X, Zhu LL, Zhao XY, Zhou Q (corresponding author). Quality improvements in decreasing medication administration errors made by nursing staff in an academic medical center hospital: a trend analysis during the journey to Joint Commission International accreditation and in the post-accreditation era. Ther Clin Risk Manag. 2015 Mar 5;11:393-406.

Yao QQ, Qu BX, Zhou Q (corresponding author), Zeng S.[Establishment of reverse-phase high-performance liquid chromatography with chiral reagent derivatization for separation of fexofenadine enantiomers].Zhejiang Da Xue Xue Bao Yi Xue Ban. 2014 Mar;43(2):155-9. 

Shen Q, Zuo M, Ma L, Tian Y, Wang L, Jiang H, Zhou Q, Zhou H, Yu L, Zeng S. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.Chem Biol Interact. 2014 Oct 19;224C:89-99. 

Zhou Q, Yu LS, Zeng S.Stereoselectivity of chiral drug transport: a focus on enantiomer-transporter interaction.Drug Metab Rev. 2014 Aug;46(3):283-90. 

Huang M, Hu H, Ma L, Zhou Q, Yu L, Zeng S.Carbon-carbon double-bond reductases in nature.Drug Metab Rev. 2014 Aug;46(3):362-78. 

Xu HM, Cai HW, Dai HB, Yan XF, Zhou Q, Xu G, Huang ZQ, Mao W.Use of evidence-based pharmacotherapy for secondary prevention of coronary heart disease: a Chinese medicine hospital versus a general hospital. Chin J Integr Med. 2014 May;20(5):375-80. 

Yu L, Pu J, Zuo M, Zhang X, Cao Y, Chen S, Lou Y, Zhou Q, Hu H, Jiang H, Chen J, Zeng S.Hepatic glucuronidation of isoneochamaejasmin a from the traditional Chinese medicine Stellera chamaejasme L. Root.Drug Metab Dispos. 2014 Apr;42(4):735-43. 

Lan MJ, Zhu LL, Zhou Q (corresponding author). Medication administration errors made by nurses reflect the level of pharmacy administration and hospital information infrastructure.J Clin Nurs. 2014 Mar;23(5-6):894-5. 

Song P, Li W, Zhou Q (corresponding author). An outpatient antibacterial stewardship intervention during the journey to JCI accreditation.BMC Pharmacol Toxicol. 2014 Feb 26;15:8. 

Gao CH, Yu LS, Zeng S, Huang YW, Zhou Q (corresponding author). Personalized therapeutics for levofloxacin: a focus on pharmacokinetic concerns.Ther Clin Risk Manag. 2014 Mar 27;10:217-27. 

Chen Y, Zhu LL, Zhou Q (corresponding author). Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients.Ther Clin Risk Manag. 2014 Jun 13;10:437-48. 

Zhou YT, Yu LS, Zeng S, Huang YW, Xu HM, Zhou Q (corresponding author). Pharmacokinetic drug-drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management.Ther Clin Risk Manag. 2014;10:17-26. 

Zhu LL, Li W, Song P, Zhou Q (corresponding author). Injection device-related risk management toward safe administration of medications: experience in a university teaching hospital in The People's Republic of China.Ther Clin Risk Manag. 2014 Mar 17;10:165-72. 

Yu L, Shen Q, Zhou Q Jiang H, Bi H, Huang M, Zhou H, Zeng S.In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs.J Ethnopharmacol. 2013 Nov 25;150(2):485-91.

Zhu LL, Zhou Q (corresponding author). Therapeutic concerns when oral medications are administered nasogastrically. J Clin Pharm Ther. 2013 Aug;38(4):272-6. doi: 10.1111/jcpt.12041edit. Epub 2013 Apr 19. Review.

Yu L, Shi D, Ma L, Zhou Q, Zeng S. Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro.Biopharm Drug Dispos. 2013 Jul;34(5):278-87. 

Zhou Q, Ye Z, Ruan Z, Zeng S. Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe.J Ethnopharmacol. 2013 Apr 19;146(3):744-9.

Zhou Q, Chen QX, Ruan ZR, Yuan H, Xu HM, Zeng S.CYP2C9*3(1075A > C), ABCB1 and SLCO1B1 genetic polymorphisms and gender are determinants of inter-subject variability in pitavastatin pharmacokinetics.Pharmazie. 2013 Mar;68(3):187-94.

Zhou Q, Ruan ZR, Jiang B, Yuan H, Zeng S.Simvastatin pharmacokinetics in healthy Chinese subjects and its relations with CYP2C9, CYP3A5, ABCB1, ABCG2 and SLCO1B1 polymorphisms.Pharmazie. 2013 Feb;68(2):124-8.

Zhou Q, Ruan ZR, Yuan H, Xu DH, Zeng S.ABCB1 gene polymorphisms, ABCB1 haplotypes and ABCG2 c.421c > A are determinants of inter-subject variability in rosuvastatin pharmacokinetics. Pharmazie. 2013 Feb;68(2):129-34.

Chen QX, Hu HH, Zhou Q, Yu AM, Zeng S.An overview of ABC and SLC drug transporter gene regulation.Curr Drug Metab. 2013 Feb;14(2):253-64. 

Zhao XY, Xu HM, Zhou Q (corresponding author). Sampling times and genotyping concerns in bioequivalence evaluation of branded and generic formulations.Ther Clin Risk Manag. 2013;9:463-8.

Li W, Zeng S, Yu LS, Zhou Q (corresponding author). Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management. Ther Clin Risk Manag. 2013;9:259-71.

Li W, Zhu LL, Zhou Q (corresponding author). Safe medication use based on knowledge of information about contraindications concerning cross allergy and comprehensive clinical intervention.Ther Clin Risk Manag. 2013;9:65-72. 

Zhu XP, Zhu LL, Zhou Q (corresponding author). Prescribing practice and evaluation of appropriateness of enteral nutrition in a university teaching hospital.Ther Clin Risk Manag. 2013;9:37-43. 

Lan MJ, Zhou Q (corresponding author). Potential therapeutic hazards due to drug-drug interaction between topically and systemically coadministered medications.Ther Clin Risk Manag. 2013;9:313-7. 

Zhu LL, Zhou Q (corresponding author). Intervention for improving the appropriateness of physician orders for oral medications in geriatric VIP patients during the journey to JCI accreditation.Ther Clin Risk Manag. 2013;9:273-5. 

Xu HM, Chen Y, Xu J, Zhou Q (corresponding author). Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase.World J Gastroenterol. 2012 Nov 7;18(41):5972-8. 

Zhou Q, Ruan ZR, Yuan H, Zeng S.CYP2C9*3(1075A>C), MDR1 G2677T/A and MDR1 C3435T are determinants of inter-subject variability in fluvastatin pharmacokinetics in healthy Chinese volunteers.Arzneimittelforschung. 2012 Nov;62(11):519-24. 

Li L, Hu H, Xu S, Zhou Q, Zeng S.Roles of UDP-glucuronosyltransferases in phytochemical metabolism of herbal medicines and the associated herb-drug interactions.Curr Drug Metab. 2012 Jun 1;13(5):615-23.

Zhu LL, Song P, Zhou Q (corresponding author). A pragmatic approach to beta-lactam use in patients with penicillin allergy. Allergy Asthma Proc. 2013 Mar-Apr;34(2):193.

Yu-Wen H, Mei-Bian Z, Xiang X, Xiao-Hua X, Zhou Q, Le J. Socioeconomic Inequality in the Use of Rituximab Therapy Among Non-Hodgkin Lymphoma Patients in Chinese Public Hospitals. Asia Pac J Public Health. 2014;26 (2), 203-214.

Zhu LL, Xu LC, Wang HQ, Jin JF, Wang HF, Zhou Q (corresponding author). Appropriateness of administration of nasogastric medication and preliminary intervention. Ther Clin Risk Manag. 2012;8:393-401.

Zhu LL, Xu LC, Chen Y, Zhou Q (corresponding author), Zeng S. Poor awareness of preventing aspirin-induced gastrointestinal injury with combined protective medications. World J Gastroenterol. 2012 Jun 28;18(24):3167-72.

Huang YW, Jian L, Zhang MB, Zhou Q, Yan XF, Hua XD, Zhou Y, He JL. An investigation of oxidative DNA damage in pharmacy technicians exposed to antineoplastic drugs in two Chinese hospitals using the urinary 8-OHdG assay. Biomed Environ Sci. 2012 Feb;25(1):109-16.

Qu BX, Tian Y, Yu LS, Jiang HD, Zhou Q (corresponding author), Zeng S. [Chiral separation of fluvastatin enantiomers with in vitro cellular method]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Jan;40(1):12-6.

Zhou Q (corresponding author), Zhu LL, Yan XF, Pan WS, Zeng S. Drug utilization of clarithromycin for gastrointestinal disease treatment. World J Gastroenterol. 2008 Oct 21;14(39):6065-71.

Zhu LL, Zhou Q (corresponding author), Yan XF, Zeng S. Optimal time to take once-daily oral medications in clinical practice. Int J Clin Pract. 2008 Oct;62(10):1560-71.

Xu DH, Lou HG, Yuan H, Jiang B, Zhou Q, Zhang ZM, Ruan ZR (corresponding author). Quantitative determination of domperidone in human plasma by ultraperformance liquid chromatography with electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 2008 Apr;22(4):433-40.

Zhou Q (corresponding author), Yan XF, Pan WS, Zeng S. Is the required therapeutic effect always achieved by racemic switch of proton-pump inhibitors?World J Gastroenterol. 2008 Apr 28;14(16):2617-9.

Lou HG, Ruan ZR(corresponding author), Yuan H, Jiang B, Zhou Q. LC Determination and Bioequivalence Study of Pantoprazole in Human Plasma. Chromatographia, 2008.

Zhou Q (corresponding author), Yan XF, Zhang ZM, Pan WS, Zeng S. Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal disease treatment: drug metabolism and its related interactions. World J Gastroenterol. 2007 Nov 14;13(42):5618-28.

Zhou Q, Ruan Z, Yuan H, Jiang B, Xu D. RP-HPLC analysis of flucloxacillin in human plasma: validation and application to a bioequivalence study. Pharmazie. 2007 Feb;62(2):101-4.

Xu DH, Ruan ZR, Zhou Q, Yuan H, Jiang B. Quantitative determination of rosuvastatin in human plasma by liquid chromatography with electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(16):2369-75.

Zhou Q (corresponding author), Ruan ZR, Yuan H, Jiang B, Xu DH. Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations. World J Gastroenterol. 2006 May 7;12(17):2742-8.

Zhou Q (corresponding author), Ruan ZR, Drug utilization study of 2 statins in outpatients from a perspective of metabolic drug-drug interactions. Acta Pharmacol Sin, 2006, 27(Suppl 1): 206.

Jiang, Bo; Xu, Do-hang; Yuan, Hong; et al. Studies on correlation between dissolution in vitro and absorption in vivo of levofloxacin tablets.ACTA PHARMACOLOGICA SINICA, 2006, 27(Suppl 1):200-200. 

Xu, Dong-hang; Ruan, Zhou-rong; Zhou, Quan. Pharmacokinetics of rosuvastatin in Chinese healthy volunteers.ACTA PHARMACOLOGICA SINICA, 2006, 27(Suppl 1):223-223.

Ruan, Zou-Rong; Zhou, Quan; Yuan, Hong; et al. Pharmacokinetics and bioequivalence of fluvastatin tablet in Chinese healthy volunteers.ACTA PHARMACOLOGICA SINICA, 2006, 27(Suppl 1):224-224.

Yuan, Hong; Ruan, Zou-Rong; Zhou, Quan. Pharmacokinetics and bioequivalence of bismuth derived from two combined formulations of ranitidine and bismuth potassium citrate.ACTA PHARMACOLOGICA SINICA, 2006, 27(Suppl 1):225-225.

Zhou Q, Ruan ZR(corresponding author), Yuan H, Jiang B. Determination of penciclovir in human plasma using liquid chromatography with fluorescence detection: Application to a bioequivalence study. Chromatographia, 2006, 64(9-10):571-5.

Zhang ZM, Zheng XX, Jiang B, Zhou Q. Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia. Zhongguo Zhong Yao Za Zhi. 2004 Apr;29(4):371-3.

Zhou Q, Yao TW, Yu YN, Zeng S. Concentration dependent stereoselectivity of propafenone N-depropylation metabolism with human hepatic recombinant CYP1A2. Pharmazie. 2003 Sep;58(9):651-3.

Yan XF, Zhou Q, Yao TW, Zeng S, Yao HP, Yu YN. [Stereoselective determination of propranolol enantiomer in transgenic cell lines expressing human cytochrome P450]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Apr;32(2):116-20.

Zhou Q, Yao TW, Zeng S. Chiral reversed phase high-performance liquid chromatography for determining propranolol enantiomers in transgenic Chinese hamster CHL cell lines expressing human cytochrome P450. J Biochem Biophys Methods. 2002 Dec 31;54(1-3):369-76.

Zhou Q, Yao TW, Zeng S. Effects of stereochemical aspects on drug interaction in pharmacokinetics. Acta Pharmacol Sin. 2002 May;23(5):385-92.

Zhou Q, Yao TW, Zeng S. Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers. World J Gastroenterol. 2001 Dec;7(6):830-5.

Zhou Q, Yao TW, Yu YN, Zeng S. Stereoselective metabolism of propafenone by human liver CYP3A4 expressed in transgenic Chinese hamster CHL cells lines. Acta Pharmacol Sin. 2001 Oct;22(10):944-8.

Yao TW, Zhou Q, Zeng S. Stereoselective determination of propafenone enantiomers in transgenic Chinese hamster CHL cells expressing human cytochrome P450. Biomed Chromatogr. 2000 Nov;14(7):498-501.

Zhou Q, Yao TW, Zeng S. Chiral metabolism of propafenone in the rat hepatic microsomes treated with two inducers. Seventh Scientific Meeting in association with The Zhejiang Pharmacological Society, HONG KONG PHARMACOLOGY SOCIETY, OCT,2001,Hongkong.

Zhou Q, Yao TW, Zeng S. Study of the enantioselective metabolism of S(-) and R(+)-propranolol by using transgenic cells lines expressing human CYP2C18 and CYP2C9. 9th International Symposium of the Pacific Rim Association for Clinical Pharmacogenetics. Graduate Houses, The University of Hongkong, OCT, 2001.

Current Program

Stereoselectivity of chiral drugs transported by OATP1B1. Funding Source: National Natural Science Foundation of China. 

The interaction mechanism between SLC1B1 and CYP2C9. Funding Source: National Natural Science Foundation of China. 

important biomarkers related to personalized medicine and its new detection kit research and development key technology. Funding Source: Major Science and Technology Project-Major New Drug Innovation.

Find People

Search by Family Name

Find A Department

Search by Departments